Leukotriene Receptor Antagonists

Continuing Education Activity

Montelukast and zafirlukast are cysteinyl leukotriene receptor antagonists indicated for the prevention and treatment of chronic asthma. This activity will highlight the mechanism of action, adverse event profile, and monitoring pertinent for members of the interprofessional team in the management of patients with asthma and related conditions with leukotriene receptor antagonists.


  • Explain the mechanism of action and administration of leukotriene receptor antagonists.
  • Describe the adverse effects and contraindications of leukotriene receptor antagonists.
  • Review the appropriate monitoring and toxicity of leukotriene receptor antagonists.
  • Summarize interprofessional team strategies for improving care coordination and communication to advance the treatment of asthma with leukotriene receptor antagonists and improve outcomes.


Montelukast and zafirlukast are cysteinyl leukotriene receptor antagonists.[1] Leukotrienes are eicosanoid inflammatory mediators derived from arachidonic acid. Montelukast's indications are the prophylaxis and chronic treatment of asthma, the prevention of exercise-induced bronchospasm, and the relief of symptoms of allergic rhinitis.[2][3]

Montelukast monotherapy is not recommended for first-line therapy for allergic rhinitis.[4] Instead, monotherapy with an intranasal glucocorticoid is a strong recommendation in the initial treatment of patients with moderate/severe seasonal allergic rhinitis who are 12 years of age or older and not treated previously.[5] The role of montelukast in an effective treatment for eczema remains inconclusive.[6]

Parents of asthmatic children prefer montelukast because the once-a-day oral dosage is more convenient than inhaler use. It also avoids the concerns regarding the side effects of long-term use of corticosteroids, such as growth retardation and metabolic abnormalities.

Zafirlukast indications include the prophylaxis and chronic treatment of asthma in children five years and older and adults. It is used off-label for allergic rhinitis and the prophylaxis of exercise-induced bronchospasm.

The first-line therapy for the prophylaxis of exercise-induced bronchospasm is inhaled short-acting beta-agonist such as albuterol. Daily use of inhaled corticosteroid or leukotriene receptor antagonists, such as montelukast and zafirlukast, is recommended in patients with exercise-induced bronchospasm who inhaled preventative short-acting beta-agonist but continue to have symptoms or who develop tolerance to continued usage of short-acting beta-agonist.[7]

Both montelukast and zafirlukast have no role as rescue medication during an acute asthmatic attack.[8] Instead, inhaled beta-agonist induces immediate bronchodilation.

Mechanism of Action

The main indication for leukotriene receptor antagonists is in the treatment of chronic asthma. Leukotrienes are synthesized from arachidonic acid by the action of 5-lipoxygenase in many inflammatory cells in the airways.[9] Arachidonic acid is released from cell membrane phospholipids mainly by phospholipase A2.[10] Cyclooxygenase pathway produces thromboxane and prostaglandins from arachidonic acid. Corticosteroids inhibit phospholipase A2 and subsequent synthesis of eicosanoid inflammatory mediators, including both prostaglandins and leukotrienes. Non-steroidal anti-inflammatory drugs such as aspirin inhibit cyclooxygenases. Zileuton inhibits 5-Lipoxygenase.

There are two groups of leukotrienes: one with and the other without amino acid moieties.[1] Leukotriene B4 carries hydroxyl moiety only and binds to BLT receptors. The signaling pathway via G protein-coupled BLT receptor activation produces potent chemotaxis response. Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) have amino acid moiety and bind to cysteinyl leukotriene receptors (CysLT1 and CysLT2). Bronchoconstriction, vascular permeability, eosinophil recruitment, and chronic inflammation are mediated through the G protein-coupled activation of cysteinyl leukotriene receptors. Montelukast and zafirlukast are antagonists to cysteinyl leukotriene CysLT1 receptors but not to CysLT2 receptors. Research has shown that eosinophils are the main source of cysteinyl leukotrienes, and cysteinyl leukotrienes are very important in eosinophil recruitment.[11] Earlier studies have shown that cysteinyl leukotrienes also play an important role in airway remodeling in chronic asthma.[12]

Asthma is the most common chronic lung disease characterized by reversible bronchoconstriction, inflammation, and airway remodeling that results in hyperresponsiveness. Sympathomimetic agents such as beta-adrenergic receptor agonists are the therapeutic choice for treatment for acute bronchoconstriction. They activate beta two adrenergic receptors and relax airway smooth muscle cells. Short-acting beta2-selective agonists include albuterol, levalbuterol, terbutaline, metaproterenol, and pirbuterol. They sustain bronchodilation for 3-4 hours. Long-acting beta2-selective agonists with 12-hour durations of action include salmeterol and formoterol. Ultra-long-acting beta-agonists such as indacaterol, olodaterol, vilanterol, and patients should take bambuterol only once a day. Because beta-agonists do not inhibit inflammatory responses, they do not have a role as monotherapy for control of persistent asthma and are frequently a second agent added to inhaled corticosteroid.[13]

Based on the inflammatory mechanism of asthma, several pharmacological agents with different modes of action have undergone development to treat this endotype of asthma. Exposure to allergen stimulates the synthesis of IgE driven by CD4+ T helper type 2 cells. The IgE antibodies bind to their receptors on the tissue mast cells and blood basophils.[14] On re-exposure to an allergen, allergen cross-links the IgE antibodies on the immune cell surface. It triggers the release of preformed mediators of anaphylaxis and synthesis of inflammatory mediators. Cromolyn or nedocromil may prevent mast cell degranulation. However, these drugs are not commonly used in asthma treatment nowadays because they are less effective than inhaled corticosteroids. Histamine, tryptase, and arachidonic acid metabolites such as leukotrienes C4 and D4, and prostaglandin D2 are released and cause acute smooth muscle contraction and increased vascular permeability. Three to six hours later, more sustained bronchoconstriction occurs in the late asthmatic response. There are suggestions that the cytokines produced by type 2 immune response mediate late asthmatic response.[15]

Advances in the understanding of molecular heterogeneity of asthma have revealed the importance of type 2 immune response mediated by T helper type 2 cells in the pathology of eosinophilic asthma.[16] Omalizumab is a monoclonal antibody that can reduce the amount of circulating IgE. IL-4, IL-5, and IL-13 mediate type 2 immune responses. Anti-IL-5 antibody mepolizumab minimizes the number and activity of eosinophils in the airway mucosa. Dupilumab is an anti-IL-4 receptor antibody.


Montelukast administration is via the oral route, without regard to food or meals. It should be taken a single dose in the evening in patients with asthma, and both asthma and allergic rhinitis. For the treatment of allergic rhinitis, administration can be either morning or evening. For the prevention of exercise-induced asthma, it should be taken at least two hours before exercise. Patients should not take another dose within 24 hours.

Zafirlukast is administered orally. It should be taken 2 hours after or 1 hour before meals because food decreases bioavailability by 40%.

Adverse Effects

Montelukast is relatively well tolerated generally safe.[17] The most commonly observed side effects in patients aged 15 years and over were headaches, influenza infection, abdominal pain, cough, and dyspepsia. In children, diarrhea, nausea, laryngitis, pharyngitis, sinusitis, otitis, and viral infection. Neuropsychiatric disorders, including depression, aggression, suicidal ideation, insomnia, anxiety, and nightmares, may occur.[18] Allergic granulomatous angiitis (Churg-Strauss syndrome) may also correlate with the use of montelukast, although there is not yet an established causal relationship.[19][20] There are some reports of serious adverse events due to angioedema, hypersensitivity, fatigue, confusional state, abnormal dreams, epilepsy, aggression, immune system disorder, hemorrhage, excoriation, eosinophil count increase, pain in extremity, and abdominal pain.[18] In an animal study, it did not produce teratogenic effects at doses much higher than the maximum daily dose in humans.[17]

Zafirlukast is generally well tolerated, and associated adverse events are minimal.[21] Headache, upper respiratory tract infection, gastrointestinal disturbances such as nausea, vomiting, dyspepsia, abdominal pain, and diarrhea, and malaise are common adverse effects.[21] Rarely, the elevation of liver enzymes, acute hepatitis, and hyperbilirubinemia has been linked to zafirlukast.[22][23]


Both montelukast and zafirlukast are contraindicated in person who has hypersensitivity to the drug or any component of their formulation. Contraindications to zafirlukast also include patients with hepatic impairment.


Depression, aggression, and other behavioral changes have correlations with the leukotriene receptor antagonists. Careful monitoring is necessary for patients treated with leukotriene receptor antagonists.

Zafirlukast may cause severe but rare acute liver damage. It is a major substrate of cytochrome P450 CYP2C9 enzyme. Patients who are receiving concomitant therapy with drugs such as alpelisib, dabrafenib, enzalutamide, erythromycin, loxapine, lumacaftor, rifapentine, terfenadine, and warfarin require monitoring for potential drug interactions.[24]


Both montelukast and zafirlukast have a wide margin of safety. Patients who took an overdose had no adverse symptoms, an uneventful course of recovery, or a rash and upset stomach.[25][26]

When overdosed, remove unabsorbed drugs using active charcoal and institute supportive therapy, if needed.

Enhancing Healthcare Team Outcomes

Several adverse drug reactions were reported to the Netherlands pharmacovigilance center Lareb and the WHO global individual case safety report database. The most common adverse effect in the whole population was depression, and in children under the age of 19 years was aggression.[18] Suicidal ideation, abnormal behavior, nightmares, headaches, insomnia, and anxiety have been reported in patients treated with montelukast. Nightmares may frighten children. Aggression and abnormal behavior of children may cause concerns from their parents and teachers. Insomnia in adults may impact the safety of the patients and others. The healthcare team should educate their patients or parents and monitor the incidence of adverse drug effects.

Asthma is a chronic lung disease. Even in patients with a well-established medication regimen, acute asthma exacerbations may occur. Understanding the risk factors for exacerbation prone asthma is critical for the prevention of potentially fatal acute asthma attack.[27][28]

Both African Americans and Hispanics have a higher incidence of exacerbations. Poor compliance with medication due to patient’s poor access to healthcare and inadequate education and knowledge about the disease put the patients in great risk to acute exacerbations. Other potentially modifiable risk factors include uncontrolled allergies, upper respiratory viral infections, obesity, smoking, and gastroesophageal reflux disease.[29][30][31][32] Multidisciplinary approaches by the healthcare team may reduce acute asthma attack by taking control of these risk factors.

Article Details

Article Author

Jaehwa Choi

Article Editor:

Chaudhary Ehtsham Azmat


5/5/2021 11:55:29 AM



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