Ziprasidone

Overview

4.6 out of 5 (40 Reviews)

Credits

1.00

Post Assessment Questions

6

Start Date

1 Sep 2023

Last Review Date

26 Feb 2024

Expiration Date

31 Aug 2026

Estimated Time To Finish

60 Minutes


 
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Activity Description

Ziprasidone, an atypical antipsychotic, is approved by the US Food and Drug Administration (FDA) for the treatment of schizophrenia, bipolar mania, and acute agitation in individuals with schizophrenia. In schizophrenia treatment, the drug exerts therapeutic antagonism on dopamine (D2) and serotonin (5HT2) receptors. However, due to its antagonism with H1 receptors, ziprasidone may induce somnolence. Studies have demonstrated that ziprasidone was markedly superior to placebo in both the rate and duration of relapse when treating schizophrenia. The research confirmed the efficacy of ziprasidone in bipolar disorder, also highlighting improvement on the manic syndrome subscale. This scale assesses symptoms of mania, including mood, insomnia, excessive energy and activity, as well as overall behavior and ideation.

The medication is additionally used off-label for treatment-resistant depression, delusional parasitosis, hypomania associated with bipolar II disorder, managing delirium in the intensive care unit, as well as addressing agitation or aggression due to substance intoxication or other natural causes. This activity outlines the indications, mechanism of action, administration methods, significant adverse effects, contraindications, monitoring, and toxicity of ziprasidone, thereby guiding clinicians to effectively direct patient therapy, particularly in cases where ziprasidone can enhance patient care.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify indications for ziprasidone therapy, including schizophrenia, bipolar disorder, and acute agitation.

  • Screen patients for potential contraindications and risk factors before initiating ziprasidone treatment.

  • Implement appropriate dosing strategies based on patient-specific factors, such as age, weight, and renal function.

  • Collaborate with interdisciplinary healthcare team members to ensure comprehensive patient care and monitoring.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Nurses: StatPearls designates this activity for 1.00 ANCC contact hour(s). Nurses should only claim credit commensurate with the extent of their participation in the activity.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Harry A. on 10/17/2021

ANWAR S. on 11/17/2021

Michael P. on 12/27/2021

Gwendolyn R. on 1/26/2022

MIA G. on 2/10/2022

YOUN JU L. on 3/16/2022

Christine D. on 5/15/2022

Gordon C. on 6/21/2022

Brittany T. on 8/1/2022

Peter M. on 8/28/2022

Alex N. on 8/30/2022

Tracy L. on 9/23/2022

Sarah P. on 11/14/2022

Kecia T. on 12/26/2022

Nancy G. on 1/4/2023

Latoya R. on 1/24/2023

Lisa B. on 1/29/2023

Dakota P. on 2/15/2023

Jorge M. on 2/27/2023

Kristi W. on 5/13/2023

Ejaz J. on 5/21/2023

Cheryl M. on 6/1/2023

Peter M. on 6/6/2023

Sushma B. on 8/5/2023

John P. on 8/18/2023

Brittany n. on 8/13/2023

Danielle K. on 12/20/2023

Brian C. on 12/27/2023

John P. on 1/6/2024

Kasie C. on 1/25/2024

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Jibril Y. on 2/24/2024

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