Nonsteroidal Anti-Inflammatory Drugs Toxicity

Overview

4.7 out of 5 (15 Reviews)

Credits

1.00

Post Assessment Questions

4

Start Date

1 Sep 2023

Last Review Date

1 Sep 2023

Expiration Date

31 Aug 2026

Estimated Time To Finish

60 Minutes


 
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Activity Description

As a class, nonsteroidal anti-inflammatory drugs, commonly abbreviated as NSAIDs, are chemically varied, yet share similar therapeutic and adverse effects. All drugs within the class work to reduce inflammation, pain, and fever through inhibition of endoperoxide synthesis enzymes, known as cyclooxygenase (COX) enzymes. Both cyclooxygenase isozymes, COX-1 and COX-2, convert arachidonic acid into its endoperoxide metabolites, which include prostacyclin, prostaglandins, and thromboxane; these all have diverse biologic activity, ranging from inflammation, smooth muscle tone, and thrombosis. COX-1 is constitutively expressed and is considered the primary source of prostanoids needed for physiologic homeostases, such as protection of gastric epithelium. COX-2, on the other hand, is inducible, and its production of prostanoids is significantly upregulated during conditions of stress and inflammation. NSAIDs can also result in toxicity by the same pharmacology that makes them so effective therapeutically. This activity reviews the etiology, presentation, evaluation, and management of NSAID toxicity and reviews the role of the interprofessional team in evaluating, diagnosing, and managing the condition.

UAN: JA4008338-0000-23-4542-H01-P

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Describe the various pharmacologic mechanisms by which NSAIDs can cause toxicity.
  • Summarize the evaluation for a patient who may be showing signs of NSAID toxicity.
  • Review strategies to treat and manage NSAID toxicity, as well as steps to try to prevent it from happening.
  • Explain the importance of improving care coordination among the interprofessional team to improve outcomes for patients who either have or are potential candidates for developing NSAID toxicity.

Pharmacy Activity Type:
Disease/Drug Therapy Related


Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Pharmacists: StatPearls, LLC designates this activity for a maximum of 1.00 ACPE credit(s). (UAN: JA4008338-0000-23-4542-H01-P ). Pharmacists should only claim credit commensurate with the extent of their participation in the activity.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Maria B. on 3/7/2022

Dale R. on 3/9/2022

cyvada s. on 5/13/2022

Ashley F. on 6/27/2022

Kelly C. on 7/22/2022

Rachel D. on 9/26/2022

Jeff B. on 10/17/2022

Lindsey M. on 11/16/2022

Douglas M. on 12/13/2022

Sharon B. on 2/11/2023

Ashley F. on 3/22/2023

Mary M. on 5/10/2023

Elizabeth P. on 7/29/2023

Lily L. on 2/11/2024

Deborah P. on 1/22/2024

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