Overview

4.4 out of 5 (11 Reviews)

Credits

1.00

Pharmacology Credits

0.5

Post Assessment Questions

5

Start Date

1 Sep 2023

Last Review Date

29 Mar 2024

Expiration Date

31 Aug 2026

Estimated Time To Finish

60 Minutes


 
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Activity Description

Uremia is a clinical condition associated with declining renal function and is characterized by fluid overload, electrolyte imbalances, metabolic abnormalities, and physiological changes. The term "uremia" literally means "urine in the blood," which develops most commonly in chronic and end-stage renal disease. However, less commonly, this condition can also manifest in acute kidney injury if kidney function deteriorates rapidly. Urea exhibits direct and indirect toxicity to various tissues, notably affecting the neurological system. Urea acts as a marker for uremic toxins in general, with over 100 substances identified as potential uremic toxins, which are present in varying concentrations in the blood. Urea and other uremic toxins, accumulated due to impaired renal clearance, are toxic to various tissues, especially the nervous system, leading to symptoms such as nausea, vomiting, fatigue, anorexia, muscle cramps, pruritus, and altered mentation. These manifestations significantly diminish a patient's quality of life and, if left untreated, can result in morbidity and mortality.

Due to the frequent occurrence of altered mental status in patients, early recognition by healthcare professionals is crucial for promptly initiating renal replacement therapy and potential renal transplant referral, leading to improved patient outcomes. Healthcare professionals must also vigilantly monitor for any signs of uremia to prevent associated complications. Timely referral to transplantation centers is associated with improved survival rates and reduced morbidity among uremia patients. This activity reviews the evaluation and management of uremia, emphasizing the collaborative role of interprofessional team members in delivering well-coordinated care to improve outcomes for affected patients.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify early signs and symptoms of uremia, including nausea, vomiting, fatigue, altered mentation, and electrolyte imbalances, to facilitate prompt diagnosis and treatment initiation.

  • Implement evidence-based interventions for managing uremia-related complications such as fluid overload, electrolyte imbalances, and metabolic abnormalities.

  • Assess renal function using appropriate laboratory tests and imaging modalities to monitor disease progression and treatment effectiveness.

  • Coordinate care across healthcare settings to ensure seamless transitions and continuity of care for patients undergoing renal replacement therapy and transplantation.

  • Outline the pharmacologic therapy as it applies to Uremia

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Nurse Practitioners: StatPearls designates this activity for 1.00 ANCC contact hour(s), which includes 0.5 hour(s) of pharmacology. NPs should only claim credit commensurate with the extent of their participation in the activity.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the FDA. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Trang T. on 2/18/2021

Travis V. on 12/5/2021

Aroona S. on 9/21/2022

Toni-Marie P. on 10/23/2022

mandeep s. on 11/12/2022

KKP S. on 5/13/2023

Brianna L. on 6/21/2023

Janet S. on 8/25/2023

Jonathan A. on 2/17/2024

Derrick R. on 3/7/2024

Azzam A. on 6/26/2024

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