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The gastrointestinal (GI) tract is the most frequent site in the body for several types of abnormal blood vessels, which represent irregularities in the normal form of the affected arteries, veins, or capillaries. Vascular abnormalities can be benign or malignant such as hemangiomas or angiosarcomas, respectively. Also, they can be congenital, such as hereditary hemorrhagic telangiectasia or mostly acquired, such as angiodysplasia.[1] Angiodysplasia is an abnormal, tortuous, dilated small blood vessel in the mucosal and submucosal layers of the GI tract. The abnormal vessels consist of endothelium with scant or no smooth muscle.[2] Angiodysplasia is the most frequent etiology of small bowel bleeding or formerly called obscure gastrointestinal bleeding (OGIB) in patients more than 60 years of age.[3] Angiodysplasia is not related to any hereditary, skin, or systemic disease and can affect any part of the GI tract.[4]
Although the exact etiology of angiodysplasia is unclear, many ideas appear in the literature, including age-related degeneration of small blood vessels and also cardiovascular and pulmonary disease, which may cause hypoperfusion of microvessels leading to ischemic necrosis of abnormal vascular lesions.[4] Angiodysplasia can be related to aortic stenosis.[5] Another reported the cause of angiodysplasia was the mucosal hypoperfusion associated with cardiac disease.[6] In von Willebrand disease (VWD), there has been bleeding reported from upper and lower GI angiodysplasia lesions.[7]
In the general population, the most common vascular abnormality in the GI tract is angiodysplasia, which mainly occurs in patients over 60 years of age.[8][9] The prevalence of angiodysplasia increases with age. It may have no symptoms or present with GI bleeding.[10] There are reports of non-variceal upper GI bleeding caused by angiodysplasia in approximately 5% to 10% of patients.[11] Small bowel angiodysplasia is the most common cause of obscure GI bleeding (OGIB) in patients older than 50 years old. In contrast, small bowel tumors are the common cause in patients under 50 years old with OGIB[3][12]. The most common site of angiodysplasia in the GI tract is the colon.[13] Angiodysplasia has been reported to be associated more with some conditions in literature such as end-stage renal disease (ESRD), Von Willebrand disease, left ventricular assist device (LVAD), and aortic stenosis (Heyde syndrome).
End-stage renal disease - Peptic ulcer disease remains the most common cause of GI bleeding in end-stage renal disease patients. Still, angiodysplasia is another sizeable cause of both upper and lower GI bleeding in these patients and accounts for almost 20% to 30%, respectively. According to one report, one-half of patients with recurrent bleeding in chronic renal failure were because of angiodysplasia.[14][15]
Aortic stenosis (Heyde syndrome) - Heyde in 1958 first suggested association of unknown cause of GI bleeding, which was later attributed to angiodysplasia and aortic stenosis. The association is still subject to debate, and there are mixed small case-control and retrospective studies both in favor and against the association. There have also been reports of cessation of recurrent GI bleed on long term follow up after aortic valve replacement.[16][17][18]
Systemic sclerosis (SSc) - Gastric antral vascular ectasia (GAVE or watermelon stomach) is vascular malformation of gastric antral mucosa sometimes is considered a variant of angiodysplasia under the broad spectrum of vascular anomalies however many authors consider it as a systemic disease such as systemic sclerosis-related vascular ectasia. The prevalence of GAVE has been estimated at 5.7% in patients with SSc based on one large retrospective disease[19].
There is no causal association found yet and the association between these diseases, and angiodysplasia could be secondary to more endoscopic investigation related bias because patients with these conditions are more prone to have gastrointestinal bleeding secondary to underlying coagulopathy such as uremic platelet dysfunction in ESRD and acquired Von Willebrand factor deficiency in aortic valve stenosis and left ventricular assist device (LVAD).[20][20][21][22][23]
Although the mechanism of angiodysplasia is not clear, the hypothesis is that as a result of increased contractility at the level of muscular propria, submucosal veins may become obstructed. Chronic obstruction of these vessels may result in age-related angiodysplasia lesions. Congestion of the capillaries and precapillary sphincter failure, lead to the formation of arteriovenous collaterals.[24]
Angiogenesis is an important mechanism of the development of new vessels, which increases vascularity in the case of hypoxia or ischemia. In hypoxia, the expression of angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor increase in angiodysplasia. These factors are significant in the development of angiodysplasia and changing the risk of bleeding.[25][26]
In endothelial cells, inhibition of von Willebrand factor (VWF) expression is shown to increase proliferation by VEGF and angiogenesis showing a correlation between hemostasis and angiogenesis, which is useful in the treatment of patients with angiodysplasia and VWD.[27]
Although usually readily apparent on colonoscopy and angiography, angiodysplasia is often extremely difficult to detect on the gross examination of a resected specimen without the use of specific injection techniques. As a result of vascular injection studies of resected colons, the determination was that angiodysplasia develops as a result of intermittent partial obstruction of small veins that drain the colonic mucosa and submucosa as they course through the muscularis propria. Over time, obstruction of the penetrating veins of the muscularis propria leads to dilation and tortuosity of the submucosal veins and, consequently, the venules and capillaries that drain them.
Angiodysplasias are often challenging to diagnose in pathologic specimens. In resected specimens examined while fresh, one may visualize only a small focus of enhanced vascular markings and erythema, and even these subtle signs may be absent. In specimens examined after formalin fixation, the lesions are usually not visible on the mucosal surface. If a vascular lesion is detected, the histologic examination typically reveals a discrete cluster of dilated, tortuous veins and venules within the submucosa, some associated with dilated capillaries in the overlying mucosa as well.[28]
Patients with angiodysplasia may be asymptomatic or present with mild to moderate occult lower GI bleeding without abdominal pain. History should include all the same elements as it would in the evaluation of upper and lower GI bleeding. Patients may present with occult blood in stool and iron deficiency anemia. Physical examination in a hemodynamic patient may show symptoms and signs of anemia. A systolic ejection murmur during the cardiac examination may raise suspicion for underlying aortic stenosis. Angiodysplasia lesions may be found incidentally in endoscopy for other reasons. Orthostasis or hypotension may rarely occur in acute and heavy bleeding. Although bleeding stops spontaneously in most patients, it may recur. Angiodysplasia-related GI bleeding can happen anywhere in the GI tract but more frequently seen in the cecum, rectosigmoid area, the rest of the colon, small intestine, and stomach in descending order.[29]
Angiodysplasia is usually diagnosed as an incidental finding during colonoscopy for colorectal cancer screening exams or when evaluating the patient for acute or chronic blood loss related anemia. The initial diagnostic modality depends on the characteristics of bleeding and suspicion for the location of the source. Slow bleeding from the stomach or small bowel may present as melena, while a colonic origin may present as fresh red blood per rectum. The clinician should be mindful that sometimes heavy bleeding from the upper GI tract may also show fresh blood per rectum. Evaluation of a patient should include vitals assessment to ensure hemodynamic stability. Initial investigation of complete blood count, liver function test, coagulation studies, and renal function test is usually required to know the severity of anemia and diagnose any underlying medical condition associated with bleeding such as end-stage renal disease, congenital or acquired coagulation disorders such as in cirrhosis. Because angiodysplasia is omnipresent throughout the GI tract, a combination of studies with endoscopy may be necessary.
Upper GI endoscopy and colonoscopy are common initial diagnostic tools. Angiodysplasia on direct visualization from endoscopy or colonoscopy looks like 5 to 10 mm flat cherry-red fern-like projecting vessels originating from a central artery.[30] Estimates of the sensitivity of colonoscopy to diagnose angiodysplasia are at around 80 percent and a positive predictive value of about 90%.[31]
Small bowel angiodysplasia as a source of obscure GI bleeding may require further evaluation with wireless video capsule endoscopy or deep bowel enteroscopy (single or double-balloon enteroscopy) if the initial workup is negative.
Radionuclide scanning images are the most sensitive radiologic diagnostic tool during active bleeding, which can detect bleeding up to 0.1 to 0.5 ml/min. It is done with two types of nuclear scans 99m Tc pertechnetate autologous red blood cell and technetium sulfur colloid. Technetium red cell scintigraphy is now commonly used because of its longer half-life allow to obtain imaging at definite time interval up to 24 hours after initial injection increasing its yield to diagnose intermittent active bleeding compared to technetium sulfur colloid test.[32] The biggest drawback of radionuclide scanning is that it generally shows active bleeding extravasation on a localized area of general abdominal imaging, which may not correlate to the specific site of bleeding because of the peristaltic nature of intestine.
CT angiography and magnetic resonance angiography are also useful investigative tools to investigate further if the conventional investigation does not show bleeding sources. Helical CT angiography sensitivity and specificity are 70 and 100 percent, respectively. However, it yields more results during active bleeding, with a minimum rate of bleeding is 0.3 to 0.5 ml/min.[33]
Angiography is usually necessary for actively bleeding unstable hemodynamically patients or patients in whom the active source of bleeding remains unidentified with conventional diagnostic methods. Angiography requires 0.5 to 1 ml/min blood loss to diagnose the active source of bleeding and also provides the benefit of therapeutic intervention at the same time.[34]
Intraoperative enteroscopy is useful when both endoscopic and radiological investigation fails to detect the source of bleeding. It is done by inserting an endoscopy by oral, rectal, or enterotomy route during surgery. The diagnostic yield is estimated to be 60 to 88 percent. Intraoperative enteroscopy is rarely used and only done when there is no source identified in an active bleeding patient. Complication includes perforation, serosal, mesentery or vessel tears, azotemia, and prolonged ileus.[35][36]
Angiodysplasia is more commonly diagnosed as an incidental finding for endoscopy for different reasons and can divide into incidental angiodysplasia, nonbleeding angiodysplasia in a patient with GI bleeding, and an actively bleeding angiodysplasia with GI bleeding. Clinicians should base treatment decisions on these factors.
Incidental angiodysplasia- Incidental angiodysplasia should not have treatment if there is no history of GI bleeding or unexplained iron deficiency anemia. The future risk of incidental angiodysplasia-related bleeding is unknown, and the recommendation is based solely on expert opinions.
Nonbleeding angiodysplasia in a patient with GI bleeding - In these patients, angiodysplasia should have treatment, which again has its basis on expert opinions.
Actively bleeding angiodysplasia- In most patient’s management should follow a similar path as in managing upper and lower GI bleeding for other reasons, which is hemodynamic resuscitation, frequent complete blood count monitoring, and blood transfusion if needed. Treatment decisions should be dependent on hemodynamic stability and whether the patient is actively bleeding or not.
Hemodynamically unstable patient - In an unstable patient with active bleeding intravenous fluid resuscitation should be started immediately. If the patient is obtunded with a thready pulse, hypoxic, having active hematemesis, and unable to protect the airway, then they need to be intubated and admitted in the intensive care unit for frequent CBC monitoring and blood transfusion as required. An endoscopy or colonoscopy should be done if possible, but it may not be possible if the patient is actively bleeding. In that case, surgery or radiology intervention with angiography is usually required.
Hemodynamically stable patient - In patients with stable vitals, an endoscopy or colonoscopy should be done within 24 hours based on characteristics of bleeding. If the test reveals no identified source, then the next diagnostic modality is chosen on the fact whether the bleeding is active or not.
Endoscopy or colonoscopy - If angiodysplasia is present on endoscopy or colonoscopy then different techniques can be used to treat angiodysplasia which is as follows
Endoscopy with push enteroscopy is used to investigate and treat with endoscopic intervention in OGIB.
Angiography- Usually done in patients with active bleeding who have failed other treatment mentioned above, patients who are poor surgical candidates, and to localize bleeding sites as a preoperative investigation before surgical resection. The therapeutic intervention involves either temporary absorbable gelatin sponge, local infusion of vasopressin, or permanent such embolization with micro-coils, particles, or glue. Major complication includes bowel ischemia or infarction along with complication of arteriography itself. The initial success rate of achieving hemostasis with embolization in lower GI bleed is 95% and 64% to 89% in upper GI bleeding.[42][43] Estimates of lower GI bleed embolization rebleeding rates are 22% to 48%.[44][45]
Surgery - Surgical resection is required eventually in patients with heavy active bleeding requiring multiple blood unit transfusion with failed all other measures described above.[46] Rebleeding after surgery could be secondary to inadequate resection or missed lesion. Preoperative workup with push enteroscopy, intraoperative enteroscopy, and angiography can better localize the bleeding site to reduce rebleeding rate. Endoscopy or colonoscopy also can be done preoperatively and can inject dye or put an endoclip to demarcate the lesion for better localization during surgery. Intraoperative enteroscopy can also help in localization of the unidentified lesions. Aortic valve replacement in a patient with associated aortic stenosis may improve angiodysplasia-related bleeding.[16]
Angiogenesis inhibitors - Thalidomide and bevacizumab have been described with success in the treatment of gastrointestinal vascular malformation, including angiodysplasia.[25][26][47] In one clinical trial, an effective response rate, which was described GI bleeding cessation by over 50% by the end of the year, was 71.6% in the thalidomide treated group compared to the control group 3.7%.[48] Even though thalidomide has shown some promise in refractory angiodysplasia-related GI bleeding and transfusion-dependent patients, thalidomide use requires caution in this patient population because of extensive side effects, including teratogenicity. Another angiogenesis inhibitor bevacizumab is a human monoclonal antibody again vascular endothelial growth factor and has been used in some case reports and series for the treatment of refractory GI bleeding related to angiodysplasia but because of the paucity of data should be used as last resort.[47]
Hormone therapy - Few studies have evaluated treatment with estrogen with or without progesterone in chronic obscure GI bleeding.[49] However, other studies, including a randomized controlled trial, did not show any benefit of hormonal therapy in the prevention of angiodysplasia-related GI bleeding.[50]
Octreotide – Octreotide seems to be effective in the treatment of refractory angiodysplasia related GI bleeding, as mentioned in some case series and meta-analysis. Octreotide with twice-daily subcutaneous injections with dose 50 to 100 mcg and long-acting form, octreotide-LAR, which is given intramuscularly once a month is an option. The studies which evaluated octreotide showed 73 to 76% of patients showed response in terms of bleeding events, transfusion requirement, and mean hemoglobin.[51] [52][53][54] Based on the results of these studies, octreotide may be an option in patients with refractory angiodysplasia-related bleeding.
Symptomatic angiodysplasia usually presents with symptoms similar to upper and lower GI bleeding, which is either unexplained iron deficiency anemia or GI bleeding. Differential diagnosis includes common causes of both upper and lower GI bleeding.
Patients with angiodysplasia have a good prognosis because the bleeding subsides automatically in most cases. Patients with ten or more angiodysplasia lesions or lesions larger than 10 mm, may have a worse prognosis, lower hemoglobin level, and require more blood transfusions.[56]
Chronic occult bleeding and iron deficiency anemia is the most common complication and presenting symptoms of symptomatic angiodysplasia. Rarely symptomatic angiodysplasia may present as massive bleeding and can cause hemodynamic instability.
Gastroenterologist consultation is necessary for patients with symptomatic angiodysplasia for confirmation of diagnosis and further treatment with a combination of different endoscopic methods. Patients with symptomatic angiodysplasia with an unconfirmed source of bleeding after initial investigations may require an interventional radiology consultation for angiography for diagnosis as well as the opportunity for treatment. Cases with uncontrolled bleeding after attempts to control it fails with all other intervention will require surgery.
Patient reassurance is recommended in most cases of incidental angiodysplasia since it is usually asymptomatic. The decision for therapy by endoscopy is usually based on clinical presentation and the presence of GI bleeding or unexplained iron deficiency anemia.
The majority of patients with bleeding angiodysplasia present to the emergency department, and hence the nursing staff and triage need to be aware of the management of these patients. Because the diagnosis is not simple, numerous specialists may be involved, along with other healthcare providers, as part of the interprofessional team approach to care. For those who are unstable, resuscitation is vital. Once stable, imaging studies are required to locate the angiodysplasia for more definitive treatment. Acutely bleeding patients must be monitored in an intensive care setting and be aware of the potential complications.
When choosing medical treatment, the specialist should work closely with a board-certified pharmacotherapy pharmacist to optimize drug selection and dosing. A gastroenterology specialty nurse can also verify patient compliance, provide patient counsel, and evaluate therapeutic effectiveness, irrespective of the treatment path chosen. Close communication and collaboration between specialists and all members of the interprofessional team are vital for improving outcomes; this includes ED physicians, specialists, pharmacists, and nursing. [Level 5]
A recent case-control study with 270 patients diagnosed between 2010 and 2015 with angiodysplasia and 5594 controls demonstrated that the risk factors for incidental angiodysplasia are anticoagulants, autoimmune disease, chronic obstructive pulmonary disease, male gender, and thyroid dysfunction. They showed that risk factors related to symptomatic angiodysplasia are advanced age, diabetes mellitus, hyperlipidemia, and valvular heart disease. The risk factors for symptomatic angiodysplasia are different and more significant than incidental angiodysplasia, which may help in a proper treatment plan of a patient with angiodysplasia.[57]
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