Cephalosporins

Overview

4.6 out of 5 (52 Reviews)

Credits

1.50

Post Assessment Questions

7

Start Date

1 Sep 2023

Last Review Date

17 Feb 2024

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes


 
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Activity Description

Cephalosporins are β-lactam antimicrobials used to manage various infections caused by both gram-positive and gram-negative bacteria. The 5 generations of cephalosporins demonstrate efficacy in treating skin and soft tissue infections, pneumonia, meningitis, and other infections. Cefiderocol is a novel siderophore cephalosporin that exhibits remarkable antibacterial activity. This drug has been approved by the US Food and Drug Administration (FDA) to treat complicated urinary tract infections and ventilator-associated pneumonia caused by highly resistant gram-negative bacteria, including Klebsiella pneumoniaProteus mirabilis, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii.

Cefiderocol emerges as a promising therapeutic option for challenging infections, with literature reviews suggesting its potential in combating strains resistant to carbapenems. Importantly, cefiderocol is the only recently approved β-lactam agent exhibiting in vitro activity against carbapenem-resistant A baumannii (CRAB) isolates. According to the Infectious Diseases Society of America guidelines, cefiderocol should be reserved for cases of CRAB infections that remain unresponsive to other antibiotics or when intolerance to alternative agents prohibits their use. This activity provides clinicians with comprehensive insights into indications, mechanisms of action, contraindications, monitoring protocols, potential adverse drug reactions, and clinical toxicology associated with cephalosporins. This activity also provides healthcare professionals with essential knowledge and necessary tools to make informed decisions, promptly identify adverse effects, and optimize patient outcomes through vigilant monitoring and effective cephalosporin utilization, thereby ensuring proficiency in antibiotic therapy.


UAN: JA4008338-0000-23-1026-H01-P

Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the spectrum of activity of cephalosporins against both gram-positive and gram-negative bacteria.

  • Screen patients for potential contraindications and drug interactions before initiating cephalosporin therapy.

  • Implement appropriate dosing regimens and administration routes for cephalosporins based on the type and severity of infection.

  • Coordinate with other healthcare team members to ensure timely and appropriate use of cephalosporins in multidisciplinary patient care plans.

Pharmacy Activity Type:
Disease/Drug Therapy Related


Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Pharmacists: StatPearls, LLC designates this activity for a maximum of 1.50 ACPE credit(s). (UAN: JA4008338-0000-23-1026-H01-P ). Pharmacists should only claim credit commensurate with the extent of their participation in the activity.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Mary S. on 7/27/2021

DIMITRIOS T. on 9/10/2021

Mirta A. on 10/19/2021

Laura B. on 12/28/2021

Brandy M. on 5/16/2022

Robin A. on 5/20/2022

Mica C. on 5/25/2022

Cara P. on 5/30/2022

Mark W. on 6/16/2022

Jennifer L. on 7/4/2022

Very educational.

Kelly A. on 8/24/2022

Christine G. on 10/28/2022

Dr.NIRMALA M. on 11/28/2022

Florence Y. on 1/14/2023

kevin n. on 1/20/2023

Austin S. on 1/20/2023

Skyler S. on 1/26/2023

Abbie J. on 2/25/2023

Raven H. on 3/17/2023

Haley K. on 3/31/2023

I wish there were tables to help me mentally stratify the cephalosporins.

john e. on 4/2/2023

Aaron M. on 4/18/2023

Rachel E. on 4/21/2023

Brianna B. on 4/24/2023

MELISSA B. on 5/10/2023

Cheyenne T. on 5/13/2023

Heather D. on 5/24/2023

Sheila C. on 6/17/2023

Matthew P. on 7/21/2023

Kara W. on 8/16/2023

Kathern R. on 9/21/2023

roxanna g. on 10/4/2023

Shelli H. on 10/21/2023

channa p. on 10/24/2023

Christine G. on 10/26/2023

Jack I. on 11/2/2023

Keaton A. on 11/14/2023

Matthew S. on 11/28/2023

John S. on 12/18/2023

makondo s. on 12/11/2023

Laura G. on 12/12/2023

Hawabu S. on 12/21/2023

Benjamin W. on 12/26/2023

Mandy H. on 12/27/2023

Stephen B. on 1/1/2024

Leila Z. on 2/25/2024

Kelly T. on 2/21/2024

John H. on 3/18/2024

Linda B. on 3/21/2024

Gary A. on 4/4/2024

Julie F. on 4/17/2024

Andrew R. on 4/17/2024

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