Dyspnea on Exertion (DOE)

Article Author:
Sandeep Sharma
Article Author:
Muhammad Hashmi
Article Editor:
Madhu Badireddy
Updated:
3/29/2020 9:42:31 PM
PubMed Link:
Dyspnea on Exertion (DOE)

Introduction

Dyspnea, also known as shortness of breath, is a patient's perceived difficulty to breathe. Sensations and intensity can vary and are subjective. It is a prevalent symptom impacting millions of people. It may be the primary manifestation of respiratory, cardiac, neuromuscular, psychogenic, or systemic illnesses, or a combination of these. Dyspnea on exertion is a similar sensation. However, this shortness of breath is present with exercise and improves with rest. Exercise is defined here as any physical exertion, which increases metabolic oxygen demand above the body's ability to compensate. Oxygen is vital to the human body as it is used for oxidative phosphorylation, and it is the last acceptor of an electron in the electron transport chain. The sensation of dyspnea mostly comes when our body is lacking oxygen delivery.[1]

Oxygen Delivery:  Hb x 1.39 x SaO2 x Cardiac Output + 0.003 x Pao2

  • Hb is the concentration of hemoglobin in grams per liter
  • 1.39- oxygen binding capacity of hemoglobin per gram
  • SaO2 is hemoglobin oxygen saturation expressed as a fraction (like- 98% will be 0.98)
  • Cardiac output is described as the amount of blood pumped by the heart in liter per minute
  • 0.003 x pao2 is the amount of dissolved oxygen in the blood in milliliters

If a body has low Hb, hemoglobinopathies, some toxicities affecting Hb (like carbon monoxide toxicity), low cardiac output (congestive heart failure [CHF], myocardial infarction [MI], arrhythmia) a person will feel dyspneic.[2]

Etiology

Dyspnea on exertion is a symptom of various diseases rather than a disease itself. As such, its etiology can be designated as arising from two primary organ systems: the respiratory system and the cardiac system. Other systemic illnesses may by culprit as well as a combination of different etiologies.

Respiratory causes may include asthma, acute exacerbation of chronic obstructive pulmonary disorder (COPD), pneumonia, pulmonary embolism, lung malignancy, pneumothorax, or aspiration.[1]

Cardiovascular causes may include congestive heart failure, pulmonary edema, acute coronary syndrome, pericardial tamponade, valvular heart defect, pulmonary hypertension, cardiac arrhythmia, or intracardiac shunting.

Other systemic illnesses, such as anemia, acute renal failure, metabolic acidosis, thyrotoxicosis, cirrhosis of the liver, anaphylaxis, sepsis, angioedema, and epiglottitis, may also cause dyspnea on exertion.

Epidemiology

The epidemiology of dyspnea on exertion is highly variable depending on etiology.[1]

Pathophysiology

Dyspnea on exertion is the sensation of running out of the air and of not being able to breathe fast or deeply enough during physical activity. It results from multiple signal interactions with receptors in the central nervous system (CNS), peripheral chemoreceptors, and mechanoreceptors in the respiratory tract and chest wall.

The respiratory center is comprised of 3 neuron groupings in the brain: the dorsal and ventral medullary groups and the pontine grouping. The pontine grouping further classifies into the pneumotaxic and apneustic centers. Inhalation is managed by the dorsal group, and the ventral medulla accounts for exhalation. The pontine groupings play their part in modulating the intensity and frequency of the medullary signals where the pneumotaxic groups limit inhalation, and the apneustic centers prolong and encourage inhalation. Each of these groups communicates with one another to unify the efforts as the pace making potential of respiration.

Sensory information to the respiratory center regarding the volume of the lung space is provided by mechanoreceptors located in the airways, trachea, lung, and pulmonary vessels. There are two primary types of thoracic sensors: slow adapting stretch spindles and rapid adapting irritant receptors. Slow-acting spindle sensors convey only volume information.

However, the rapid-acting receptors respond to both the volume of the lungs and chemical triggers, such as foreign agents that may be harmful. Both kinds of mechanoreceptors signal through cranial nerve X to the brain to escalate the rate of breathing, the volume of breaths, or to stimulate coughing patterns of breathing because of irritants present in the airway.

Peripheral chemoreceptors comprise of the carotid and aortic bodies. Both receptors function to monitor the partial pressure of oxygen in the arterial blood. However, hypercapnia and acidosis enhance the sensitivity of these sensors and play a partial role in the functioning of receptors. Once stimulated by hypoxia, carotid and aortic bodies send a signal via cranial nerve IX (the glossopharyngeal nerve) to the nucleus tractus solitarius in the brain, which then, stimulates excitatory neurons to increase the rate of ventilation. It has been postulated that the carotid bodies comprise 15% of the total driving force of respiration.[3]

Central chemoreceptors manage the majority of control over the respiratory drive. They function by sensing pH changes in the CNS. Prime locations within the brain include the ventral surface of the medulla and the retrotrapezoid nucleus. pH changes within the brain, and surrounding cerebrospinal fluid is derived primarily from increases or decreases in carbon dioxide levels. Carbon dioxide is a lipid-soluble molecule that freely diffuses across the blood-brain barrier. This characteristic proves to be useful in that rapid changes in pH within the cerebrospinal fluid are possible. Chemoreceptors responsive to pH change are located on the ventral surface of the medulla. As these areas become more acidic, sensory input is generated to stimulate hyperventilation, and carbon dioxide within the body is reduced through the increased ventilation. When pH rises to more alkalotic levels, hypoventilation occurs, and carbon dioxide levels decrease secondary to decreased ventilation.

Respiratory centers located within the medulla oblongata and pons of the brainstem are responsible for generating the baseline respiratory rhythm. However, the rate of respiration is modified by allowing for aggregated sensory input from the peripheral sensory system, which monitors oxygenation, and the central sensory system, which monitors pH and indirectly carbon dioxide levels along with several other portions of the cerebellar brain modulate to create a unified neural signal. The signal is then sent to the primary muscles of respiration, the diaphragm, external intercostals, and scalene muscles along with other minor muscles of respiration.[4]

History and Physical

The history and physical exam should ascertain whether there are any chronic underlying cardiovascular or pulmonary illnesses. Key components of history include onset, duration, aggravating factors, and alleviating factors. The presence of cough may indicate the presence of asthma, chronic obstructive pulmonary disease (COPD), or pneumonia. A severe sore throat could indicate epiglottitis. Pleuritic quality chest pain may indicate pericarditis, pulmonary embolism, pneumothorax, or pneumonia. Orthopnea, paroxysmal nocturnal dyspnea, and edema suggest a possible diagnosis of congestive heart failure. Tobacco use is a common history finding that increases the likelihood of COPD, congestive heart failure, and pulmonary embolism. If indigestion or dysphagia is present, consider gastroesophageal reflux disease or gastric secretion aspiration in the lungs. A barking quality cough, especially in children, may suggest croup. The presence of fever strongly suggests an infectious etiology.

The physical exam should begin with a rapid assessment of the ABCs (airway, breathing, and circulation). Once determined to be stable, a full physical exam can be done. To determine the severity of dyspnea, one needs to observe respiratory effort, use of accessory muscles, mental status, and ability to speak. Engorgement of the neck veins may imply cor pulmonale caused by severe COPD, congestive heart failure, or cardiac tamponade. Thyromegaly may indicate hyperthyroidism or hypothyroidism. Percussion of the lung lobes for dullness can determine the presence or absence of consolidation and effusion. Hyperresonance on percussion is a worrisome finding that indicates possible pneumothorax or severe bullous emphysema. Lung auscultation may reveal absent breath sounds indicating the presence of region occupying mass, such as pleural effusion or malignancy. The presence of wheezing is highly consistent with the diagnosis of obstructive lung diseases such as asthma or COPD. However, wheezing may be associated with pulmonary edema or pulmonary embolism. Pulmonary edema and pneumonia may present with rales on auscultation. Auscultation of the heart may reveal the presence of dysrhythmia, cardiac murmurs, or aberrant heart gallops. An S3 gallop indicates cardiac overfilling seen in left ventricular systolic dysfunction and congestive heart failure (CHF). An S4 gallop suggests left ventricular dysmotility and dysfunction. A loud P2 indicates possible pulmonary hypertension. Murmurs may indicate valvular dysfunction. Diminished heart sounds may indicate cardiac tamponade. Pericarditis may present with a rubbing cardiac sound on auscultation. On abdominal examination, hepatomegaly, ascites, positive hepatojugular reflux may suggest a diagnosis of CHF. Lower extremity edema is associated with CHF, and extreme swelling of the extremities suggests possible deep venous thrombosis that can lead to a pulmonary embolism. Digital clubbing is present in some forms of lung malignancy or severe chronic hypoxia. Cyanosis of the extremities indicates hypoxia.[5]

Evaluation

Every evaluation should begin with a rapid assessment of the ABC status of the patient. Once these are determined to be stable and no life-threatening status present, a complete history, and physical exam can be collected. Vital signs should be assessed for heart rate, respiratory rate, body temperature, body mass index (BMI), and oxygen saturation. Oxygen saturation may be normal at rest, so oxygen saturation with physical exertion should be obtained. In normal physiological conditions, the pulse oximetry improves as V/Q matching improves. Fever may indicate an infectious etiology. A chest x-ray is the first diagnostic test that should be utilized in evaluating dyspnea on exertion. If abnormal, the disease process is likely cardiac or a primary pulmonary process. An echocardiogram is needed to evaluate cardiac function, pericardial space, and valvular function.

Additionally, an electrocardiogram should be obtained to evaluate for myocardial infarction or right-sided heart pattern strain. Elevated pro-brain natriuretic peptide (BNP) levels can further a congestive heart disease diagnosis. Exercise stress testing is also beneficial to determine cardiac function along with exercise oxygenation. If the chest x-ray is normal, then spirometry is needed to determine lung function. Abnormal spirometry can indicate either an obstructive pathology such as asthma, COPD, or physical airway obstruction or restrictive disease processes such as interstitial fibrosis. Spirometry can also indicate the presence of respiratory muscle weakness from muscular or neurological abnormalities. Normal spirometry indicates a need to evaluate for hypoxia as a source of dyspnea. The restrictive pathology can be confirmed with lung volumes, which will show reduced total lung capacity (TLC). In obstructive lung disease, the TLC is increased, and the RV/TLC ratio is increased. Diffusion capacity is reduced in disease processes that affect the alveolar membrane area and or thickness. For example, it will be reduced with interstitial lung disease (ILD), emphysema, pulmonary embolism (PE), CHF, and obesity.

Arterial blood gas testing is used for this purpose as well as to calculate the A-a gradient and assess for an acidotic state. If PaO2 is low with a normal chest x-ray, then pulmonary embolism should be considered. The pH is mostly alkalotic in the setting of PE. This is to blow carbon dioxide to relatively increase the partial pressure of oxygen. In a pregnant female, d-dimer with leg ultrasound and V/Q scan should be ordered first. Detection of a mismatch in 2 or more areas indicates pulmonary embolism. D-dimer testing has low specificity and high sensitivity. Spiral CT of the chest is an alternative to V/Q scanning. In acute settings, the CT chest with PE protocol is the gold standard. If the dyspnea on exertion is chronic, then chronic thromboembolic pulmonary hypertension (CTEPH) should be considered, and the VQ scan is the test of choice and is considered the gold standard. The VQ scan in this setting has a “moth-eaten” appearance.

A normal scan necessitates cardiac catheterization to determine pulmonary hypertension, intracardiac shunting, or coronary artery disease. A normal cardiac catheterization diagnoses idiopathic dyspnea. If hypoxia is not present with a PaO2 greater than 70 mm Hg, correlation with oxygen saturation is needed. Abnormal oxygen saturation indicates possible carbon monoxide poisoning, methemoglobinemia, or an abnormal hemoglobin molecule.

Normal oxygen saturation requires a complete blood count (CBC) to evaluate hemoglobin content and hematocrit values. The white blood count also assesses for an immune response to possible infection. Hematocrit less than 35% is anemia.

  • Oxygen Delivery:  Hb x 1.39 x SaO2 x Cardiac Output + 0.003 x Pao2

If one cannot determine the etiology of dyspnea, then we should order a cardiopulmonary exercise test (CPET). If the CPET does not show any cardiac or pulmonary etiology, then the likely diagnosis for dyspnea on exertion is physical deconditioning.

All testing modalities should target clinical suspicion and the history and physical exam to avoid overtesting and minimize the cost to the patient.[6]

Treatment / Management

Treatment for dyspnea on exertion depends on its underlying etiology. The first intervention is to determine that there are no life-threatening etiologies present on an acute presentation by monitoring the ABCs (airway, breathing, and circulation) of the patient. Once determined to be stable and that no immediate lifesaving interventions are necessary, assessment for further treatment can be made. If a patient is a tobacco smoker, this should be discontinued. Various inhaler therapies may be used in respiratory disease, including short-acting or long-acting bronchodilators, inhaled antimuscarinics, and inhaled corticosteroids. Continuous supplemental oxygen therapy is used to ease discomfort associated with dyspnea on exertion if oxygen saturation is shown to decrease with exercise. [7] Cardiac function should be optimized when a cardiac illness is identified. If myocardial infarction is suspected based on ST changes on electrocardiogram or troponin marker evaluation, rapid percutaneous intervention should be performed by a cardiologist. Therapy with aspirin, statin, ACE inhibitor, beta-blocker, heparin, and nitrates should be initiated immediately if no contraindications. Occasionally, medications such as beta-blockers and calcium-channel blockers can induce dyspnea on exertion by decreasing cardiac function, which can be picked up on a CPET. These should be decreased or discontinued when possible. In CHF, diuretic medications should be used to decrease vascular congestion from fluid overloading. If the dyspnea on exertion is due to obesity or deconditioning physical therapy, an exercise regimen should be pursued. If psychological problems are causing dyspnea on exertion, a selective serotonin receptor inhibitor can be tried along with counseling sessions [8]. Weight loss in obese patients, especially women, will improve outcomes.[9]

Differential Diagnosis

Acute dyspnea on exertion is most likely caused by:

  • Acute myocardial ischemia
  • Heart failure
  • Cardiac tamponade
  • Pulmonary embolism
  • Pneumothorax
  • Pulmonary infection in the form of bronchitis or pneumonia
  • Upper airway obstruction by aspiration or anaphylaxis

Chronic dyspnea is most likely caused by:

  • Asthma
  • Chronic obstructive pulmonary disease
  • Congestive heart failure
  • Interstitial lung disease
  • Myocardial dysfunction
  • Obesity
  • Deconditioning

The most common diagnosis underlying dyspnea on exertion is CHF.

Prognosis

In itself, dyspnea on exertion is harmless and a normal physiological finding; however, as it is a symptom and not an illness, it may indicate an underlying disease. The prognosis is highly variable and depends on the underlying etiology and comorbidities.

Complications

If left untreated, dyspnea on exertion can progress to acute respiratory failure with hypoxia and/or hypercapnia, further leading to life-threatening respiratory or cardiac arrest or both.

Consultations

Based on possible underlying etiology after the initial evaluation, a cardiologist or a pulmonologist needs to be consulted.

Deterrence and Patient Education

Patients need to be educated about the gravity of dyspnea on exertion. They need to be advised to get immediate medical help for the recurrence of his symptoms, as this can be life-threatening. Patients with CHF need to be educated about fluid restriction, dietary modifications, daily weights, and compliance with medications, including diuretics, as advised. CHF management can be overwhelming for patients and can lead to emotional lability and even depression[10][11]. Patients need to be screened for mood disorders and referred to a psychiatrist if needed.

Enhancing Healthcare Team Outcomes

The most common cause of dyspnea on exertion is CHF. Management of CHF is complicated, and an interprofessional approach is very important. The patient and his family need to be educated by a specialty-trained nurse prior to discharge from the hospital. The patient needs close follow up with their primary care physician, cardiologist, heart failure nurse, and dietician. The patient would also benefit from home health services after discharge from the hospital to help monitor weight and make sure they are taking all their medications. This would help reduce hospital readmission.


References

[1] Mukerji V, Dyspnea, Orthopnea, and Paroxysmal Nocturnal Dyspnea 1990;     [PubMed PMID: 21250057]
[2] Bernhardt V,Babb TG, Respiratory symptom perception differs in obese women with strong or mild breathlessness during constant-load exercise. Chest. 2014 Feb;     [PubMed PMID: 23989732]
[3] Rawat D,Sharma S, Dyspnea 2018 Jan;     [PubMed PMID: 29763140]
[4] Guazzi M,Myers J,Peberdy MA,Bensimhon D,Chase P,Arena R, Ventilatory efficiency and dyspnea on exertion improvements are related to reduced pulmonary pressure in heart failure patients receiving Sildenafil. International journal of cardiology. 2010 Oct 29;     [PubMed PMID: 19329196]
[5] Marcus BS,McAvay G,Gill TM,Vaz Fragoso CA, Respiratory symptoms, spirometric respiratory impairment, and respiratory disease in middle-aged and older persons. Journal of the American Geriatrics Society. 2015 Feb;     [PubMed PMID: 25643966]
[6] Janssen R,Piscaer I,Franssen FM,Wouters EF, Emphysema: looking beyond alpha-1 antitrypsin deficiency. Expert review of respiratory medicine. 2019 Feb 14;     [PubMed PMID: 30761929]
[7] Parshall MB,Schwartzstein RM,Adams L,Banzett RB,Manning HL,Bourbeau J,Calverley PM,Gift AG,Harver A,Lareau SC,Mahler DA,Meek PM,O'Donnell DE, An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. American journal of respiratory and critical care medicine. 2012 Feb 15     [PubMed PMID: 22336677]
[8] Zhuravleva MV,Prokofiev AB,Shih EV,Serebrova SY,Gorodetskaya GI, [Novel Possibilities in Pharmacotherapy of Patients With Chronic Heart Failure]. Kardiologiia. 2018 Oct     [PubMed PMID: 30359220]
[9] Bernhardt V,Babb TG, Weight loss reduces dyspnea on exertion in obese women. Respiratory physiology & neurobiology. 2014 Dec 1     [PubMed PMID: 25220695]
[10] Zahid I,Baig MA,Ahmed Gilani J,Waseem N,Ather S,Farooq AS,Ghouri A,Siddiqui SN,Kumar R,Sahil,Suman,Kumar R,Kumar R,Mulla AA,Siddiqi R,Fatima K, Frequency and predictors of depression in congestive heart failure. Indian heart journal. 2018 Dec     [PubMed PMID: 30595257]
[11] Marines-Price R,Bernhardt V,Bhammar DM,Babb TG, Dyspnea on exertion provokes unpleasantness and negative emotions in women with obesity. Respiratory physiology & neurobiology. 2019 Feb     [PubMed PMID: 30471435]