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Expiration Date

31 Dec 2023

Last Reviewed

9 May 2021

Estimated Time To Finish

60 Minutes

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Activity Description

The FDA recognized the combination of acetylsalicylic acid (250 mg), acetaminophen (250 mg), and caffeine (65 mg) as safe and effective in treating acute headaches, especially migraine, and was also considered effective by the American Headache Society (Level A). This combination is well-tolerated in episodic tension-type headaches and considered superior to acetaminophen; all components in this combination medication are considered safe during breastfeeding and can be taken orally for acute migraine attacks. This activity reviews the indications, contraindications, activity, adverse events, and other key elements of acetaminophen/aspirin/caffeine therapy in the clinical setting as it relates to the essential points needed by members of an interprofessional team managing the care of patients with migraine headaches and its related conditions and sequelae.

UAN: JA0007034-9999-21-038-H04-P
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Target Audience

This activity has been designed to meet the educational needs of pharmacists.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the mechanism of action and administration of aspirin/acetaminophen/caffeine.
  • Describe the potential adverse effects of aspirin/acetaminophen/caffeine.
  • Summarize the therapeutic place for aspirin/acetaminophen/caffeine in a headache pain control regimen.
  • Review the importance of coordinating and collaborating among various disciplines in an interprofessional health team to coordinate care and management to enhance outcomes for patients receiving aspirin/acetaminophen/caffeine therapy.

Pharmacy Activity Type:
General Pharmacy Topic

Author(s) / Contributors Disclosure of Conflicts of Interest

Hover over the contributor names to see details and disclosures of any financial relationships they have with commercial interests related to the content of this continuing education activity. All of the relevant financial relationships listed for these individuals have been mitigated.

COMMERCIAL SUPPORT: This activity has received NO commercial support.

Continuing Education Accreditation Information



CE credit provided by AKH Inc., Advancing Knowledge in Healthcare. This activity is jointly-provided by AKH Inc., Advancing Knowledge in Healthcare, and StatPearls Publishing, LLC.

In support of improving patient care, this activity has been planned and implemented by AKH Inc., Advancing Knowledge in Healthcare and StatPearls Publishing, LLC. AKH Inc., Advancing Knowledge in Healthcare is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

AKH Inc., Advancing Knowledge in Healthcare designates this continuing education activity for 1.00 contact hours for pharmacists.

FL Board of Pharmacy Tripartite, approval #20-608156.

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearls and AKH reserve the right to cancel any course due to unforeseen circumstances. StatPearls and AKH will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and AKH are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives, and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and AKH adhere to provider standards regarding commercial support of continuing education. It is the policy of StatPearls and AKH that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

Conflict of Interest Disclosure Policy:
It is the policy of AKH Inc. to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. The author must disclose to the participants any significant relationships with ineligible companies whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are mitigated by AKH prior to accreditation of the activity. AKH planners and reviewers have no relevant financial relationships to disclose.

Disclosure of Unlabeled Use:
This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional, and therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. AKH Inc. specifically disclaim responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through participant's misunderstanding of the content.


Media Usage Rights

The contributors and editors of StatPearls have attested that all associated media (images and video) have been legally cleared for use with this activity.  All copyrights are reserved.


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