Tinea manuum is a superficial mycosis of the palm, dorsum, or interdigital folds of one or both hands. It is usually caused by dermatophytes, although rare cases caused by Hendersonula toruloidea and Scytalidium hyalinum have been reported in the literature.
Tinea manuum frequently coexists with tinea pedis, but occasionally, localized forms may affect the hands exclusively. Tinea manuum is distributed worldwide, and, as with other dermatophytoses, other people (anthropophilic), animals (zoophilic), and soil (geophilic) are the most common sources in the United States.
Tinea manuum is caused by dermatophytes, and the most common agent worldwide is Trichophyton rubrum. However, different etiologic organisms have been reported in various geographical locations.
Other involved dermatophytes are Trichophyton mentagrophytes, Epidermophyton floccosum, Trichophyton verrucosum, Trichophyton interdigitale, Microsporum canis.
Microsporum gypseum, Trichophyton eriotrephon, and Arhroderma benhamiae have also been described, but more rarely.
Risk factors and predispositions for Tinea infections and onychomycosis include:
An estimated 10% to 25% of the world’s population is infected by a dermatophyte. Of these infections, tinea pedis and manuum are the most common clinical presentations with tinea pedis occurring in up to 70% of adults.
There are many epidemiological studies on tinea pedis, but little research is available on the epidemiology of tinea manuum. The rate of tinea manuum can range from 0.3-13% with the variability based upon geographic location.
One study of collected cases of tinea manuum showed that “the two feet, one hand syndrome” is the most frequent (65%) clinical presentation, followed by bilateral tinea pedis with bilateral tinea manuum (19.3%), unilateral tinea manuum (11.8%), and bilateral tinea manuum (3.9%).
Adolescent and adult males are the more commonly affected populations.
Differences in susceptibility, even when individuals have the same risk factors to fungal infection, provide evidence about the complex interaction between the host, agent, and the environment. Recently, the immune-genetic predispositions for more severe, invasive disease have been described in the literature with specific defects in the innate and adaptative immunity. The cell-mediated immune response is currently accepted as being responsible for the infection control of dermatophytes.
Acquired immunosuppression, as in HIV/AIDS, lymphoma, diabetes, older age, Cushing's syndrome, or use of chemotherapy or other immunosuppressive agents, predisposes the host to tinea infection. Web spaces, excess sweating, and maceration also create a more hospitable environment for better fungal growth.
Mannan glycoproteins mediate the adherence of dermatophytes to the keratin-containing epithelial tissue of the host, and then proteases digest the keratin network to facilitate penetration. T. rubrum cell wall mannan has also been shown to suppress lymphocyte response.
Dermatophytes invade and infect the stratum corneum and may persist there. The skin responds to the superficial infection via the increased proliferation of keratinocytes and the production of scales. The epidermal hyperkeratosis clinically manifests as a thickening of the skin.
Histologic findings are similar for all dermatophyte infections. A skin biopsy will demonstrate epidermal spongiosis, parakeratosis, and a superficial inflammatory infiltrate. Clusters of neutrophils in the stratum corneum are considered an important clue for the diagnosis. Nonpigmented, regular, septated hyphae might be seen in the stratum corneum, but this is best identified with periodic acid-Schiff (PAS) or Gomori methamine silver (GMS) stains.
Tinea manuum might be asymptomatic, or patients can complain of thickened skin or pruritis. Infection is usually unilateral, but it can also affect both hands. The dorsum of the hand will show a similar morphology as in tinea corporis, characterized by a red plaque with an active vesicular and scaly border and a centrifugal growth. Several concentric rings might be seen (fig 1) (fig 2). Palmar surfaces usually have a dry, scaling appearance (fig 3).
The most common clinical presentation is an entity known as “two-foot, one hand syndrome.” In this case, both feet are affected, and one hand presents with scaly patches or moderate to severe, diffuse dryness. In some patients, onychomycosis can be present in the same hand or even in both hands.
Zoophilic dermatophyte infections must be suspected when inflammatory lesions with pustular or vesicular plaques on a highly erythematous base are seen, especially if the lesions are localized to one hand. Patients can describe pain, itch, and swelling, and rare cases might include local lymphangitis.
Once a detailed medical history and clinical inspection suggest tinea manuum, mycological confirmation must be obtained. Some authors suggest that the gold standard for detecting a fungal infection must be a triple confirmation that includes: clinical exam, KOH, and culture.
Other methods of dermatophyte differentiation, such as PCR, real-time PCR, and newer molecular methods, are being used in large institutions and for research purposes.
Several topical and systemic antifungal therapy options and regimens are available. When possible, topical therapy is preferred for tinea manuum due to the risk of drug interactions and side effects of the oral treatments.
The differential diagnosis for tinea manuum includes various cutaneous diseases as well as bacterial, viral, and other fungal infections.
Psoriasis: usually bilateral and hyperkeratotic with thickened palms and soles. Patches of unaffected skin are commonly seen, and vesicular lesions, ungual pitting, and oil drop sign also can be found.
Dyshidrotic eczema: characterized by vesicles in the edges of the fingers, toes, palms, and soles that are very pruriginous and may be related to stress or seasonal allergies.
Contact dermatitis: irritant and allergic varieties are an inflammatory condition with erythematous and pruritic skin lesions that can affect palms and dorsum of hands, usually bilateral. The patient might describe that skin lesions occur after contact with a foreign substance, e.g., poison ivy or nickel.
Making the correct diagnosis and gaining compliance with an appropriate treatment regimen is critical to effecting a mycological cure. Some treatments might require several weeks, so noncompliance is a common reason for treatment failure.
Relapse or recurrence after therapy remains a concern. Infection transmission from symptom-free carriers, like family and pets, needs to be identified. Adjuvant therapies might be required for adequate control of infection in the treatment-refractory patient and in the carriers, and disinfectant techniques should be employed to control exposure via fomites.
In general, most complications are due to delays in consultation and diagnosis. Medical evaluation sometimes occurs as late as months to years after the skin lesion appears.
Secondary bacterial infection and lymphangitis have been described in cases of inflammatory tinea manuum, especially in those due to a zoonotic dermatophyte.
Contact dermatitis due to topical imidazole antimycotic therapy has been described as a rare complication of its use.
A case of disuse contractures of the flexor tendons has been reported in a patient with tinea manuum and irritant contact dermatitis.
Primary care physicians/providers will usually make the diagnosis and establish treatment; however, some cases can be challenging and might require a referral to a dermatologist and/or to an infectious disease specialist, especially in chronic or recurrent cases or for patients in whom underlying skin disease is suspected.
Education of patients must focus on:
Hygiene: wash hands more frequently to help remove pathogens on the surface of the hands.
Avoid scratching the feet or touching onychomycosis.
Treat tinea pedis in time to prevent it from spreading from the feet to the hands.
Identify and treat possible contacts.
Encourage treatment compliance and avoid self-treatment with topical corticosteroids and antibiotics. These additional and often unnecessary treatments can delay the correct diagnosis.
Early diagnosis and treatment are essential in decreasing morbidity and facilitating manual function. Primary care providers should be able to treat most cases of tinea manuum; however, if there is an uncertain diagnosis or an inadequate response to therapy, the patient should be referred to a dermatologist. A referral is also prudent if immunodeficiency is suspected or diagnosed as a predisposing factor in the development of tinea manuum.
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