Continuing Education Activity
There are currently three cannabinoids available on the pharmaceutical market. Dronabinol and nabilone are both synthetic tetrahydrocannabinol (THC) which the FDA has approved for the treatment of chemotherapy-induced nausea and vomiting (CINV) after the failure of a trial of first-line anti-emetics. Both are also FDA approved to treat anorexia associated with AIDS. Recently, the FDA has also approved a cannabidiol (CBD) product to treat seizures associated with Lennox-Gastaut syndrome and Dravel syndrome in pediatric patients. However, there is no FDA approved indication for its use as an anti-emetic. This activity reviews the mechanism of action, adverse event profile, toxicity, dosing, pharmacodynamics, and monitoring of cannabinoid antiemetics, pertinent for clinicians and other members of the interprofessional team to ensure the appropriate utilization of these drugs.
- Identify the indications, both approved and off-label, of cannabis-based antiemetics.
- Review the mechanism of action of cannabis-based antiemetics.
- Outline the potential adverse effects of cannabinoid antiemetics.
- Summarize the importance of collaboration and communication among interprofessional team members to improve outcomes and treatment efficacy for patient receiving treatment with the cannabinoid antiemetic class of medications.