Perimortem Cesarean Delivery

Article Author:
Ajit Alexander
Article Editor:
Susan Lobrano
Updated:
2/2/2019 12:03:29 AM
PubMed Link:
Perimortem Cesarean Delivery

Introduction

Delivery by Cesarean section dates to 800 BCE. Unfortunately, at the time, the procedure was only done on a deceased or dying pregnant patient. It was not until the late 19th and 20th centuries when the first cases of perimortem cesarean section-use for salvage of the fetus were described. During the 1980s, additional case reports described its use to improve the survival of the mother.

One of the most daunting scenarios to face during an emergency department (ED)/critical care shift is the sudden, adverse change in a pregnant patient's health. These occurrences are rare and are the result of pre-existing conditions with severe, unforeseen medical, obstetric complications. This is also the scenario when patients arrive in extremis from a traumatic insult. An astute physician must be prepared and ready to do what is appropriate to save the life of the mother and the fetus. This includes considering a perimortem Cesarean section (C-section) (PMCS). A perimortem C-section is defined as a C-section performed during imminent cardiac arrest or active cardiac arrest, with the ultimate goal to successfully resuscitate the mother and improve fetal survivability. It is also referred to as resuscitative hysterotomy

PMCS is now a rarely performed procedure as the pregnancy-related death rates are overall low. Although the incidence of PMCS has not been well documented, the incidence of cardiac arrests during pregnancy is 1/30,000. Prior to 1986, only 188 cases were reported. From 1986 to 2004, only 38 additional cases were reported in the United States. The majority of them were performed in the ED setting, and occasional reports document pre-hospital scenarios. Despite the scarcity of data, with expedited deliveries, fetal survivability can be as high as 70%, with successful maternal resuscitations. Of the 38 case reports mentioned earlier, additional data revealed that the most common causes of maternal arrest requiring to PMCS were trauma, pulmonary embolism, cardiac causes, sepsis, and eclampsia. In the Netherlands, a retrospective questionnaire and medical survey review over 15 years (1993 through 2008), revealed 55 pregnant patients who suffered cardiac arrest, and only 12 (22%) of them had a PMCS.[1] Other risk factors which have been documented from prior case series include obesity and advanced maternal age older than 35.

Anatomy

Abdominal Wall

Incision of the abdominal wall is one the most frequently performed surgical procedures. Prior to performing a rush PMCS, it is ideal to have a basic understanding of the layers involved. There are 9 layers of the abdominal wall which include the skin, subcutaneous tissue, superficial fascia, external oblique muscle, internal oblique muscle, transversus abdominis muscle, transversalis fascia, preperitoneal adipose and areolar tissue, and peritoneum. The blood supply for the abdominal wall is composed of superficial and deep arteries. The superficial blood supply is located in the subcutaneous tissue and supplies blood to everything above the external oblique aponeurosis and anterior rectus sheath. It consists of the superficial inferior epigastric, superficial external pudendal, and superficial circumflex artery. The deep blood vessels are located in the musculofascial layers and supply blood to the muscles and fascia below the external oblique aponeurosis. A midline incision is an ideal approach in PMCS because it takes advantage that only the terminal branches of the blood vessels and nerves are in the linea alba. This reduces the risk for major bleeds and nerve damage from the procedure and provides the most significant exposure to the abdominal organs.

The Uterus  

Understanding uterine anatomy is imperative for ensuring optimal exposure, maximizing hemostasis, and avoiding injury to critical abdominal structures such as viscera, blood vessels, and nerves. The uterus can be divided into 2 portions, the uterine corpus, and the uterine cervix. The uterine corpus, which is also known as the body, has an inverted triangular shape. The superior portion of the body is called the fundus. An inferior portion which joins the cervix is known as the isthmus. The body is made up of 3 layers which are the serosa (outer layer), myometrium (middle layer), and endometrium (inner layer). The uterus is supported by the uterosacral and cardinal ligament complex, round ligament, broad ligament, and the endo-pelvic fascia. The blood supply for the uterus mainly comes from the uterine artery. The uterine artery originates from the anterior division of the internal iliac arteries in the retroperitoneum. The practioner should be aware of the importance the course of the uterine artery. The uterine artery courses through the cardinal ligament and passes over the ureter (located 1.5-cm lateral to the uterus). It reaches the uterus at the level of the internal cervical os. The uterine arteries give off branches, which tortuously course along the lateral aspect of the uterus, running superiorly to the corpus, and inferiorly to the cervix. The corpus also receives collateral flow from anastomoses of the ovarian arteries.

Physiology 

There are physiologic changes that occur during late pregnancy. During the third trimester of pregnancy, there is an increase in cardiac output and circulating blood volume by 30% to 40%. This is important because maternal signs and symptoms of shock may not manifest until the mother has lost over 40% of her blood volume. Also, an enlarged uterus can elevate the diaphragm about 4 cm which, in turn, can cause a 20% decrease in functional residual capacity. Finally, the gravid uterus can cause compression of inferior vena cave (IVC) leading to hypotension.

Indications

Traditional teaching expresses that resuscitative hysterotomy is performed in mothers carrying a fetus of a gestational age of 24 weeks or older, who are in peri-arrest, or have actively arrested. At 24 weeks, the fetus is considered viable. There is also a 20% to 30% fetal survivability at 24 weeks onward if PMCS is performed in a scenario where appropriate neonatal critical care facilities exist. Newer theories argue the 24-week rule, as the primary goal of resuscitative hysterotomy is the resuscitation of the mother. Also, when a patient arrives in extremis, the gestational age may not be known, and the use of ultrasound is not practical. A quick evaluation of fundal height can aid in estimating gestational age. If the uterus fundus can be seen at the umbilicus, the gestational age can be considered to be about 20 weeks. The uterine fundus grows about 1 cm every week after that.

Another critical factor in determining the need to perform PMCS is the time from arrest. Resuscitative hysterotomy should be performed as soon as the patient arrests, with goal delivery time within the first 4 minutes of arrest. Four minutes is used because this corresponds to the time after which there will be a precipitous decline in neurologic recovery for the infant from anoxic injury. It is important to re-iterate that PMCS can offer resuscitative benefit to the mother despite fetal survivability or neurological outcome. The 2010 American Heart Association (AHA) guidelines for CPR and Emergency Cardiovascular Care recommend considering starting resuscitative hysterotomy after 2 cycles of CPR.[2][3]

Contraindications

Contraindications to PMCS

  • If the patient achieves ROSC within a brief period of resuscitation
  • Gestational age less than 24 weeks (relative contraindication)

Equipment

  1. Definitive airway kit
  2. Oxygen
  3. Two large bore IVs
  4. End-tidal CO2 monitor 
  5. Cesarean delivery kit, trauma laparotomy kit
  6. No. 10 Scalpel
  7. Hemostats
  8. Large scissors
  9. Gauze sponges
  10. Large retractors/bladder retractors
  11. Infant warmer 
  12. Bulb suction 
  13. Pediatric airway kit

It is important to remember that the procedure also includes active simultaneous resuscitation. The first 4 types of equipment ensure adequate and effective resuscitation and the next 6 are required for the surgical aspects of the procedure. The physician and personnel taking part in the resuscitative portion of the procedure must be different than the physician performing the surgical aspect. In the setting of successful resuscitation, an operating room (OR) room must be available for subsequent closure. Finally, the last 3 pieces of equipment will be needed for the infant resuscitation.

Personnel

An interprofessional approach should be employed. As is in the setting for a trauma activation, a team of emergency medicine physicians, trauma surgeons, obstetrics and gynecology physicians, anesthesiologists, pediatric neonatologist, and emergency (ER)/intensive care unit (ICU), obstetrics (OB), and neonatal intensive care unit (NICU) trained nursing staff should be present for these scenarios.

Preparation

If there is a concern for a peri-arrest scenario or if the patient is actively arresting, an interprofessional team must be consulted, including neonatology, and obstetrics and trauma surgery, if needed, and involved early. The physician performing the procedure should try to wear sterile attire if and when possible. The mother should remain the supine position. A left lateral tilt can be employed but is not always necessary. Iodine solutions can be used to sterilize the skin before incision.

As most of the patients will require PMCS secondary to a traumatic cause, it is essential to discuss basic management principles in the setting of trauma. When faced with a pregnant trauma patient, it is crucial to understand that the focus of care should initially be on resuscitating the mother. Special considerations should also be given to the primary survey, airway, breathing, and circulation (ABCs). First, when managing the airway, it is important to realize that during the third trimester, there is a physiologic narrowing of the airway. Therefore, it is preferential to use an endotracheal tube that is 1 size smaller. Also, rapid sequence intubation is the recommended method of intubation given an increased risk for aspiration.

Regarding breathing, pregnant patients have a higher disposition of rapid decline in their PaO2 during apneic episodes. It is important to place all pregnant patients on supplemental oxygen (O2), regardless of their peripheral capillary oxygen saturation (SpO2). Given the sizeable circulating blood volume, hypovolemia must be considered in pregnant patients before the presentation of clinical signs and symptoms of hypovolemia, and shock. Aggressive fluid resuscitation should be initiated despite normal blood pressure readings.

In addition, while chest compressions are being performed, maneuvers must be employed to displace the gravid uterus from the inferior vena cava. Older teachings have recommended placing a board behind the back, with a 30-degree tilt to the left; however, this may make CPR more difficult and less effective. Newer models propose that the uterus be manually displaced with 2 hands to the left of the patient while CPR is actively being performed.

Technique

The physician performing perimortem cesarean section should ideally be one with the most surgical experience in the room. During normal Cesarean deliveries, the most common types of incisions utilized include the Joel-Cohen incision, Pfannenstiel incision, and midline vertical incision. However, in the setting of a perimortem C-section, a midline vertical incision is the preferred initial approach. The initial incision should begin from the level of the uterine fundus to the pubic symphysis. Other authors have quoted a more optimal approach with an incision from the xiphoid to the pubis. Ideally, a No. 10 blade scalpel should be used for the incision. One should cut through the subcutaneous tissues to get to the peritoneal wall, and blunt dissection can be used to achieve this method as well. Once the peritoneal wall is reached, an incision can be made inferiorly with a scalpel, or scissors (ideally). Subsequently, the peritoneum can be cut vertically with scissors. Once the uterus is delivered, a midline vertical incision should be made on the lower portion of the uterine corpus to avoid the placenta while avoiding the bowel and the bladder. Once the uterine cavity is initially entered, the index and middle fingers should be used to separate the uterine wall away from the fetus, and then the incision can be extended with scissors. The incision should be extended upward until the baby is exposed. Once exposed, the cord should be clamped, and cut. Once delivered the infant should be promptly resuscitated. The open uterus and the abdomen should be packed to prevent further bleeding. Further closure of the incision depends on the maternal response resuscitative efforts. ACLS/ATLS should be continued on mother until ROSC is achieved, and if achieved further closure should be continued in the OR. Also, if maternal survivability is considered likely, then the patient should receive antibiotic prophylaxis with any broad-spectrum penicillin or cephalosporin in a single dose.[4][5]

Complications

Bladder Injury

  • This can be avoided by using retractors to displace the bladder inferiorly.
  • If distended, the bladder can be decompressed with needle aspiration or with the use of a Foley catheter, prior to initiation of the procedure.[6]

Injury to the Fetus

  • This can be avoided by creating a lower midline uterine incision to avoid placental injury.
  • Use scissors to extend the incision superiorly, once the uterine cavity is exposed inferiorly, instead of a scalpel.

Arterial Injury

  • A midline abdominal incision will avoid major arterial bleeding.
  • Avoid transverse of lateral uterine incisions as the uterine blood vessels run laterally along the uterine border.

Clinical Significance

The goal of resuscitative hysterotomy should be primarily aimed at saving the life of the mother. PMCS improves maternal survivability by decreasing compression of the IVC by the gravid uterus which improves venous return. PMCS will also improve diaphragmatic displacement, which in turn improves respiratory dynamics.[7][8][9]

Enhancing Healthcare Team Outcomes

In the setting of a peri-arresting or arrested pregnant patient, the highest likelihood for survival for the mother and the infant is when an interprofessional approach is employed early in the course of the arrest. As is in the setting for a trauma activation, a team of emergency medicine physicians, trauma surgeons, obstetrics and gynecology physicians, anesthesiologists, pediatric neonatologist, and ER- or ICU-trained nursing staff should be present for these scenarios. Hospital policies should be set in place for a peri-arrest or arresting pregnant patient. This allows for easy and early activation of the groups mentioned above. As mentioned earlier, the procedure should be performed by the physician with the most surgical experience in the room, to reduce complications. Areas, where this situation can occur (i.e., ED, ICU, labor and delivery), should also have easy access to all equipment required to perform the procedure. Per AHA 2010 guidelines, "Team planning should be done in collaboration with the obstetric, neonatal, emergency, anesthesiology, intensive care, and cardiac arrest services (Class I, LOE C)."[2]


References

[1] Drukker L,Hants Y,Sharon E,Sela HY,Grisaru-Granovsky S, Perimortem cesarean section for maternal and fetal salvage: concise review and protocol. Acta obstetricia et gynecologica Scandinavica. 2014 Oct     [PubMed PMID: 25060654]
[2] Vanden Hoek TL,Morrison LJ,Shuster M,Donnino M,Sinz E,Lavonas EJ,Jeejeebhoy FM,Gabrielli A, Part 12: cardiac arrest in special situations: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2010 Nov 2     [PubMed PMID: 20956228]
[3] Krywko DM,Presley B, Cesarean, Perimortem null. 2018 Jan     [PubMed PMID: 29083739]
[4] Stokes N,Kikucki J, Management of Cardiac Arrest in the Pregnant Patient. Current treatment options in cardiovascular medicine. 2018 Jun 19     [PubMed PMID: 29922883]
[5] Zelop CM,Einav S,Mhyre JM,Martin S, Cardiac arrest during pregnancy: ongoing clinical conundrum. American journal of obstetrics and gynecology. 2018 Jul     [PubMed PMID: 29305251]
[6] Kikuchi J,Deering S, Cardiac arrest in pregnancy. Seminars in perinatology. 2018 Feb     [PubMed PMID: 29246735]
[7] Baraka A, PERIMORTEM CESAREAN DELIVERY. Middle East journal of anaesthesiology. 2016 Feb;     [PubMed PMID: 27382806]
[8] Benson MD,Padovano A,Bourjeily G,Zhou Y, Maternal collapse: Challenging the four-minute rule. EBioMedicine. 2016 Apr;     [PubMed PMID: 27211568]
[9] Eldridge AJ,Ford R, Perimortem caesarean deliveries. International journal of obstetric anesthesia. 2016 Aug;     [PubMed PMID: 27103543]