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Release Date

5 Oct 2020

Expiration Date

30 Dec 2021

Last Reviewed

30 Dec 2020

Estimated Time To Finish

60 Minutes

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Activity Description

Immunodeficiency results from a failure or absence of elements of the immune system, including lymphocytes, phagocytes, and complement system. Immunodeficiencies can be primary or secondary. Primary immunodeficiency is subdivided into types that cause T-cell deficiency, B-cell deficiency, both T-cell and B-cell deficiency, complement deficiency, phagocyte deficiency, and immunoglobulin A deficiency. Primary immunodeficiencies leading to T-cell deficiency include DiGeorge syndrome, also known as congenital thymic aplasia, chronic mucocutaneous candidiasis, hyper-immunoglobulin M syndrome, and interleukin-12 receptor deficiency. Primary immunodeficiency leading to B-cell deficiency include X-linked agammaglobulinemia, also called Bruton agammaglobulinemia. Primary immunodeficiencies leading to both T-cell and B-cell deficiency include severe combined immunodeficiency disease, Wiskott-Aldrich syndrome, immunodeficiency with ataxia-telangiectasia, and Major Histocompatibility Complex deficiency. Primary immunodeficiencies leading to complement deficiency include hereditary angioedema, deficiency of C3, deficiency of membrane attack complex, and C2 or C4 deficiency secondary to autoimmunity. Primary immunodeficiencies leading to phagocyte deficiency include chronic granulomatous disease and leukocyte adhesion deficiency syndrome. Selective immunoglobulin A deficiency is also a primary immunodeficiency. Secondary causes of immunodeficiency include steroids, nutrient deficiency, obesity, acquired immune deficiency syndrome (AIDS), or other viral infections. This activity reviews the different immunological disorders, their evaluation, and management, and highlights the role of the interprofessional team in caring for affected individuals.

Target Audience

This activity has been designed to meet the educational needs of nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Outline the immunodeficiency disorders.
  • Describe the presentation of a patient with an immunodeficiency disorder.
  • Review the treatment options for immunodeficiency disorders.
  • Explain the importance of improving care coordination among interprofessional team members to improve outcomes for patients with immunodeficiency disorders.
  • Outline the pharmacologic therapy as it applies to Immunodeficiency

Author(s) / Contributors Disclosure of Conflicts of Interest

Each author, editor, faculty and planning committee member have completed a disclosure form indicating that neither they nor their spouse/partner has a financial interest/arrangement or affiliation that could be perceived as a real or apparent conflict of interest related to the content of this activity.

COMMERCIAL SUPPORT: This activity has received NO commercial support.


Hover over the contributor names to see details and disclosures of any financial relationships or relationships they or their spouse/life partner have with commercial interests related to the content of this continuing education activity.

Continuing Education Accreditation Information


This activity has been planned and implemented in accordance with the Accreditation Standards of the American Association of Nurse Practitioners (AANP) through the joint providership of AKH Inc., Advancing Knowledge in Healthcare and StatPearls Publishing, LLC.  AKH Inc., Advancing Knowledge in Healthcare is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 030803.  This activity is approved for 1.00 contact hour(s) (which includes 0.1 hour(s) of pharmacology).

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearls and AKH reserve the right to cancel any course due to unforeseen circumstances. StatPearls and AKH will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Equal Opportunity

  • StatPearls and AKH are Equal Opportunity / Affirmative Action / Equal Access Institutions. 

Medium or Media Used:

  • Computer Requirements:  Internet Access
  • E-mail Address

Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the required accreditation information:  Target audience, learning objectives, and disclosure information.
  3. Complete the entire self-study activity.
  4. Complete the post-test assessments.
  5. Successfully pass the post-test with a minimum score of 100%.
  6. Complete the evaluation form.
  7. Obtain a certificate.

StatPearls and AKH adhere to provider standards regarding commercial support of continuing education. It is the policy of StatPearls and AKH that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved and also that authors and editors will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made prior to starting the activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.

  • If you have concerns regarding the CE system, please contact, or call 727-289-9796.
  • If you have concerns regarding CE, please contact or call AKH 877-AKH-CME4.


Media Usage Rights

The contributors and editors of StatPearls have attested that all associated media (images and video) have been legally cleared for use with this activity.  All copyrights are reserved.

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