Virchow's triad consists of three factors that may predispose a person to the development of venous thrombosis. These factors include:
Historically, Rudolf Virchow, a nineteenth-century Berlin scientist, and physician is credited with recognition of these factors due to his extensive work on venous thrombosis. These concepts are also relevant to the development of arterial thrombosis.
Rudolf Virchow was one of the first physicians to examine disease at the cellular level, believing that most diseases, including pathological thrombosis, were caused by cellular pathology. Known as the "father of modern pathology," Virchow was a physician, scientist, anthropologist, prehistorian, and biologist in addition to his endeavors in pathology. He received credit for his work in cell biology, early cancer research, and for recognizing that the left supraclavicular lymph node (now called Virchow's node), when enlarged and hard to palpation, is associated with gastric cancer. Charles Emile Troisier later recognized the further association of other abdominal cancers as well as testicular cancer with the presence of Virchow's node. Virchow sought to explain the causation of pulmonary thromboembolism and theorized that pulmonary arterial embolus arises from peripheral/distant thrombosis. He attempted to explain the mechanism or define what specific conditions were necessary to initiate peripheral clotting and how a thrombus may dislodge from a peripheral vein, travel to the right heart, and then enter the pulmonary arterial system. The three factors of Virchow's triad include intravascular vessel wall damage, stasis of flow, and the presence of a hypercoagulable state. Understanding the factors involved in the thrombus formation and subsequent thromboembolic events enables the clinician to stratify risk, direct clinical decision making regarding treatment, and establish preventative measures.
Thrombosis, by definition, is the formation of a clot within a blood vessel. As described, Virchow’s triad represents three qualities in physiology that can result in thrombosis, which can lead to pathologies such as pulmonary embolism and deep venous thrombosis. These include:
The function of Virchow's triad is to demonstrate the underlying physiology that drives the formation of venous thrombus. Formation of clots within the vasculature places the patient at risk for thromboembolic events such as CVA, pulmonary arterial embolus or organ infarction, ischemia, and cell death. Understanding the physiology enables clinicians to understand better the risk factors for the development of deep vein thrombosis.
Given the serious nature of venous thrombosis, other interprofessional healthcare team members, including nurses, mid-level providers, and specialists, should be familiar with Virchow's triad and be able to recognize the presentation when examining or otherwise interacting with patients. Prompt recognition can lead to further testing and specialized intervention that can result in better patient outcomes.
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