Anatomy, Head and Neck, Eye Lacrimal Gland

The lacrimal gland is a bilobed, tear-shaped gland with the primary function of secreting the aqueous portion of the tear film, thereby maintaining the ocular surface. It is primarily located in the anterior, superotemporal orbit within the lacrimal fossa of the frontal bone. The tendon of levator palpebrae superioris bisects the lacrimal gland, giving rise to 2 lobes: a smaller palpebral component found continuous with the inner eyelid, and a larger orbital component. Its histological composition is mixed serous and mucinous acini, myoepithelial cells, and small interconnecting ductules.

The lacrimal gland plays a prominent role in the formation of the tear film, a trilaminar structure that performs the following functions: 1) provides a protective barrier for the ocular surface; 2) provides a smooth optical surface at the air-cornea interface; 3) functions as a medium for removal of debris.  The tear film is composed of an inner mucin layer that interfaces with the corneal surface, a middle aqueous layer, and an outer lipid layer. Serous acini are the predominant tissue found in the lacrimal gland, secreting the aqueous component, which forms most of the tear film fluid volume. The corneal surface is hydrophilic in composition, necessitating an additional component, soluble mucin, to bind to its hydrophobic surface and establish a hydrophilic character, allowing uniform adherence of the aqueous layer to the corneal surface. Mucin is secreted principally by the conjunctival goblet cells and the stratified squamous cells of the conjunctival and corneal epithelia. The contribution by the lacrimal glands of Henle and Manz is minimal.

Within the lacrimal gland, interlobular ducts connect the orbital lobe with the palpebral lobe. Tear fluid is secreted in the upper conjunctival fornix from both lobes via excretory ducts, and between 2 and 5 ducts from the palpebral lobe secrete fluid into the lower conjunctival fornix.[1] 

Tear fluid originating from the lacrimal gland and other tissue drains into the nose via the nasolacrimal duct system. All tear fluid drains initially drains from the eye through the lacrimal puncti, followed by the lacrimal tubular canaliculi, nasolacrimal sac, nasolacrimal duct, the valve of Hasner, and finally into the nose.[2]

In addition to its contribution to the aqueous portion of the tear film, the lacrimal gland has adaptive immune function through myoepithelial cell secretion of IgA and IgG antibodies. It is associated with mucosa-associated lymphoid tissue (MALT) and is susceptible to autoimmune-inflicted damage commonly seen to affect MALT.

The lacrimal gland embryologically derives from immune, epithelial, and mesenchymal cell lineages.[3] As with most tubular organs, the development of the lacrimal gland involves a series of interactions between epithelial and mesenchymal tissue that is not entirely understood. The morphogenetic protein BMP7 is expressed in the developing gland and facilitates branching into terminal ductule lobular units via signaling directed to mesenchymal tissue.[4]

The arterial blood supply of the lacrimal gland is the lacrimal artery, a branch of the ophthalmic artery. Venous blood returns from the lacrimal gland via the lacrimal vein, which feeds into the superior ophthalmic vein that traverses the cavernous sinus. Lymphatic draining of the orbit and its associated structures is still an area of ongoing research and debate.[5]

The secretion of aqueous by the lacrimal gland is a response to parasympathetic and sympathetic stimulation. The gland receives parasympathetic innervation via fibers that originate in the lacrimatory nucleus of the facial nerve in the pons. Presynaptic parasympathetic fibers travel with the facial nerve to the geniculate ganglion, where they diverge, forming the greater petrosal nerve. The greater petrosal nerve passes through the foramen lacerum and is joined by the deep petrosal nerve (which contains sympathetic fibers from the superior cervical ganglion), forming the nerve of the pterygoid canal. This nerve then synapses on the pterygopalatine ganglion. Postsynaptic parasympathetic fibers leaving the pterygopalatine ganglion form the zygomatic and zygomaticotemporal nerves. These fibers travel with the lacrimal branch of the maxillary nerve to reach the lacrimal gland. Innervation of the gland by these parasympathetic fibers is either direct, indirect via communication with the lacrimal nerve, or both. In the majority of cases, the zygomaticotemporal nerve directly enters the lacrimal gland.[6]

Sympathetic innervation of the lacrimal gland originates in the superior cervical ganglion. These postsynaptic fibers travel with the internal carotid artery before joining the greater petrosal nerve, forming the nerve of the pterygoid canal. As this nerve reaches the pterygopalatine ganglion, sympathetic fibers do not synapse but continue to travel with the parasympathetic fibers that reach the lacrimal gland.

Sensory innervation of the lacrimal gland is via the lacrimal nerve, a branch of the ophthalmic nerve.