Overview

4.6 out of 5 (16 Reviews)

Credits

1.00

Post Assessment Questions

6

Start Date

1 Sep 2023

Last Review Date

14 Feb 2024

Expiration Date

31 Aug 2026

Estimated Time To Finish

60 Minutes


 
Need Help?  If you have a system or content concerns, please contact support@statpearls.com

Activity Description

Orlistat (tetrahydrolipstatin) is an anti-obesity medication approved by the US Food and Drug Administration (FDA). This medication is a saturated derivative derived from the endogenous lipstatin found in Streptomyces toxytricini. Orlistat is used to manage obesity by reversibly inhibiting gastric and pancreatic lipases within the gut. These lipases play a crucial role in the digestion of dietary fat by breaking down triglycerides into absorbable free fatty acids and monoglycerides. Orlistat binds covalently to the serine residues of the active sites of these lipases, rendering them inactive. This inactivation of lipase prevents the hydrolysis of triglycerides, thereby impeding the absorption of free fatty acids.

The maximum benefit of orlistat is achieved when it is combined with a balanced diet and regular exercise. The off-label use of orlistat includes the treatment of obesity in patients with heart failure, as per the American Heart Association. This activity reviews orlistat's mechanism of action, adverse events, administration, pharmacodynamics, pharmacokinetics, monitoring strategies, clinical toxicology, and relevant drug interactions related to the care of patients with obesity. This activity also highlights the crucial role of participating clinicians and emphasizes the significance of incorporating dietitians and pharmacists in prescription guidelines to enhance patient outcomes.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify appropriate candidates for orlistat therapy based on obesity severity, comorbidities, and contraindications.

  • Implement comprehensive monitoring strategies to evaluate orlistat's efficacy and assess adverse events during treatment.

  • Apply evidence-based guidelines to optimize orlistat therapy in combination with diet and exercise for maximum efficacy.

  • Collaborate with dietitians and pharmacists to develop individualized treatment plans and monitor patient progress to ensure ongoing support and adjustments to orlistat therapy as needed.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Nurses: StatPearls designates this activity for 1.00 ANCC contact hour(s). Nurses should only claim credit commensurate with the extent of their participation in the activity.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

marion d. on 2/23/2021

Rana M. on 2/26/2021

Michelle s. on 9/21/2021

Kimberly T. on 7/26/2022

Jamie J. on 2/26/2023

Harlan H. on 3/30/2023

Lisa B. on 4/3/2023

srinivasu k. on 6/11/2023

none

Mary R. on 7/23/2023

Robert T. on 8/24/2023

amy i. on 9/26/2023

Julie C. on 12/7/2023

Barbara C. on 1/30/2024

Jennifer H. on 2/11/2024

Kristi S. on 2/27/2024

Tiffany S. on 3/13/2024

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