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Milia


Milia

Article Author:
Patricio Gallardo Avila
Article Editor:
Magda Mendez
Updated:
10/1/2020 11:21:39 PM
For CME on this topic:
Milia CME
PubMed Link:
Milia

Introduction

Milia (singular: milium) are benign and transient dermal cysts of keratine that present as small firm white papules in various numbers most commonly distributed on the face, but they can also be present on other anatomical areas such as the upper trunk, extremities, and genital area (prepuce).

The classification of milia includes primary and secondary. The vast majority of primary milia accounts for congenital milia that occur spontaneously and are present at birth, mainly over the nose, scalp, eyelids, cheeks, gum border (Bohn nodules), and palate (Epstein pearls). Still, there is another percentage of primary milia that may occur in association with certain rare genodermatoses (inherited genetic skin disorders) in children and adults. Meanwhile, secondary milia manifest in association with underlying skin pathology, medications, or skin trauma.[1][2][3][4]

Etiology

Mainly, primary milia are considered to arise from the lower infundibular sebaceous collar of the vellus hair follicles; meanwhile, secondary milia are believed to derive more frequently from the eccrine ducts than from hair follicles, sebaceous ducts or overlying epidermis.[5][6]

The presence of primary milia also is linked with specific inherited genetic skin disorders (genodermatoses), which include oro-facial digital syndrome type 1, congenital hereditary trichodysplasia (Marie-Unna hypotrichosis), Basex-Dupre-Christol syndrome, and some other ectodermal dysplasias. An uncommon presentation of primary milia occurring on an erythematous plaque is known as milia en plaque, which etiology is still not well understood.[1][2][6]

Secondary milia may arise after trauma such as dermabrasion or radiotherapy. They also happen secondary to chronic topical steroid use with underlying atrophy, and nonsteroidal anti-inflammatory drug use. Besides, they may manifest after the clearing of inflammatory skin diseases as sequelae of bullous disorders.[3][6]

Epidemiology

Primary congenital milia are so common that they could be considered as a typical variation, occurring in up to 40% to 50% of healthy full-term neonates. However, milia may be delayed in premature neonates. Primary and secondary milia occur without significant racial or sex differences; only milia en plaque lesions are more common in females. Moreover, milia can affect persons of any age but are most commonly seen in neonates with the congenital form.[2][7][8] 

Histopathology

In 1956, Epstein and Kligman described that "milia are probably the commonest benign tumors of the skin." Histopathologic studies support the notion that milia are not retention cysts, but instead, they represent a simple keratinizing type of benign tumor. Histologically, primary congenital milia look like small cysts of the vellus hair follicles emerging at the level of the sebaceous duct and contain walls of several layers of thick stratified squamous epithelium with a granular cell layer and in the center contain keratinous material. On the other hand, secondary milia lesions present with the same histological characteristics as primary milia lesions. They may also derive from any epithelial structure, including parts of the pilosebaceous apparatus and eccrine glands, such as epidermis, hair follicle, sebaceous duct, or sweat duct.[1][8][9]

History and Physical

Generally, the most common type (primary congenital milia) manifests at birth, but its onset in premature newborns could manifest weeks later. Milia lesions commonly are asymptomatic and will resolve spontaneously during the first months of life. However, clinical information may change according to the milia subtype.

When acquired (secondary milia), usually affect older children and a previous history of trauma or bullous skin disease could be present. This type of milia may persist without treatment. 

Classification of Milia

Primary milia:

  • Congenital
  • Benign primary milia of children and adults
  • Milia en plaque
  • Nodular grouped milia
  • Multiple eruptive milia 
  • Nevus depigmentosus with milia
  • Genodermatosis-associated

Secondary milia:

  • Disease-associated
  • Medication-associated 
  • Trauma-associated 

Physical Examination

Typically, congenital milia lesions occur spontaneously, they consist of small white to yellow papules, less than 3 mm in diameter, and have a smooth dome shape. They could be associated with a faint blue hue in darkly pigmented skin. Milia vary from solitary to multiple grouped lesions. Usually found on the face, characteristically with the nose being involved most of the time.    

Benign acquired milia of children and adults also develop spontaneously. The distribution in children and adults of this type of milia favors the eyelids, cheeks, forehead, and genitalia area.

Lesions of milia en plaque manifest as an erythematous plaque covered with multiple milia. They can reach several centimeters in size. 

Another type includes the acquired and widespread multiple eruptive milia, which appears abruptly over weeks to months. Multiple eruptive milia also in most of the cases occur sporadically. Nonetheless, it may be inherited in autosomal dominant fashion without other evident anomalies or be associated with certain genodermatosis. 

Milia related lesions to genodermatosis have been documented in association with Brooke-Spiegler syndrome, pachyonychia congenita type 2, basal cell nevus syndrome, among others.

Disease-associated milia may occur with blistering skin diseases, such as porphyria cutanea tarda or epidermolysis bullosa.

Milia also happen secondary to chronic topical steroid use with underlying atrophy and nonsteroidal anti-inflammatory drug use.

Secondary traumatic milia most commonly arise after skin burns, skin grafting, dermabrasion, or radiotherapy.[1][2][5]

Evaluation

Milia lesions are diagnosed on clinical findings. Although seldom required, incision and drainage of the keratinous content of milia can corroborate the diagnosis. Additionally, persistent and widely distributed milia may require investigation for other causes of primary and secondary milia, such as an underlying genodermatosis, especially when other clinical findings are present.[5][8]

Treatment / Management

The lesions of congenital milia do not require any particular treatment since these lesions tend to resolve spontaneously. The other forms of primary milia, along with secondary milia may not resolve on its own, and they could be treated with simple surgical interventions such as evacuation, with a tiny incision with a scalpel blade and tangential pressure applied with a comedone extractor or curette. Other treatment options for multiple milia include topical retinoids and electrodesiccation or electrocautery.[5][8]

Differential Diagnosis

The principal differential diagnosis is sebaceous hyperplasia, which manifests as white to yellow grouped papules around the upper lip and nose. Similarly to congenital milia, sebaceous hyperplasia is less frequent in premature newborns. Other differential diagnoses could include comedonal acne, flat warts, milia-like idiopathic calcinosis cutie.[5]

Prognosis

Congenital milia tend to resolve spontaneously without scarring within a couple of weeks, though they may persist for several months, usually disappearing during the first month of life. Acquired milia may continue without treatment.[2][5][10]

Complications

No systemic complications have been documented. Milia are benign and asymptomatic lesions.[5]

Deterrence and Patient Education

Practitioners should educate and inform caregivers about the benign course of milia and the proneness to resolve without scarring spontaneously.

Enhancing Healthcare Team Outcomes

Healthcare workers need to be aware that milia are benign and transient dermal cysts of keratin affecting different areas of the skin, most commonly the face (nose, gums, and palate). Despite that these lesions are often seen in about half of full-term newborns, they receive little attention. 

The natural course of milia is self-limited, and in most of the cases will resolve without scaring at one month of life. However, if present in older children, they could be associated with an underlying inherited skin disorder or to be secondary to skin trauma. Thus in older age groups, these possible etiologies may need to be considered by physicians and nurses based on other historical and clinical findings to improve outcomes. But when in doubt about the diagnosis, the patient should be referred to dermatology. Finally, neonatologists, primary care providers, and nursing staff working in nurseries should provide education to caregivers and their families about this skin condition to improve patient-centered care.[Level V]



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Milia
Milia
Contributed by DermNetNZ

(Click Image to Enlarge)
Milk spots (milia) on the nose of a 1-week old infant.
Milk spots (milia) on the nose of a 1-week old infant.
Contributed by Wikimedia Commons, Serephine (Public Domain)

References

[1] Honda Y,Egawa K,Baba Y,Ono T, Sweat duct milia--immunohistological analysis of structure and three-dimensional reconstruction. Archives of dermatological research. 1996 Mar;     [PubMed PMID: 8967781]
[2] Rutter KJ,Judge MR, Profuse congenital milia in a family. Pediatric dermatology. 2009 Jan-Feb;     [PubMed PMID: 19250409]
[3] Langley RG,Walsh NM,Ross JB, Multiple eruptive milia: report of a case, review of the literature, and a classification. Journal of the American Academy of Dermatology. 1997 Aug;     [PubMed PMID: 9270547]
[4] Rayala BZ,Morrell DS, Common Skin Conditions in Children: Neonatal Skin Lesions. FP essentials. 2017 Feb;     [PubMed PMID: 28196316]
[5] Berk DR,Bayliss SJ, Milia: a review and classification. Journal of the American Academy of Dermatology. 2008 Dec;     [PubMed PMID: 18819726]
[6] Kurokawa I,Kakuno A,Tsubura A, Milia may originate from the outermost layers of the hair bulge of the outer root sheath: A case report. Oncology letters. 2016 Dec;     [PubMed PMID: 28105227]
[7] Haveri FT,Inamadar AC, A cross-sectional prospective study of cutaneous lesions in newborn. ISRN dermatology. 2014;     [PubMed PMID: 24575304]
[8] Kutlubay Z,Tanakol A,Engýn B,Onel C,Sýmsek E,Serdaroglu S,Tuzun Y,Yilmaz E,Eren B, Newborn Skin: Common Skin Problems. Maedica. 2017 Jan;     [PubMed PMID: 28878836]
[9] EPSTEIN W,KLIGMAN AM, The pathogenesis of milia and benign tumors of the skin. The Journal of investigative dermatology. 1956 Jan;     [PubMed PMID: 13295633]
[10] Nakai N,Okuzawa Y,Katoh N,Kishimoto S, Persistent congenital milia involving the skin of the whole body in an infant with trisomy 13 syndrome. Pediatric dermatology. 2010 Nov-Dec;     [PubMed PMID: 21510019]