Diverticulitis has increased in incidence over the past few decades, becoming a major healthcare burden for Western countries. In the United States, acute diverticulitis results in nearly 200000 hospital admissions and $2.2 billion of health care costs per year. Although the prevalence of the disease increases with age, younger adults may also develop diverticular disease. In fact, for some time, it was thought that younger patients and male patients were more likely to experience a more aggressive form of diverticulitis with an increased complication rate and higher recurrence. However, recent studies have challenged this concept. Environmental and genetic risk factors result in the development of the diverticular disease, although good quality evidence for many of these factors remains insufficient. Most cases of diverticulitis undergo successful management in the outpatient setting with oral antibiotics and temporary dietary restrictions. The decision to perform elective sigmoid colectomy in patients that recover from uncomplicated diverticulitis is controversial and requires case-by-case consideration. Surgical treatment is the recommendation in cases of complicated diverticulitis.
The diverticular disease starts with an out-pouching of the mucosa of the colonic wall. Inflammation at each mucosal out-pouching contributes to diverticulitis. The presumed mechanism of diverticulitis is an overgrowth of bacteria due to obstruction of the diverticular base by feces with micro-perforations. This theory has been challenged in recent years as some studies demonstrate that in selected cases, resolution of uncomplicated diverticulitis may occur without antibiotics.
Diverticulosis of the colon is common in western countries and increases with age. Over 50% of individuals over the age of sixty have diverticulosis, and the incidence rises to 70% after eighty years of age. Despite the significant prevalence of diverticulosis in the population, only 4% of individuals will develop diverticulitis in their lifetime. The distribution of the colonic diverticula varies depending on population demographics. In Western countries, diverticula are most common in the sigmoid colon with a rate of 65%. The right colon is more commonly involved in Asian populations. This difference was once attributed to daily dietary fiber, but epidemiologic studies have refuted this concept. These studies have analyzed Asian populations after relocation and change in dietary habits, but there is not yet proof of any change in the diverticular pattern. Although environmental factors play a significant role in the development of diverticulosis, studies on identical twins have identified a strong genetic predisposition.
Multiple environmental risk factors have been postulated in the development of diverticular disease; however, many remain controversial. A 1970 study hypothesized that a diet high in fiber was protective against diverticular disease, but evidence in this regard is conflicting. For patients with a history of diverticulitis, The American Gastroenterology Association (AGA) and American Society of Colon and Rectal Surgeons (ASCRS) recommend a diet high in fiber. In this setting, increasing dietary fiber correlates with a reduction in the development of recurrent episodes of acute uncomplicated and complicated diverticulitis
In the past, patients with the diverticular disease were discouraged from eating nuts, seeds, and popcorn, but a recent study determined that these foods do not increase the risk of developing diverticulitis. Red meat, particularly beef and lamb, have been associated with an increased risk of hospitalization for diverticulitis. Obesity, smoking, and alcohol use are also associated with a higher incidence of diverticular disease. Medications, including NSAIDs, aminosalicylates (ASA), and acetaminophen, seem to increase the risk of developing complicated diverticulitis. Current corticosteroid use doubles the risk of developing perforated diverticulitis.
There are also postulates regarding protective factors. Vigorous exercise, such as running, has shown a risk reduction for the development of complicated diverticulitis by 25%. Light activity, such as walking, is less effective. Statin medications appear to reduce the risk of perforated diverticulitis. Maintaining a normal weight and eliminating smoking also decreases the risk of diverticular disease.
Despite the high prevalence of diverticulosis, the pathophysiology of the disease is not well understood. A colonic diverticulum is an out-pouching of the colonic mucosa through the weakest point in the colonic lumen, where the vasa recta penetrate the colonic wall to supply blood to the submucosa and mucosa. Patients with diverticulosis have increased intraluminal pressures during peristalsis. High colonic intraluminal pressure associated with constipation and straining during defecation was once thought to be the initiating factor resulting in mucosal herniation through the colonic wall, but this theory is currently under question.
Most patients with diverticulosis are asymptomatic, and the presence of diverticula is commonly identified incidentally during colonoscopy or radiologic studies. Patients with acute diverticulitis may present with fever, left lower quadrant pain, and change in bowel habits. Left lower abdominal pain is the most common presenting feature in 70% of patients. The character of the pain is mostly described as crampy and may be associated with a change in bowel habits. Consequently, the presentation of diverticulitis may be confused with irritable bowel syndrome. Other symptoms of diverticulitis include nausea, vomiting, constipation, flatulence, and bloating. Acute presentation of diverticulitis may also be because of a complication, such as colonic abscess, intestinal perforation, and fistula formation.
Laboratory findings include leukocytosis and possibly elevated inflammatory markers. Those patients with complicated diverticulitis may present with signs of sepsis and physical findings consistent with peritonitis. Physical findings may include abdominal tenderness, abdominal distension, a tender mass in the abdomen, absent bowel sounds, and findings related to fistula formation. The presence of fecaluria and pneumaturia must alert the clinician to the possibility of a colovesical fistula.
When the history, physical exam, and laboratory findings are consistent with the diagnosis of acute diverticulitis, confirmatory imaging studies are the next step. Different imaging modalities, including ultrasound and barium enema, may be used to diagnose diverticular disease. However, a CT scan of the abdomen and pelvis with intravenous and oral contrast is the preferred modality. Its diagnostic accuracy is high, with a sensitivity of 98%. assessment of renal function prior to the administration of intravenous contrast is imperative. Findings of colonic wall thickening and fat stranding are typical for diverticulitis. Signs of complicated disease, including fistula formation, abscesses, and intra-abdominal free air, are easily identifiable with scans. The Hinchey classification system is useful in determining the severity of disease as well as in the allocation of patients to different treatment algorithms.
Generally speaking, patients with Hinchey 1a and 1b diverticulitis are successfully manageable by non-surgical means. Patients with Hinchey 2 diverticulitis may require placement of a percutaneous drain followed by elective sigmoid colectomy. However, patients with Hinchey 3 and 4 require urgent surgical intervention.
If there is a suspicion of a colovesical fistula, the urinalysis may reveal red or white blood cells. In females of childbearing age who present with abdominal pain, a pregnancy test must be carried out to rule out an ectopic pregnancy.
The medical management of acute non-complicated diverticulitis includes oral or intravenous antibiotics, pain control, hydration, and restricted oral intake. Medical management of diverticulitis with antibiotics remains the standard of care. However, antibiotic choice, duration of treatment, and route of administration remain controversial. Most cases of uncomplicated diverticulitis are successfully treatable in the outpatient setting. Oral antibiotics, such as ciprofloxacin and metronidazole or amoxicillin-clavulanate, are prescribed for 7 to 10 days with recommendations to minimize oral intake until the pain has resolved.
Patients who are febrile, immunosuppressed, unable to stay hydrated or those with multiple medical comorbidities require admission to the hospital for treatment with parenteral antibiotics. As symptoms improve, the diet is advanced, and patients are started on oral antibiotics. Any patient failing to improve on parenteral antibiotics or deteriorates during therapy should undergo repeat evaluation with CT imaging to rule out evolving complications.
After acute episode resolution of diverticulitis, a colonoscopy is recommended 6 to 8 weeks later, particularly if the patient has not had a colonoscopy in the past 2 to 3 years.
Historically, elective sigmoid colectomy used to be performed after the second bout of uncomplicated diverticulitis. However, more recent evidence has disproved the benefit of this approach. Firstly, the recurrence rate of uncomplicated diverticulitis is lower than previously estimated, ranging from 13 to 23%. Secondly, the incidence of complicated recurrent episodes that may require a stoma is also low, approximately 6%. Therefore, current recommendations emphasize that selection criteria for elective surgery should be individualized according to the number, severity, and frequency of episodes of diverticulitis, persistent symptomatology after an episode of diverticulitis and the immunologic status of the patient. These criteria merit consideration in the context of the patient’s age, comorbidities, and social history. Finally, routine sigmoid colectomy in patients younger than 50 years of age is no longer the recommended therapeutic path. Younger patients should receive the same treatment as their older counterparts.
Regardless of the indication and or technique used (open, laparoscopic, or robotic) when performing an elective sigmoid colectomy for diverticulitis, it requires the removal of the entire sigmoid colon, the proximal and distal anastomotic sites must appear healthy and well perfused, and the anastomosis performed without tension.
Approximately 1% of patients with an acute episode of diverticulitis will require surgical intervention during that episode. Patients presenting with signs of peritonitis are candidates for emergent surgery. When intraoperative findings confirm perforated diverticulitis, the traditional operation is a Hartmann procedure, which includes resection of the sigmoid colon, preservation of the rectum in the form of a rectal pouch, and creation of an end colostomy. This procedure effectively eliminates the risk of an anastomotic leak, and patients are considered for colostomy reversal in 3 to 6 months. However, due to old age and associated comorbidities, nearly 30% of patients undergoing a Hartmann procedure never have colostomy reversal. A second option for patients with Hinchey 3 and 4 diseases is a primary colorectal anastomosis with a proximal diverting ileostomy. Initial retrospective evaluation of this surgical modality shows a decreased overall mortality after performing a primary anastomosis. However, randomized controlled studies comparing a Hartmann procedure to the primary anastomosis with proximal diversion are not yet available. An old approach, no longer considered in the surgical management of complicated diverticulitis, consisted of leaving the inflamed or perforated sigmoid colon in situ and placement of a proximal stoma with the plan of second and then third stage procedures.
Diverticulitis can occur anywhere in the colon; hence, the presentation may vary according to the site involved. For instance, diverticulitis in the right colon may present in a similar fashion to acute appendicitis. Similarly, diverticula in the transverse colon may appear as peptic ulcer disease, pancreatitis, or cholecystitis. Therefore the list of differential diagnoses is extensive as follows:
Recent studies have demonstrated the resolution of uncomplicated diverticulitis without the use of antibiotics in very well-selected patients. Patients with peritonitis, perforation, signs of sepsis, and hemodynamic instability were excluded. Although some patients did develop perforations or abscesses, the risk was considered low, and there was no difference in primary outcomes between the group treated with antibiotics and the group without antibiotic therapy. The evidence for this unique treatment approach is preliminary, and further study is needed.
Traditionally, patients with generalized peritonitis from perforated diverticulitis undergo a Hartman procedure or primary anastomosis with a proximal diverting stoma. Researchers have studied laparoscopic peritoneal lavage as an alternative to the standard surgical treatment of perforated diverticulitis. Other studies have not duplicated the initial results, so this treatment remains controversial.
The prognosis of the patients depends on the severity of the illness and the presence of complications. Immunocompromised patients have higher morbidity and mortality as a result of sigmoid diverticulitis.
After the first incident of acute diverticulitis, the five-year recurrence rate is approximately 20%. Several studies have demonstrated the significant link between increased BMI and the risk of developing diverticulitis.
There are many complications that can occur in a patient with diverticulitis which can be more severe in certain cases, such as in immunocompromised patients. For instance, those infected with HIV or those on immunosuppressants are more likely to develop perforation. Following are the possible complications of diverticulitis:
The present management of diverticulitis must be delivered by interprofessional teams in the context of the most recent scientific evidence. These teams can include gastroenterologists, internists, general surgeons, colostomy care nurses, gastroenterology specialty-trained nurses, and pharmacists, working collaboratively to bring about optimal patient care and outcomes.
The incidence of diverticulitis continues to increase in all age groups, placing a substantial burden on the healthcare system. The primary care physician, nurse practitioner, gastroenterologist, and the dietitian must educate the public and patients that obesity, inactivity, and a poor diet contribute significantly to epidemiologic factors.
A positive paradigm change in the treatment of diverticulitis has resulted in the widespread use of outpatient management for non-complicated diverticulitis. However, many patients with a history of non-complicated diverticulitis are improperly managed empirically with antibiotics every time they call their doctor’s office with abdominal pain. This misuse of antibiotics must be corrected. For patients undergoing surgery, a colostomy nurse should educate the patient on the care of the stoma.
Better and more sophisticated imaging modalities have allowed us to accurately classify the severity of disease and allocate different patients to more effective treatment algorithms.
The current emphasis on individualizing the need for elective sigmoid colectomy after resolving non-complicated diverticulitis will result in less unnecessary operations and better outcomes. [Level V]
|||Munie ST,Nalamati SPM, Epidemiology and Pathophysiology of Diverticular Disease. Clinics in colon and rectal surgery. 2018 Jul; [PubMed PMID: 29942208]|
|||Peery AF,Crockett SD,Barritt AS,Dellon ES,Eluri S,Gangarosa LM,Jensen ET,Lund JL,Pasricha S,Runge T,Schmidt M,Shaheen NJ,Sandler RS, Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States. Gastroenterology. 2015 Dec; [PubMed PMID: 26327134]|
|||Lahat A,Menachem Y,Avidan B,Yanai H,Sakhnini E,Bardan E,Bar-Meir S, Diverticulitis in the young patient--is it different ? World journal of gastroenterology. 2006 May 14; [PubMed PMID: 16718822]|
|||Schieffer KM,Kline BP,Yochum GS,Koltun WA, Pathophysiology of diverticular disease. Expert review of gastroenterology [PubMed PMID: 29846097]|
|||Everhart JE,Ruhl CE, Burden of digestive diseases in the United States part II: lower gastrointestinal diseases. Gastroenterology. 2009 Mar; [PubMed PMID: 19166855]|
|||Shahedi K,Fuller G,Bolus R,Cohen E,Vu M,Shah R,Agarwal N,Kaneshiro M,Atia M,Sheen V,Kurzbard N,van Oijen MG,Yen L,Hodgkins P,Erder MH,Spiegel B, Long-term risk of acute diverticulitis among patients with incidental diverticulosis found during colonoscopy. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2013 Dec; [PubMed PMID: 23856358]|
|||Strate LL, Lifestyle factors and the course of diverticular disease. Digestive diseases (Basel, Switzerland). 2012; [PubMed PMID: 22572683]|
|||Rezapour M,Ali S,Stollman N, Diverticular Disease: An Update on Pathogenesis and Management. Gut and liver. 2018 Mar 15; [PubMed PMID: 28494576]|
|||Painter NS,Burkitt DP, Diverticular disease of the colon: a deficiency disease of Western civilization. British medical journal. 1971 May 22; [PubMed PMID: 4930390]|
|||Feingold D,Steele SR,Lee S,Kaiser A,Boushey R,Buie WD,Rafferty JF, Practice parameters for the treatment of sigmoid diverticulitis. Diseases of the colon and rectum. 2014 Mar; [PubMed PMID: 24509449]|
|||Strate LL,Liu YL,Syngal S,Aldoori WH,Giovannucci EL, Nut, corn, and popcorn consumption and the incidence of diverticular disease. JAMA. 2008 Aug 27; [PubMed PMID: 18728264]|
|||Manousos O,Day NE,Tzonou A,Papadimitriou C,Kapetanakis A,Polychronopoulou-Trichopoulou A,Trichopoulos D, Diet and other factors in the aetiology of diverticulosis: an epidemiological study in Greece. Gut. 1985 Jun; [PubMed PMID: 3924745]|
|||Humes DJ,Fleming KM,Spiller RC,West J, Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study. Gut. 2011 Feb; [PubMed PMID: 20940283]|
|||Böhm SK,Kruis W, Lifestyle and other risk factors for diverticulitis. Minerva gastroenterologica e dietologica. 2017 Jun; [PubMed PMID: 28150481]|
|||Young-Fadok TM, Diverticulitis. The New England journal of medicine. 2018 Oct 25; [PubMed PMID: 30354951]|
|||Laméris W,van Randen A,Bipat S,Bossuyt PM,Boermeester MA,Stoker J, Graded compression ultrasonography and computed tomography in acute colonic diverticulitis: meta-analysis of test accuracy. European radiology. 2008 Nov; [PubMed PMID: 18523784]|
|||Kandagatla PG,Stefanou AJ, Current Status of the Radiologic Assessment of Diverticular Disease. Clinics in colon and rectal surgery. 2018 Jul; [PubMed PMID: 29942210]|
|||Huston JM,Zuckerbraun BS,Moore LJ,Sanders JM,Duane TM, Antibiotics versus No Antibiotics for the Treatment of Acute Uncomplicated Diverticulitis: Review of the Evidence and Future Directions. Surgical infections. 2018 Oct; [PubMed PMID: 30204549]|
|||Zoog E,Giles WH,Maxwell RA, An Update on the Current Management of Perforated Diverticulitis. The American surgeon. 2017 Dec 1 [PubMed PMID: 29336748]|
|||Shaban F,Carney K,McGarry K,Holtham S, Perforated diverticulitis: To anastomose or not to anastomose? A systematic review and meta-analysis. International journal of surgery (London, England). 2018 Oct [PubMed PMID: 30165109]|
|||Angenete E,Bock D,Rosenberg J,Haglind E, Laparoscopic lavage is superior to colon resection for perforated purulent diverticulitis-a meta-analysis. International journal of colorectal disease. 2017 Feb; [PubMed PMID: 27567926]|
|||Brandl A,Kratzer T,Kafka-Ritsch R,Braunwarth E,Denecke C,Weiss S,Atanasov G,Sucher R,Biebl M,Aigner F,Pratschke J,Öllinger R, Diverticulitis in immunosuppressed patients: A fatal outcome requiring a new approach? Canadian journal of surgery. Journal canadien de chirurgie. 2016 Aug [PubMed PMID: 27240131]|
|||Peery AF, Recent Advances in Diverticular Disease. Current gastroenterology reports. 2016 Jul [PubMed PMID: 27241190]|
|||Strate LL,Liu YL,Aldoori WH,Syngal S,Giovannucci EL, Obesity increases the risks of diverticulitis and diverticular bleeding. Gastroenterology. 2009 Jan [PubMed PMID: 18996378]|
|||Jacobs DO, Clinical practice. Diverticulitis. The New England journal of medicine. 2007 Nov 15 [PubMed PMID: 18003962]|