Bone ossification, or osteogenesis, is the process of bone formation. This process begins between the sixth and seventh weeks of embryonic development and continues until about age twenty-five; although this varies slightly based on the individual. There are two types of bone ossification, intramembranous and endochondral. Each of these processes begins with a mesenchymal tissue precursor, but how it transforms into bone differs. Intramembranous ossification directly converts the mesenchymal tissue to bone and forms the flat bones of the skull, clavicle, and most of the cranial bones. Endochondral ossification begins with mesenchymal tissue transforming into a cartilage intermediate, which is later replaced by bone and forms the remainder of the axial skeleton and the long bones.
Salter-Harris fractures are fractures of the epiphyseal plate. These types of fractures have the potential to impair bone ossification depending on the location. Injury to the epiphyseal plate can result in decreased longitudinal growth, angular deformity, and altered joint mechanics.
Age estimation of the fetus is one of the primary objectives of the fetal autopsy.
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