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Expiration Date

31 Dec 2025

Last Reviewed

1 Jan 2023

Estimated Time To Finish

180 Minutes

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Activity Description

Syphilis is a systemic, bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” The origin of syphilis has been controversial and under great debate, and many theories have been postulated regarding this. Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. The infection progresses through four stages and can affect many organ systems. Luckily, the causative organism is still sensitive to penicillin. This activity reviews the cause, pathophysiology, and presentation of syphilis and highlights the role of the interprofessional team in its management.

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Target Audience

This activity has been designed to meet the educational needs of individuals in nursing.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Review the stages of syphilis.
  • Describe the process of diagnosing syphilis.
  • Summarize the treatment of syphilis.
  • Outline the importance of improving care coordination among interprofessional team members to improve outcomes for patients affected by syphilis.


StatPearls requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. 

COMMERCIAL SUPPORT: This activity has received NO commercial support.


Continuing Education Accreditation Information

Credit provided by Continuing Education, Inc, and StatPearls, LLC.

In support of improving patient care, this activity has been jointly planned and implemented by Continuing Education, Inc./University at Sea® and StatPearls, LLC. Continuing Education, Inc, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

This activity is designated for 3.00 ANCC contact hours.


Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content in the activity.
  4. Choose the best answer to each activity test question. To receive credit, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment.
  6. Obtain a certificate.

For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.


Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearlsand and Continuing Education, Inc, reserve the right to cancel any course due to unforeseen circumstances. StatPearls and Continuing Education, Inc, will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Medium or Media Used:

  • Computer Requirements: Internet Access
  • E-mail Address

Equal Opportunity

  • StatPearls and Continuing Education are Equal Opportunity/Affirmative Action/Equal Access Institutions. 


Media Usage Rights

The contributors and editors of StatPearls have attested that all associated media (images and video) have been legally cleared for use with this activity.  All copyrights are reserved.

  • Name: 'syphilis.jpg' Attribution: Contributed by DermNetNZ
  • Name: 'Secondary_Syphilis_on_palms_CDC_6809_lores.rsh.jpg' Attribution: Contributed by Wikimedia Commons, Robert Sumpter (CDC) (Public Domain)
  • Name: 'PHIL_2346_lores.jpg' Attribution: Contributed by Susan Lindsley, The Centers for Disease Control and Prevention (CDC)
  • Name: 'Screen Shot 2019-01-21 at 10.10.06 AM.png' Attribution: Contributed by The Centers for Disease Control and Prevention (CDC)
  • Name: 'primary syphilis chancre SV.JPG' Attribution: Contributed by Dr. Shyam Verma, MBBS, DVD, FRCP, FAAD, Vadodara, India


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The information was well explained.

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