Anatomy, Bony Pelvis and Lower Limb, Sural Nerve


The sural nerve is a cutaneous nerve, providing only sensation to the posterolateral aspect of the distal third of the leg and the lateral aspect of the foot, heel, and ankle. It is formed by terminal branches of the tibial and common peroneal nerves that join together in the superficial aspect of the distal third of the leg. It is purely sensory and easily located anatomically, making it a commonly used site for peripheral nerve biopsies and harvesting for nerve grafting.

Structure and Function

The sural nerve forms from the combination of two smaller sensory nerves: the medial sural cutaneous nerve, and the lateral sural cutaneous nerve. The medial sural cutaneous nerve is a terminal branch of the tibial nerve, and the lateral sural cutaneous nerve is a terminal branch of the common peroneal nerve. The union occurs in the distal third of the posterior leg, and the nerve then travels posterolaterally between the two heads of the gastrocnemius aside the short saphenous vein, becoming superficial around the mid-calf. It reaches the lateral malleolus lateral to the Achilles tendon, passing it 2.5 cm posteriorly before running deep to the fibularis tendon sheath and reaching the lateral tuberosity of the fifth toe. At the level of the ankle, the sural nerve and small saphenous vein run posteriorly between the calcaneus and lateral malleolus. The nerve is the preferred site for a biopsy if a peripheral nerve biopsy is necessary.[1][2]  


The neural plate forms during the third week after fertilization and creates the neural tube and neural crest cells. The neural crest cells become peripheral nerves, including the sural nerve. Schwann cells also derive from neural crest cells and myelinate nerves in the peripheral nervous system to increase the conduction of electrical signals.

Blood Supply and Lymphatics

Vascular supply to peripheral nerves intrinsically comes from the vasa nervorum within the epineurium of the nerve and extrinsically from parallel running arteries.


The sural nerve has its origins within the sciatic nerve, coming from terminal branches of the tibial and common fibular nerves. The medial sural cutaneous nerve, a terminal branch from the tibial nerve, joins with the lateral sural cutaneous nerve, a terminal branch from the common fibular nerve, to form the sural nerve in the distal third of the calf. The nerve roots commonly involved are S1 and S2.


The sural nerve does not innervate any muscle groups as it only provides sensory innervation of the skin. It does, however, travel subcutaneously between the two heads of the gastrocnemius.

Physiologic Variants

The variability of the sural nerve comes from how and where the lateral sural cutaneous nerve and the lateral sural cutaneous nerve fuse, the contribution of the fibular and tibial branch (as it can form from only one of these), and differences between each lower extremity within even a single person.[3][4][5]

Surgical Considerations

For surgeries involving the foot and ankle, the surgeon may use a sural nerve block as an adjunct to general anesthesia. It is relatively easy to perform as the nerve lies very superficial at the ankle and is locatable using anatomical landmarks, though ultrasound guidance is also an option. Risks are similar to those of any nerve block, including pain on injection, bleeding, infection, and allergic reaction to the anesthetic.[3]

The sural nerve can suffer an injury during procedures involving the ankle, calcaneal tendon, or small saphenous vein. The saphenous vein often gets harvested in coronary artery bypass procedures, and the proximity of the sural nerve to this vein predisposes it to injury during the harvesting procedure. Researchers have conducted several studies on the anatomical variability of the nerve as they may pertain to the surgical and clinical outcomes of procedures near the nerve. As it is not a motor nerve and only supplies sensation to a small part of the leg and foot, injury is well tolerated, and this is why the nerve is often used for nerve grafting or biopsy.[6][5]

Clinical Significance

Sural nerve entrapment[7]

Entrapment of the sural nerve is most often caused by fascial thickening at the site where the nerve becomes superficial to the gastrocnemius, called the superficial sural aponeurosis. A patient with sural nerve entrapment will present with sensory changes in the area the nerve innervates. There can be burning pain, hyperaesthesia, dysaesthesia, or paraesthesia in the region of the postero-lateral distal leg and lateral foot to the fifth digit. The area of entrapment may also be tender on examination. It must be distinguished from sciatica originating from sacral roots, exertional compartment syndrome, piriformis syndrome, and popliteal artery entrapment as these would present similarly. Decompression can be completed surgically by releasing the fascia that is compressing the nerve.

Sural nerve biopsy[8][9]

In patients with peripheral neuropathy that has no clear underlying cause, a sural nerve biopsy may help discover the histopathological etiology. It is not often used in modern medicine due to advances of less invasive technology such as electrophysiological and genetic testing. A biopsy may still be useful in cases where these newer methods provide no answer or a muddled picture; there is still a place for biopsy in cases such as vasculitic neuropathy, amyloid neuropathy, and multifocal leprosy. The sural nerve is a great candidate for biopsy as it is superficial and easily found anatomically, is purely sensory, and permanent anesthesia to its distribution is not likely to cause long-term patient harm. Possible complications include irritation, allodynia, and infection to the surgical wound. The more of the nerve that is taken out relates directly to the amount of sensory loss and recovery of the sensory deficit. However, in one study by Bevilacqua et al., 91% of those who had a section of the nerve had recovered the sensory deficit by 18 months.

Sural nerve graft[10]

Nerve grafts are used to replace or bridge a section of an injured or resected nerve, creating a sort of "track" for the injured nerve axons to grow along to reach the target area. The sural nerve is an excellent candidate as it is sensory-only, easy to harvest, and can provide a decent length of graft tissue. Though sensory deficits were somewhat large after grafting, a study by Butler et al. showed that patients had low postoperative pain and minimal functional deficit after endoscopic resection of the nerve. The study's findings support the continued use of the sural nerve as a common source of nerve grafts.

(Click Image to Enlarge)
Sural nerve
Sural nerve
Image courtesy S Bhimji MD
Article Details

Article Author

Mohammed Miniato

Article Editor:

Nicholas Nedeff


8/15/2020 11:35:29 PM



Tang A,Bordoni B, Anatomy, Bony Pelvis and Lower Limb, Foot Nerves 2019 Jan;     [PubMed PMID: 30725977]


Lawrence SJ,Botte MJ, The sural nerve in the foot and ankle: an anatomic study with clinical and surgical implications. Foot     [PubMed PMID: 7820241]


Popieluszko P,Mizia E,Henry BM,PĘkala PA,Sanna B,Roy J,Loukas M,Tomaszewski KA, The surgical anatomy of the sural nerve: An ultrasound study. Clinical anatomy (New York, N.Y.). 2018 May;     [PubMed PMID: 29044711]


Jeon SK,Paik DJ,Hwang YI, Variations in sural nerve formation pattern and distribution on the dorsum of the foot. Clinical anatomy (New York, N.Y.). 2017 May;     [PubMed PMID: 28281304]


Eid EM,Hegazy AM, Anatomical variations of the human sural nerve and its role in clinical and surgical procedures. Clinical anatomy (New York, N.Y.). 2011 Mar;     [PubMed PMID: 20949489]


Apaydin N,Bozkurt M,Loukas M,Vefali H,Tubbs RS,Esmer AF, Relationships of the sural nerve with the calcaneal tendon: an anatomical study with surgical and clinical implications. Surgical and radiologic anatomy : SRA. 2009 Dec;     [PubMed PMID: 19479178]


Paraskevas GK,Natsis K,Tzika M,Ioannidis O, Fascial entrapment of the sural nerve and its clinical relevance. Anatomy     [PubMed PMID: 24987554]


Pant I,Jha K,Singh R,Kushwaha S,Chaturvedi S, Peripheral neuropathy and the role of nerve biopsy: A revisit. Indian journal of pathology     [PubMed PMID: 30004051]


Bevilacqua NJ,Rogers LC,Malik RA,Armstrong DG, Technique of the sural nerve biopsy. The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons. 2007 Mar-Apr;     [PubMed PMID: 17331876]


Butler DP,Johal KS,Wicks CE,Grobbelaar AO, Objective sensory and functional outcomes at the donor site following endoscopic-assisted sural nerve harvest. Journal of plastic, reconstructive     [PubMed PMID: 28336449]