Bacterial Pneumonia (Nursing)


Learning Outcome

  1. Recall the signs and symptoms of bacterial pneumonia
  2. Describe the management of bacterial pneumonia
  3. Summarize the nursing diagnosis of pneumonia
  4. Discuss the prevention of bacterial pneumonia

Introduction

The word "pneumonia" originates from the ancient Greek word "pneumon" which means "lung," so the word "penumonia" becomes "lung disease." Medically it is an inflammation of one or both lung's parenchyma that is more often but not always caused by infections. The many causes of pneumonia include bacteria, viruses, fungi, and parasites. This article is about bacterial causes of pneumonia as it is the major cause of mortality and morbidity by pneumonia. According to the new classification of pneumonia, there are four categories: community-acquired (CAP), hospital-acquired (HAP), healthcare-associated (HCAP) and ventilator-associated pneumonia (VAP). [1][2][3]

Types of Bacterial Pneumonia

  • CAP: The acute infection of lung tissue in a patient who has acquired it from the community.
  • HAP: The acute infection of lung tissue that develops 48 hours or longer after the hospitalization of a non-intubated patient.
  • VAP: A type of nosocomial infection of lung tissue that usually develops 48 hours or longer after intubation for mechanical ventilation.
  • HCAP: The acute infection of lung tissue acquired from healthcare facilities such as nursing homes, dialysis centres, and outpatient clinics or a patient with hospitalization within the past 3 months (previously included in HAP but becomes a separate category after some cases presenting as outpatients with pneumonia have been found to be infected with multidrug-resistant (MDR) pathogens previously associated with HAP).

Some articles include both HAP and VAP under the category of HCAP, so defining HCAP is problematic and controversial.

Nursing Diagnosis

  • Chills
  • Chest discomfort
  • Cough
  • Nausea
  • Dyspnea
  • Fatigue
  • Fever
  • Altered mental status

Causes

Etiology of community-acquired pneumonia is an extensive list of agents that include bacteria, viruses, fungi, and parasites, but this article is about bacterial pneumonia and its causes. Bacteria have classically been categorized into two divisions on the basis of etiology, "typical" and "atypical" organisms. Typical organisms can be cultured on standard media or seen on Gram stain, but "atypical" organisms do not have such properties. [4]

  • Typical pneumonia refers to pneumonia caused by Streptococcus  pneumoniae, Haemophilus influenzae, S. aureus, Group A streptococci, Moraxella catarrhalis, anaerobes and aerobic gram-negative bacteria.
  • Atypical pneumonia is mostly caused by Legionella spp, Mycoplasma pneumoniae, Chlamydia pneumoniae, and C. psittaci.

The most common causes of community-acquired pneumonia (CAP) is S. pneumoniae followed by Klebsiella pneumoniae, Haemophilus influenzae, and Pseudomonas aeruginosa. The most common causes of HCAP and HAP are MRSA (methicillin-resistant Staphylococcus aureus) and Pseudomonas aeruginosa respectively. The causative agents of VAP include both multi-drug resistant (MDR) agents (e.g., S. pneumoniae, other Strep spp, H. influenzae and MSSA) and non-MDR (e.g., P. aeruginosa, methicillin-resistant Staphylococcus aureus, Acinetobacter spp. and antibiotic-resistant Enterobacteriaceae) bacterial pathogens.

Risk Factors

The incidence of CAP in the United States is more than 5 million per year; 80% of these new cases are treated as outpatients with the mortality rate of less than 1%, and 20% are treated as inpatients with the mortality rate of 12% to 40%. The incidence of CAP varies among different genders; for example, it is more common in males and African Americans than females and other Americans. The incidence rates are higher at extremes of age distribution range; the adult rate is usually 5.15 to 7.06 cases per 1000 persons per year, but in the population of age less than 4 years and greater than 60 years, the rate is more than 12 cases per 1000 persons. In 2005, influenza and pneumonia combined was the eighth most common cause of death in the United States and the seventh Most common cause of death in Canada. The mortality rate also is variable among different regions at  7.3% for the United States and Canada, 9.1% for Europe, and 13.3% for Latin America.[5][6]

Assessment

The history findings of bacterial pneumonia may vary from indolent to fulminant. Clinical manifestation includes both constitutional findings and findings due to damage to the lung and related tissue. The following are major history findings:

  • Fever with tachycardia and/or chills and sweats.
  • The cough may be either nonproductive or productive with mucoid, purulent or blood-tinged sputum.
  • Pleuritic chest pain, if the pleura is involved.
  • Shortness of breath with normal daily routine work.
  • Other symptoms include fatigue, headache, myalgia, and arthralgia.

Physical findings also vary from patient to patient and mainly depend on the severity of lung consolidation and existence or nonexistence of pleural effusion. The following are major clinical findings:

  • Increased respiratory rate.
  • Percussion sounds vary from flat to dull.
  • Tactile fremitus.
  • Crackles, rales, and bronchial breath sounds are heard on auscultation.

Confusion manifests earlier in older patients. A critically ill patient may present with sepsis or multi-organ failure.

Evaluation

The approach to evaluate and diagnose pneumonia depends on different modalities but primarily it is like a tripod stand which has 3 legs which are summed up as:

  • Clinical Evaluation: It includes taking a careful patient history and performing a thorough physical examination to judge the clinical signs and symptoms mentioned above.
  • Laboratory Evaluation: This includes lab values such as complete blood count with differentials, inflammatory biomarkers like ESR and C-reactive protein, blood cultures, sputum analysis or Gram staining and/or urine antigen testing or polymerase chain reaction for nucleic acid detection of certain bacteria.
  • Radiological Evaluation:  It includes chest x-ray as an initial imaging test and the finding of pulmonary infiltrates on plain film is considered as a gold standard for diagnosis when the lab and clinical features are supportive.[7][2]

Medical Management

In all patients with bacterial pneumonia, empirical therapy should be started as soon as possible. The first step in treatment is a risk assessment to know whether the patient should be treated in an outpatient or inpatient setting. Cardiopulmonary conditions, age, and severity of symptoms affect risk for bacterial pneumonia, especially CAP.[8][9][10]

An expanded CURB-65 or CURB-65 pneumonia severity score can be used for risk quantification. It includes C = Confusion, U = Uremia (BUN greater than 20 mg/dL), R = Respiratory rate (greater than 30 per min), B = B.P (BP less than 90/60 mmHg) and age greater than 65 years. One point is scored for each previously mentioned risk factor. If the total of the score is 2 or more than 2, it indicates hospital admission. If the total is 4 or more than 4, it indicates ICU admission. Recommended therapy for different settings are as follows:

  • Outpatient Setting: For patients having comorbid conditions ( e.g., diabetes, malignancy, etc.) the regimen is "fluoroquinolone" or "beta-lactams + macrolide." For patients with no comorbid conditions, we can use "macrolide" or "doxycycline" empirically. Testing is usually not performed as the empiric regimen is almost always successful.
  • Inpatient Setting (non-ICU): Recommended therapy is fluoroquinolone or macrolide + beta-lactam.
  • Inpatient setting (ICU): Recommended therapy is beta-lactam + macrolide or beta-lactam + fluoroquinolone.

After getting a culture-positive lab result, therapies should be directed to the culture-specific pathogen.

The patient also can benefit from smoking cessation counseling and influenza and pneumococcal vaccination.

All patients treated at home should be scheduled for a follow-up visit within 2 days to assess any complication of pneumonia.

Nursing Management

  • Obtain blood work and check cultures
  • Hydrate the patient
  • Administer antibiotics as ordered
  • Keep patient comfortable and warm
  • Perform suction as required
  • Measure ins and out
  • Manage pain and cough
  • Promote nutrition
  • Administer oxygen as needed
  • Provide rest
  • Teach patient hand washing

When To Seek Help

  • Altered mental status
  • Dyspnea
  • Low oxygen saturations
  • Unstable hemodynamics
  • Fever
  • Unresponsive
  • Copious sputum production and respiratory distress

Outcome Identification

  • Normal vitals
  • No dyspnea or fever
  • Able to ambulate
  • Energetic

Monitoring

  • Vitals
  • Chest auscultation
  • Checking cultures and antibiotic sensitivity
  • Monitoring neurovitals
  • Ins and Outs
  • Ambulation
  • Diet

Coordination of Care

The management of a pneumonia is multidisciplinary. Besides the administration of antibiotics, these patients often require chest physical therapy, a dietary consult, physical therapy to help regain muscle mass and a dental consult. The key is to educate the patient on discontinuation of smoking and abstaining from alcohol. Further, patients should be encouraged to get the appropriate influenza and pneumococcal vaccines. Finally, it is important to educate the patient on compliance with antibiotics if they want a complete resolution of the infectious process.[10][11] (Level V)

Outcomes

In healthy people, the outcome after a bacterial pneumonia is excellent. However, in people with advanced age, lung disease, immunosuppression, infection with aggressive gram-negative organisms (Klebsiella) and other comorbidities, the outcomes are usually poor. When a pneumonia is left untreated, it carries a mortality in excess of 25%. Pneumonia can also lead to extensive lung damage and lead to residual impairment in lung function. Other reported complications of pneumonia that occur in 1-5% of patients include lung abscess, empyema, and bronchiectasis.[12][13] (Level V)

Health Teaching and Health Promotion

  • Get vaccinated against pneumococcus and influenza
  • Eat healthy
  • Ambulate
  • Wash hands

Risk Management

Call a physician if:

  • Unstable hemodynamics
  • Fever
  • Copious sputum production
  • Respiratory distress
  • Loss of consciousness
  • Altered mental status

Discharge Planning

  • Get vaccinated against pneumococcus and influenza
  • Eat healthy
  • Ambulate
  • Wash hands
  • Follow up with a clinician
  • Exercise regularly

Pearls and Other issues

The management of pneumonia is with an interprofessional team. The reason is that most patients are managed as outpatients but if not properly treated, the morbidity and mortality are high.

Besides the administration of antibiotics, these patients often require chest physical therapy, a dietary consult, physical therapy to help regain muscle mass and a dental consult. The key is to educate the patient on the discontinuation of smoking and abstaining from alcohol.

Patients need to be referred to a dietitian to ensure that they are eating healthy.

Further, the clinicians should encourage patients to get appropriate influenza and pneumococcal vaccines. The pharmacist should not only teach about antibiotic compliance but ensure that the patient is prescribed the right antibiotics aimed at the target organism.


Details

Nurse Editor

Asheley Headley

Editor:

Sandeep Sharma

Updated:

2/26/2024 10:10:40 PM

References

[1]

Yousaf Kazmi S. The etymology of microbial nomenclature and the diseases these cause in a historical perspective. Saudi journal of biological sciences. 2022 Nov:29(11):103454. doi: 10.1016/j.sjbs.2022.103454. Epub 2022 Sep 23     [PubMed PMID: 36248774]

[2]

Torres A, Cilloniz C, Niederman MS, Menéndez R, Chalmers JD, Wunderink RG, van der Poll T. Pneumonia. Nature reviews. Disease primers. 2021 Apr 8:7(1):25. doi: 10.1038/s41572-021-00259-0. Epub 2021 Apr 8     [PubMed PMID: 33833230]

[3]

Grief SN, Loza JK. Guidelines for the Evaluation and Treatment of Pneumonia. Primary care. 2018 Sep:45(3):485-503. doi: 10.1016/j.pop.2018.04.001. Epub     [PubMed PMID: 30115336]

[4]

Ashurst JV, Dawson A. Klebsiella Pneumonia. StatPearls. 2024 Jan:():     [PubMed PMID: 30085546]

[5]

Mackenzie G. The definition and classification of pneumonia. Pneumonia (Nathan Qld.). 2016:8():14. doi: 10.1186/s41479-016-0012-z. Epub 2016 Aug 22     [PubMed PMID: 28702293]

[6]

Miyashita N. Atypical pneumonia: Pathophysiology, diagnosis, and treatment. Respiratory investigation. 2022 Jan:60(1):56-67. doi: 10.1016/j.resinv.2021.09.009. Epub 2021 Nov 5     [PubMed PMID: 34750083]

[7]

Micek ST, Kollef KE, Reichley RM, Roubinian N, Kollef MH. Health care-associated pneumonia and community-acquired pneumonia: a single-center experience. Antimicrobial agents and chemotherapy. 2007 Oct:51(10):3568-73     [PubMed PMID: 17682100]

[8]

Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, Napolitano LM, O'Grady NP, Bartlett JG, Carratalà J, El Solh AA, Ewig S, Fey PD, File TM Jr, Restrepo MI, Roberts JA, Waterer GW, Cruse P, Knight SL, Brozek JL. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2016 Sep 1:63(5):e61-e111. doi: 10.1093/cid/ciw353. Epub 2016 Jul 14     [PubMed PMID: 27418577]

[9]

Akter S, Shamsuzzaman SM, Jahan F. Community acquired bacterial pneumonia: aetiology, laboratory detection and antibiotic susceptibility pattern. The Malaysian journal of pathology. 2014 Aug:36(2):97-103     [PubMed PMID: 25194532]

[10]

Shoar S, Musher DM. Etiology of community-acquired pneumonia in adults: a systematic review. Pneumonia (Nathan Qld.). 2020:12():11. doi: 10.1186/s41479-020-00074-3. Epub 2020 Oct 5     [PubMed PMID: 33024653]

[11]

Carugati M, Aliberti S, Sotgiu G, Blasi F, Gori A, Menendez R, Encheva M, Gallego M, Leuschner P, Ruiz-Buitrago S, Battaglia S, Fantini R, Pascual-Guardia S, Marin-Corral J, Restrepo MI, GLIMP Collaborators. Bacterial etiology of community-acquired pneumonia in immunocompetent hospitalized patients and appropriateness of empirical treatment recommendations: an international point-prevalence study. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2020 Aug:39(8):1513-1525. doi: 10.1007/s10096-020-03870-3. Epub 2020 Apr 3     [PubMed PMID: 32242314]

[12]

Røysted W, Simonsen Ø, Jenkins A, Sarjomaa M, Svendsen MV, Ragnhildstveit E, Tveten Y, Kanestrøm A, Waage H, Ringstad J. Aetiology and risk factors of community-acquired pneumonia in hospitalized patients in Norway. The clinical respiratory journal. 2016 Nov:10(6):756-764. doi: 10.1111/crj.12283. Epub 2015 Apr 6     [PubMed PMID: 25764275]

[13]

Peto L, Nadjm B, Horby P, Ngan TT, van Doorn R, Van Kinh N, Wertheim HF. The bacterial aetiology of adult community-acquired pneumonia in Asia: a systematic review. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2014 Jun:108(6):326-37. doi: 10.1093/trstmh/tru058. Epub 2014 Apr 29     [PubMed PMID: 24781376]

[14]

Niederman MS, Cilloniz C. Aspiration pneumonia. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia. 2022 Apr:35 Suppl 1(Suppl 1):73-77. doi: 10.37201/req/s01.17.2022. Epub 2022 Apr 22     [PubMed PMID: 35488832]

[15]

Lynch JP 3rd. Hospital-acquired pneumonia: risk factors, microbiology, and treatment. Chest. 2001 Feb:119(2 Suppl):373S-384S     [PubMed PMID: 11171773]

[16]

Htoutou Sedláková M, Pudová V, Kolář M. [Bacterial pathogens causing hospital-acquired pneumonia - a multicenter study in the Czech Republic]. Klinicka mikrobiologie a infekcni lekarstvi. 2015 Mar:21(1):10-4     [PubMed PMID: 26098488]

[17]

Werarak P, Kiratisin P, Thamlikitkul V. Hospital-acquired pneumonia and ventilator-associated pneumonia in adults at Siriraj Hospital: etiology, clinical outcomes, and impact of antimicrobial resistance. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2010 Jan:93 Suppl 1():S126-38     [PubMed PMID: 20364567]

[18]

Feng DY, Zhou YQ, Zou XL, Zhou M, Zhu JX, Wang YH, Zhang TT. Differences in microbial etiology between hospital-acquired pneumonia and ventilator-associated pneumonia: a single-center retrospective study in Guang Zhou. Infection and drug resistance. 2019:12():993-1000. doi: 10.2147/IDR.S204671. Epub 2019 Apr 29     [PubMed PMID: 31118705]

[19]

Manikam L, Lakhanpaul M. Epidemiology of community acquired pneumonia. Paediatrics and child health. 2012 Jul:22(7):299-306. doi: 10.1016/j.paed.2012.05.002. Epub 2012 Jun 25     [PubMed PMID: 32362935]

[20]

Bjarnason A, Westin J, Lindh M, Andersson LM, Kristinsson KG, Löve A, Baldursson O, Gottfredsson M. Incidence, Etiology, and Outcomes of Community-Acquired Pneumonia: A Population-Based Study. Open forum infectious diseases. 2018 Feb:5(2):ofy010. doi: 10.1093/ofid/ofy010. Epub 2018 Feb 8     [PubMed PMID: 29479548]

[21]

Partouche H, Lepoutre A, Vaure CBD, Poisson T, Toubiana L, Gilberg S. Incidence of all-cause adult community-acquired pneumonia in primary care settings in France. Medecine et maladies infectieuses. 2018 Sep:48(6):389-395. doi: 10.1016/j.medmal.2018.02.012. Epub 2018 Apr 12     [PubMed PMID: 29656842]

[22]

Zhu YG,Tang XD,Lu YT,Zhang J,Qu JM, Contemporary Situation of Community-acquired Pneumonia in China: A Systematic Review. Journal of translational internal medicine. 2018 Mar;     [PubMed PMID: 29607301]

[23]

Armstrong GL, Conn LA, Pinner RW. Trends in infectious disease mortality in the United States during the 20th century. JAMA. 1999 Jan 6:281(1):61-6     [PubMed PMID: 9892452]

[24]

Ramirez JA, Wiemken TL, Peyrani P, Arnold FW, Kelley R, Mattingly WA, Nakamatsu R, Pena S, Guinn BE, Furmanek SP, Persaud AK, Raghuram A, Fernandez F, Beavin L, Bosson R, Fernandez-Botran R, Cavallazzi R, Bordon J, Valdivieso C, Schulte J, Carrico RM, University of Louisville Pneumonia Study Group. Adults Hospitalized With Pneumonia in the United States: Incidence, Epidemiology, and Mortality. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2017 Nov 13:65(11):1806-1812. doi: 10.1093/cid/cix647. Epub     [PubMed PMID: 29020164]

[25]

Brown JD, Harnett J, Chambers R, Sato R. The relative burden of community-acquired pneumonia hospitalizations in older adults: a retrospective observational study in the United States. BMC geriatrics. 2018 Apr 16:18(1):92. doi: 10.1186/s12877-018-0787-2. Epub 2018 Apr 16     [PubMed PMID: 29661135]

[26]

Mizgerd JP. Lung infection--a public health priority. PLoS medicine. 2006 Feb:3(2):e76     [PubMed PMID: 16401173]

[27]

Shin EJ, Kim Y, Jeong JY, Jung YM, Lee MH, Chung EH. The changes of prevalence and etiology of pediatric pneumonia from National Emergency Department Information System in Korea, between 2007 and 2014. Korean journal of pediatrics. 2018 Sep:61(9):291-300. doi: 10.3345/kjp.2017.06100. Epub 2018 Sep 15     [PubMed PMID: 30274507]

[28]

Lutfiyya MN, Henley E, Chang LF, Reyburn SW. Diagnosis and treatment of community-acquired pneumonia. American family physician. 2006 Feb 1:73(3):442-50     [PubMed PMID: 16477891]

[29]

Labarere J, Stone RA, Obrosky DS, Yealy DM, Meehan TP, Fine JM, Graff LG, Fine MJ. Comparison of outcomes for low-risk outpatients and inpatients with pneumonia: A propensity-adjusted analysis. Chest. 2007 Feb:131(2):480-8     [PubMed PMID: 17296651]

[30]

Theilacker C, Sprenger R, Leverkus F, Walker J, Häckl D, von Eiff C, Schiffner-Rohe J. Population-based incidence and mortality of community-acquired pneumonia in Germany. PloS one. 2021:16(6):e0253118. doi: 10.1371/journal.pone.0253118. Epub 2021 Jun 15     [PubMed PMID: 34129632]

[31]

Arnold FW, Wiemken TL, Peyrani P, Ramirez JA, Brock GN, CAPO authors. Mortality differences among hospitalized patients with community-acquired pneumonia in three world regions: results from the Community-Acquired Pneumonia Organization (CAPO) International Cohort Study. Respiratory medicine. 2013 Jul:107(7):1101-11. doi: 10.1016/j.rmed.2013.04.003. Epub 2013 May 6     [PubMed PMID: 23660396]

[32]

Angus DC, Marrie TJ, Obrosky DS, Clermont G, Dremsizov TT, Coley C, Fine MJ, Singer DE, Kapoor WN. Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteria. American journal of respiratory and critical care medicine. 2002 Sep 1:166(5):717-23     [PubMed PMID: 12204871]

[33]

Minogue MF, Coley CM, Fine MJ, Marrie TJ, Kapoor WN, Singer DE. Patients hospitalized after initial outpatient treatment for community-acquired pneumonia. Annals of emergency medicine. 1998 Mar:31(3):376-80     [PubMed PMID: 9506497]

[34]

Montón C, Torres A. Lung inflammatory response in pneumonia. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace. 1998 Feb:53(1):56-63     [PubMed PMID: 9632909]

[35]

Korkmaz FT, Traber KE. Innate immune responses in pneumonia. Pneumonia (Nathan Qld.). 2023 Feb 25:15(1):4. doi: 10.1186/s41479-023-00106-8. Epub 2023 Feb 25     [PubMed PMID: 36829255]

[36]

Branger J, Knapp S, Weijer S, Leemans JC, Pater JM, Speelman P, Florquin S, van der Poll T. Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice. Infection and immunity. 2004 Feb:72(2):788-94     [PubMed PMID: 14742522]

[37]

Phillips-Houlbracq M, Ricard JD, Foucrier A, Yoder-Himes D, Gaudry S, Bex J, Messika J, Margetis D, Chatel J, Dobrindt U, Denamur E, Roux D. Pathophysiology of Escherichia coli pneumonia: Respective contribution of pathogenicity islands to virulence. International journal of medical microbiology : IJMM. 2018 Mar:308(2):290-296. doi: 10.1016/j.ijmm.2018.01.003. Epub 2018 Jan 5     [PubMed PMID: 29325882]

[38]

Nelson AL, Roche AM, Gould JM, Chim K, Ratner AJ, Weiser JN. Capsule enhances pneumococcal colonization by limiting mucus-mediated clearance. Infection and immunity. 2007 Jan:75(1):83-90     [PubMed PMID: 17088346]

[39]

Chaudhry R, Varshney AK, Malhotra P. Adhesion proteins of Mycoplasma pneumoniae. Frontiers in bioscience : a journal and virtual library. 2007 Jan 1:12():690-9     [PubMed PMID: 17127329]

[40]

Lucas CE, Brown E, Fields BS. Type IV pili and type II secretion play a limited role in Legionella pneumophila biofilm colonization and retention. Microbiology (Reading, England). 2006 Dec:152(Pt 12):3569-3573. doi: 10.1099/mic.0.2006/000497-0. Epub     [PubMed PMID: 17159209]

[41]

Xiang J, Rir-Sim-Ah J, Tesfaigzi Y. IL-9 and IL-13 induce mucous cell metaplasia that is reduced by IFN-gamma in a Bax-mediated pathway. American journal of respiratory cell and molecular biology. 2008 Mar:38(3):310-7     [PubMed PMID: 17901408]

[42]

Dellamonica J, Lerolle N, Sargentini C, Beduneau G, Di Marco F, Mercat A, Richard JC, Diehl JL, Mancebo J, Rouby JJ, Lu Q, Bernardin G, Brochard L. PEEP-induced changes in lung volume in acute respiratory distress syndrome. Two methods to estimate alveolar recruitment. Intensive care medicine. 2011 Oct:37(10):1595-604. doi: 10.1007/s00134-011-2333-y. Epub 2011 Aug 25     [PubMed PMID: 21866369]

[43]

Kass SM, Williams PM, Reamy BV. Pleurisy. American family physician. 2007 May 1:75(9):1357-64     [PubMed PMID: 17508531]

[44]

Reimel BA, Krishnadasen B, Cuschieri J, Klein MB, Gross J, Karmy-Jones R. Surgical management of acute necrotizing lung infections. Canadian respiratory journal. 2006 Oct:13(7):369-73     [PubMed PMID: 17036090]

[45]

Zinserling VA, Swistunov VV, Botvinkin AD, Stepanenko LA, Makarova AE. Lobar (croupous) pneumonia: old and new data. Infection. 2022 Feb:50(1):235-242. doi: 10.1007/s15010-021-01689-4. Epub 2021 Sep 1     [PubMed PMID: 34472009]

[46]

Torres A, Peetermans WE, Viegi G, Blasi F. Risk factors for community-acquired pneumonia in adults in Europe: a literature review. Thorax. 2013 Nov:68(11):1057-65. doi: 10.1136/thoraxjnl-2013-204282. Epub     [PubMed PMID: 24130229]

[47]

Almirall J, Serra-Prat M, Bolíbar I, Balasso V. Risk Factors for Community-Acquired Pneumonia in Adults: A Systematic Review of Observational Studies. Respiration; international review of thoracic diseases. 2017:94(3):299-311. doi: 10.1159/000479089. Epub 2017 Jul 25     [PubMed PMID: 28738364]

[48]

Johnston ID, Strachan DP, Anderson HR. Effect of pneumonia and whooping cough in childhood on adult lung function. The New England journal of medicine. 1998 Feb 26:338(9):581-7     [PubMed PMID: 9475765]

[49]

Hind CR. Pulmonary complications of intravenous drug misuse. 2. Infective and HIV related complications. Thorax. 1990 Dec:45(12):957-61     [PubMed PMID: 2281430]

[50]

Straus WL, Plouffe JF, File TM Jr, Lipman HB, Hackman BH, Salstrom SJ, Benson RF, Breiman RF. Risk factors for domestic acquisition of legionnaires disease. Ohio legionnaires Disease Group. Archives of internal medicine. 1996 Aug 12-26:156(15):1685-92     [PubMed PMID: 8694667]

[51]

Jernigan DB, Hofmann J, Cetron MS, Genese CA, Nuorti JP, Fields BS, Benson RF, Carter RJ, Edelstein PH, Guerrero IC, Paul SM, Lipman HB, Breiman R. Outbreak of Legionnaires' disease among cruise ship passengers exposed to a contaminated whirlpool spa. Lancet (London, England). 1996 Feb 24:347(9000):494-9     [PubMed PMID: 8596266]

[52]

Mouchtouri VA, Rudge JW. Legionnaires' Disease in Hotels and Passenger Ships: A Systematic Review of Evidence, Sources, and Contributing Factors. Journal of travel medicine. 2015 Sep-Oct:22(5):325-37. doi: 10.1111/jtm.12225. Epub 2015 Jul 29     [PubMed PMID: 26220258]

[53]

Howie SR, Schellenberg J, Chimah O, Ideh RC, Ebruke BE, Oluwalana C, Mackenzie G, Jallow M, Njie M, Donkor S, Dionisio KL, Goldberg G, Fornace K, Bottomley C, Hill PC, Grant CC, Corrah T, Prentice AM, Ezzati M, Greenwood BM, Smith PG, Adegbola RA, Mulholland K. Childhood pneumonia and crowding, bed-sharing and nutrition: a case-control study from The Gambia. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 2016 Oct:20(10):1405-1415     [PubMed PMID: 27725055]

[54]

Pelissari DM, Diaz-Quijano FA. Household crowding as a potential mediator of socioeconomic determinants of tuberculosis incidence in Brazil. PloS one. 2017:12(4):e0176116. doi: 10.1371/journal.pone.0176116. Epub 2017 Apr 18     [PubMed PMID: 28419146]

[55]

Taylor-Robinson D. The importance of mycoplasmas in respiratory infections. Developments in biological standardization. 1975:28():86-100     [PubMed PMID: 1092579]

[56]

Blasi F, Tarsia P, Arosio C, Fagetti L, Allegra L. Epidemiology of Chlamydia pneumoniae. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 1998 Jan:4 Suppl 4():S1-S6     [PubMed PMID: 11869264]

[57]

Berk Y, Klaassen CH, Mouton JW, Meis JF. [An outbreak of psittacosis at a bird-fanciers fair in the Netherlands]. Nederlands tijdschrift voor geneeskunde. 2008 Aug 23:152(34):1889-92     [PubMed PMID: 18788682]

[58]

Tärnvik A, Berglund L. Tularaemia. The European respiratory journal. 2003 Feb:21(2):361-73     [PubMed PMID: 12608453]

[59]

Eden JS, Rose K, Ng J, Shi M, Wang Q, Sintchenko V, Holmes EC. Francisella tularensis ssp. holarctica in Ringtail Possums, Australia. Emerging infectious diseases. 2017 Jul:23(7):1198-1201. doi: 10.3201/eid2307.161863. Epub     [PubMed PMID: 28628459]

[60]

Cleri DJ, Vernaleo JR, Lombardi LJ, Rabbat MS, Mathew A, Marton R, Reyelt MC. Plague pneumonia disease caused by Yersinia pestis. Seminars in respiratory infections. 1997 Mar:12(1):12-23     [PubMed PMID: 9097371]

[61]

Hill MK, Sanders CV. Leptospiral pneumonia. Seminars in respiratory infections. 1997 Mar:12(1):44-9     [PubMed PMID: 9097376]

[62]

Smit LA, van der Sman-de Beer F, Opstal-van Winden AW, Hooiveld M, Beekhuizen J, Wouters IM, Yzermans J, Heederik D. Q fever and pneumonia in an area with a high livestock density: a large population-based study. PloS one. 2012:7(6):e38843. doi: 10.1371/journal.pone.0038843. Epub 2012 Jun 7     [PubMed PMID: 22685612]

[63]

Flint J, Dalton CB, Merritt TD, Graves S, Ferguson JK, Osbourn M, Eastwood K, Durrheim DN. Q fever and contact with kangaroos in New South Wales. Communicable diseases intelligence quarterly report. 2016 Jun 30:40(2):E202-3     [PubMed PMID: 27522129]

[64]

Goodrick I, Todd G, Stewart J. Soil characteristics influencing the spatial distribution of melioidosis in Far North Queensland, Australia. Epidemiology and infection. 2018 Sep:146(12):1602-1607. doi: 10.1017/S0950268818001188. Epub 2018 Jul 4     [PubMed PMID: 29970213]

[65]

Gransden WR, Leibovici L, Eykyn SJ, Pitlik SD, Samra Z, Konisberger H, Drucker M, Phillips I. Risk factors and a clinical index for diagnosis of Pseudomonas aeruginosa bacteremia. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 1995 Feb:1(2):119-123     [PubMed PMID: 11866739]

[66]

BELCHER JR. The pulmonary complications of dysphagia. Thorax. 1949 Mar:4(1):44-56     [PubMed PMID: 18113256]

[67]

Manabe T, Teramoto S, Tamiya N, Okochi J, Hizawa N. Risk Factors for Aspiration Pneumonia in Older Adults. PloS one. 2015:10(10):e0140060. doi: 10.1371/journal.pone.0140060. Epub 2015 Oct 7     [PubMed PMID: 26444916]

[68]

Langmore SE,Terpenning MS,Schork A,Chen Y,Murray JT,Lopatin D,Loesche WJ, Predictors of aspiration pneumonia: how important is dysphagia? Dysphagia. 1998 Spring;     [PubMed PMID: 9513300]

[69]

Chin CL, Manzel LJ, Lehman EE, Humlicek AL, Shi L, Starner TD, Denning GM, Murphy TF, Sethi S, Look DC. Haemophilus influenzae from patients with chronic obstructive pulmonary disease exacerbation induce more inflammation than colonizers. American journal of respiratory and critical care medicine. 2005 Jul 1:172(1):85-91     [PubMed PMID: 15805181]

[70]

Herrod HG, Gross S, Insel R. Selective antibody deficiency to Haemophilus influenzae type B capsular polysaccharide vaccination in children with recurrent respiratory tract infection. Journal of clinical immunology. 1989 Sep:9(5):429-34     [PubMed PMID: 2621246]

[71]

Justiz Vaillant AA, Naik R. HIV-1–Associated Opportunistic Infections. StatPearls. 2024 Jan:():     [PubMed PMID: 30969609]

[72]

Metlay JP, Kapoor WN, Fine MJ. Does this patient have community-acquired pneumonia? Diagnosing pneumonia by history and physical examination. JAMA. 1997 Nov 5:278(17):1440-5     [PubMed PMID: 9356004]

[73]

. Pneumonia. Hall's journal of health. 1880 Jan:27(1):1-3     [PubMed PMID: 36489311]

[74]

Miravitlles M, Kruesmann F, Haverstock D, Perroncel R, Choudhri SH, Arvis P. Sputum colour and bacteria in chronic bronchitis exacerbations: a pooled analysis. The European respiratory journal. 2012 Jun:39(6):1354-60. doi: 10.1183/09031936.00042111. Epub 2011 Oct 27     [PubMed PMID: 22034649]

[75]

WELFORD NT. Recovery from primary Friedlander pneumonia (type B) on therapy with sulfadiazine and penicillin. The Illinois medical journal. 1946 Sep:90():185-7     [PubMed PMID: 20998872]

[76]

Bartlett JG, Finegold SM. Anaerobic infections of the lung and pleural space. The American review of respiratory disease. 1974 Jul:110(1):56-77     [PubMed PMID: 4834618]

[77]

Johnson JD, Raff MJ, Van Arsdall JA. Neurologic manifestations of Legionnaires' disease. Medicine. 1984 Sep:63(5):303-10     [PubMed PMID: 6088942]

[78]

Chitasombat MN, Ratchatanawin N, Visessiri Y. Disseminated extrapulmonary Legionella pneumophila infection presenting with panniculitis: case report and literature review. BMC infectious diseases. 2018 Sep 17:18(1):467. doi: 10.1186/s12879-018-3378-0. Epub 2018 Sep 17     [PubMed PMID: 30223775]

[79]

Wipf JE, Lipsky BA, Hirschmann JV, Boyko EJ, Takasugi J, Peugeot RL, Davis CL. Diagnosing pneumonia by physical examination: relevant or relic? Archives of internal medicine. 1999 May 24:159(10):1082-7     [PubMed PMID: 10335685]

[80]

Htun TP, Sun Y, Chua HL, Pang J. Clinical features for diagnosis of pneumonia among adults in primary care setting: A systematic and meta-review. Scientific reports. 2019 May 20:9(1):7600. doi: 10.1038/s41598-019-44145-y. Epub 2019 May 20     [PubMed PMID: 31110214]

[81]

Saldías F, Méndez JI, Ramírez D, Díaz O. [Predictive value of history and physical examination for the diagnosis of community-acquired pneumonia in adults: a literature review]. Revista medica de Chile. 2007 Apr:135(4):517-28     [PubMed PMID: 17554463]

[82]

Claudius I, Baraff LJ. Pediatric emergencies associated with fever. Emergency medicine clinics of North America. 2010 Feb:28(1):67-84, vii-viii. doi: 10.1016/j.emc.2009.09.002. Epub     [PubMed PMID: 19945599]

[83]

Singhi S, Dhawan A, Kataria S, Walia BN. Clinical signs of pneumonia in infants under 2 months. Archives of disease in childhood. 1994 May:70(5):413-7     [PubMed PMID: 8017964]

[84]

Kevat PM, Morpeth M, Graham H, Gray AZ. A systematic review of the clinical features of pneumonia in children aged 5-9 years: Implications for guidelines and research. Journal of global health. 2022:12():10002. doi: 10.7189/jogh.12.10002. Epub 2022 Mar 26     [PubMed PMID: 35356655]

[85]

Ayalon I, Glatstein MM, Zaidenberg-Israeli G, Scolnik D, Ben Tov A, Ben Sira L, Reif S. The role of physical examination in establishing the diagnosis of pneumonia. Pediatric emergency care. 2013 Aug:29(8):893-6. doi: 10.1097/PEC.0b013e31829e7d6a. Epub     [PubMed PMID: 23903669]

[86]

Musgrave T, Verghese A. Clinical features of pneumonia in the elderly. Seminars in respiratory infections. 1990 Dec:5(4):269-75     [PubMed PMID: 2093972]

[87]

Niederman MS, Fein AM. Sepsis syndrome, the adult respiratory distress syndrome, and nosocomial pneumonia. A common clinical sequence. Clinics in chest medicine. 1990 Dec:11(4):633-56     [PubMed PMID: 2268994]

[88]

Cunha BA, Quintiliani R. The atypical pneumonias: a diagnostic and therapeutic approach. Postgraduate medicine. 1979 Sep:66(3):95-102     [PubMed PMID: 471855]

[89]

Newman MG. Anaerobic oral and dental infection. Reviews of infectious diseases. 1984 Mar-Apr:6 Suppl 1():S107-14     [PubMed PMID: 6372018]

[90]

Dodiuk-Gad R, Cohen E, Ziv M, Goldstein LH, Chazan B, Shafer J, Sprecher H, Elias M, Keness Y, Rozenman D. Cutaneous nocardiosis: report of two cases and review of the literature. International journal of dermatology. 2010 Dec:49(12):1380-5     [PubMed PMID: 21155087]

[91]

Roberts DB. The etiology of bullous myringitis and the role of mycoplasmas in ear disease: a review. Pediatrics. 1980 Apr:65(4):761-6     [PubMed PMID: 7367083]

[92]

Barberis I, Bragazzi NL, Galluzzo L, Martini M. The history of tuberculosis: from the first historical records to the isolation of Koch's bacillus. Journal of preventive medicine and hygiene. 2017 Mar:58(1):E9-E12     [PubMed PMID: 28515626]

[93]

Varo R, Bila R, Saavedra B, Sitoe A, Uamusse A, Ribó-Aristizabal JL, García-Basteiro AL. Paraplegia and spinal deformity in a Mozambican child with Pott's disease and tuberculous scrofula. Lancet (London, England). 2019 Nov 2:394(10209):1651. doi: 10.1016/S0140-6736(19)32484-5. Epub     [PubMed PMID: 31690448]

[94]

Sezer B, Akdeniz BG, Günbay S, Hilmioğlu-Polat S, Başdemir G. Actinomycosis osteomyelitis of the jaws: Report of four cases and a review of the literature. Journal of dental sciences. 2017 Sep:12(3):301-307. doi: 10.1016/j.jds.2013.02.031. Epub 2013 Sep 20     [PubMed PMID: 30895066]

[95]

Mabeza GF, Macfarlane J. Pulmonary actinomycosis. The European respiratory journal. 2003 Mar:21(3):545-51     [PubMed PMID: 12662015]

[96]

Reyes LF, Bastidas AR, Quintero ET, Frías JS, Aguilar ÁF, Pedreros KD, Herrera M, Saza LD, Nonzoque AP, Bello LE, Hernández MD, Carmona GA, Jaimes A, Ramírez SM, Murillo N. Performance of the CORB (Confusion, Oxygenation, Respiratory Rate, and Blood Pressure) Scale for the Prediction of Clinical Outcomes in Pneumonia. Canadian respiratory journal. 2022:2022():4493777. doi: 10.1155/2022/4493777. Epub 2022 Jun 3     [PubMed PMID: 35692950]

[97]

Memon RA, Rashid MA, Avva S, Anirudh Chunchu V, Ijaz H, Ahmad Ganaie Z, Kabir Dar A, Ali N. The Use of the SMART-COP Score in Predicting Severity Outcomes Among Patients With Community-Acquired Pneumonia: A Meta-Analysis. Cureus. 2022 Jul:14(7):e27248. doi: 10.7759/cureus.27248. Epub 2022 Jul 25     [PubMed PMID: 36043007]

[98]

Karmakar G, Wilsher M. Use of the 'CURB 65' score in hospital practice. Internal medicine journal. 2010 Dec:40(12):828-32. doi: 10.1111/j.1445-5994.2009.02062.x. Epub     [PubMed PMID: 19811559]

[99]

Quinton LJ,Walkey AJ,Mizgerd JP, Integrative Physiology of Pneumonia. Physiological reviews. 2018 Jul 1     [PubMed PMID: 29767563]

[100]

Johansson N, Kalin M, Giske CG, Hedlund J. Quantitative detection of Streptococcus pneumoniae from sputum samples with real-time quantitative polymerase chain reaction for etiologic diagnosis of community-acquired pneumonia. Diagnostic microbiology and infectious disease. 2008 Mar:60(3):255-61     [PubMed PMID: 18036762]

[101]

Strålin K, Törnqvist E, Kaltoft MS, Olcén P, Holmberg H. Etiologic diagnosis of adult bacterial pneumonia by culture and PCR applied to respiratory tract samples. Journal of clinical microbiology. 2006 Feb:44(2):643-5     [PubMed PMID: 16455935]

[102]

Kang YA, Kwon SY, Yoon HI, Lee JH, Lee CT. Role of C-reactive protein and procalcitonin in differentiation of tuberculosis from bacterial community acquired pneumonia. The Korean journal of internal medicine. 2009 Dec:24(4):337-42. doi: 10.3904/kjim.2009.24.4.337. Epub 2009 Nov 27     [PubMed PMID: 19949732]

[103]

Waterer GW, Wunderink RG. The influence of the severity of community-acquired pneumonia on the usefulness of blood cultures. Respiratory medicine. 2001 Jan:95(1):78-82     [PubMed PMID: 11207022]

[104]

Kennedy M, Bates DW, Wright SB, Ruiz R, Wolfe RE, Shapiro NI. Do emergency department blood cultures change practice in patients with pneumonia? Annals of emergency medicine. 2005 Nov:46(5):393-400     [PubMed PMID: 16271664]

[105]

Murray PR, Washington JA. Microscopic and baceriologic analysis of expectorated sputum. Mayo Clinic proceedings. 1975 Jun:50(6):339-44     [PubMed PMID: 1127999]

[106]

Rosón B, Carratalà J, Verdaguer R, Dorca J, Manresa F, Gudiol F. Prospective study of the usefulness of sputum Gram stain in the initial approach to community-acquired pneumonia requiring hospitalization. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2000 Oct:31(4):869-74     [PubMed PMID: 11049763]

[107]

Saubolle MA, Sussland D. Nocardiosis: review of clinical and laboratory experience. Journal of clinical microbiology. 2003 Oct:41(10):4497-501     [PubMed PMID: 14532173]

[108]

Muricy EC, Lemes RA, Bombarda S, Ferrazoli L, Chimara E. Differentiation between Nocardia spp. and Mycobacterium spp.: Critical aspects for bacteriological diagnosis. Revista do Instituto de Medicina Tropical de Sao Paulo. 2014 Sep-Oct:56(5):397-401     [PubMed PMID: 25229219]

[109]

Burckhardt I, Panitz J, Burckhardt F, Zimmermann S. Identification of Streptococcus pneumoniae: Development of a Standardized Protocol for Optochin Susceptibility Testing Using Total Lab Automation. BioMed research international. 2017:2017():4174168. doi: 10.1155/2017/4174168. Epub 2017 Mar 19     [PubMed PMID: 28401155]

[110]

Porter BD, Ortika BD, Satzke C. Capsular Serotyping of Streptococcus pneumoniae by latex agglutination. Journal of visualized experiments : JoVE. 2014 Sep 25:(91):51747. doi: 10.3791/51747. Epub 2014 Sep 25     [PubMed PMID: 25285991]

[111]

Arjun R, Padmanabhan A, Reddy Attunuru BP, Gupta P. Disseminated nocardiosis masquerading as metastatic malignancy. Lung India : official organ of Indian Chest Society. 2016 Jul-Aug:33(4):434-8. doi: 10.4103/0970-2113.184920. Epub     [PubMed PMID: 27578940]

[112]

Kelava I, Marecic V, Fucak P, Ivek E, Kolaric D, Ozanic M, Mihelcic M, Santic M. Optimisation of External Factors for the Growth of Francisella novicida within Dictyostelium discoideum. BioMed research international. 2020:2020():6826983. doi: 10.1155/2020/6826983. Epub 2020 Jan 20     [PubMed PMID: 32090107]

[113]

Bayot ML, Bragg BN. Antimicrobial Susceptibility Testing. StatPearls. 2024 Jan:():     [PubMed PMID: 30969536]

[114]

Schuetz P, Haubitz S, Christ-Crain M, Albrich WC, Zimmerli W, Mueller B, ProHOSP Study Group. Hyponatremia and anti-diuretic hormone in Legionnaires' disease. BMC infectious diseases. 2013 Dec 11:13():585. doi: 10.1186/1471-2334-13-585. Epub 2013 Dec 11     [PubMed PMID: 24330484]

[115]

Helms CM, Viner JP, Sturm RH, Renner ED, Johnson W. Comparative features of pneumococcal, mycoplasmal, and Legionnaires' disease pneumonias. Annals of internal medicine. 1979 Apr:90(4):543-7     [PubMed PMID: 434631]

[116]

Franquet T. Imaging of Community-acquired Pneumonia. Journal of thoracic imaging. 2018 Sep:33(5):282-294. doi: 10.1097/RTI.0000000000000347. Epub     [PubMed PMID: 30036297]

[117]

Macfarlane J, Rose D. Radiographic features of staphylococcal pneumonia in adults and children. Thorax. 1996 May:51(5):539-40     [PubMed PMID: 8711686]

[118]

Joseph JP, Meddows TR, Webster DP, Newton JD, Myerson SG, Prendergast B, Scarborough M, Herring N. Prioritizing echocardiography in Staphylococcus aureus bacteraemia. The Journal of antimicrobial chemotherapy. 2013 Feb:68(2):444-9. doi: 10.1093/jac/dks408. Epub 2012 Oct 30     [PubMed PMID: 23111851]

[119]

King P. Haemophilus influenzae and the lung (Haemophilus and the lung). Clinical and translational medicine. 2012 Jun 14:1(1):10. doi: 10.1186/2001-1326-1-10. Epub 2012 Jun 14     [PubMed PMID: 23369277]

[120]

Grover SB, Grover H, Antil N, Patra S, Sen MK, Nair D. Imaging Approach to Pulmonary Infections in the Immunocompromised Patient. The Indian journal of radiology & imaging. 2022 Mar:32(1):81-112. doi: 10.1055/s-0042-1743418. Epub 2022 May 27     [PubMed PMID: 35722641]

[121]

Schmidt AJ, Stark P. Radiographic findings in Klebsiella (Friedlander's) pneumonia: the bulging fissure sign. Seminars in respiratory infections. 1998 Mar:13(1):80-2     [PubMed PMID: 9543478]

[122]

Francis JB, Francis PB. Bulging (sagging) fissure sign in Hemophilus influenzae lobar pneumonia. Southern medical journal. 1978 Nov:71(11):1452-3     [PubMed PMID: 309660]

[123]

Raju S, Ghosh S, Mehta AC. Chest CT Signs in Pulmonary Disease: A Pictorial Review. Chest. 2017 Jun:151(6):1356-1374. doi: 10.1016/j.chest.2016.12.033. Epub 2017 Feb 16     [PubMed PMID: 28212835]

[124]

Sanchez Nieto JM, Carillo Alcaraz A. The role of bronchoalveolar lavage in the diagnosis of bacterial pneumonia. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 1995 Oct:14(10):839-50     [PubMed PMID: 8605896]

[125]

Hanretty AM, Gallagher JC. Shortened Courses of Antibiotics for Bacterial Infections: A Systematic Review of Randomized Controlled Trials. Pharmacotherapy. 2018 Jun:38(6):674-687. doi: 10.1002/phar.2118. Epub 2018 May 23     [PubMed PMID: 29679383]

[126]

Ayede AI, Kirolos A, Fowobaje KR, Williams LJ, Bakare AA, Oyewole OB, Olorunfemi OB, Kuna O, Iwuala NT, Oguntoye A, Kusoro SO, Okunlola ME, Qazi SA, Nair H, Falade AG, Campbell H. A prospective validation study in South-West Nigeria on caregiver report of childhood pneumonia and antibiotic treatment using Demographic and Health Survey (DHS) and Multiple Indicator Cluster Survey (MICS) questions. Journal of global health. 2018 Dec:8(2):020806. doi: 10.7189/jogh.08.020806. Epub     [PubMed PMID: 30254744]

[127]

Julián-Jiménez A, Adán Valero I, Beteta López A, Cano Martín LM, Fernández Rodríguez O, Rubio Díaz R, Sepúlveda Berrocal MA, González Del Castillo J, Candel González FJ, CAP group (community-acquired pneumonia) from the Infections in Emergencies - Sepsis Code working group. [Recommendations for the care of patients with community-acquired pneumonia in the Emergency Department]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia. 2018 Apr:31(2):186-202     [PubMed PMID: 29619807]

[128]

Torres A, Blasi F, Peetermans WE, Viegi G, Welte T. The aetiology and antibiotic management of community-acquired pneumonia in adults in Europe: a literature review. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2014 Jul:33(7):1065-79. doi: 10.1007/s10096-014-2067-1. Epub 2014 Feb 15     [PubMed PMID: 24532008]

[129]

Nayar S, Hasan A, Waghray P, Ramananthan S, Ahdal J, Jain R. Management of community-acquired bacterial pneumonia in adults: Limitations of current antibiotics and future therapies. Lung India : official organ of Indian Chest Society. 2019 Nov-Dec:36(6):525-533. doi: 10.4103/lungindia.lungindia_38_19. Epub     [PubMed PMID: 31670301]

[130]

Trad MA, Baisch A. Management of community-acquired pneumonia in an Australian regional hospital. The Australian journal of rural health. 2017 Apr:25(2):120-124. doi: 10.1111/ajr.12267. Epub 2015 Dec 21     [PubMed PMID: 26689428]

[131]

Ba B, Gaudin K, Désiré A, Phoeung T, Langlois MH, Behl CR, Unowsky J, Patel IH, Malick AW, Gomes M, White N, Kauss T. Ceftriaxone Absorption Enhancement for Noninvasive Administration as an Alternative to Injectable Solutions. Antimicrobial agents and chemotherapy. 2018 Dec:62(12):. doi: 10.1128/AAC.01170-18. Epub 2018 Nov 26     [PubMed PMID: 30348664]

[132]

Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, Griffin MR, Metersky ML, Musher DM, Restrepo MI, Whitney CG. Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. American journal of respiratory and critical care medicine. 2019 Oct 1:200(7):e45-e67. doi: 10.1164/rccm.201908-1581ST. Epub     [PubMed PMID: 31573350]

[133]

Sader HS, Huband MD, Castanheira M, Flamm RK. Pseudomonas aeruginosa Antimicrobial Susceptibility Results from Four Years (2012 to 2015) of the International Network for Optimal Resistance Monitoring Program in the United States. Antimicrobial agents and chemotherapy. 2017 Mar:61(3):. doi: 10.1128/AAC.02252-16. Epub 2017 Feb 23     [PubMed PMID: 28069652]

[134]

Plaisance KI, Mackowiak PA. Antipyretic therapy: physiologic rationale, diagnostic implications, and clinical consequences. Archives of internal medicine. 2000 Feb 28:160(4):449-56     [PubMed PMID: 10695685]

[135]

Rodríguez A, Mendia A, Sirvent JM, Barcenilla F, de la Torre-Prados MV, Solé-Violán J, Rello J, CAPUCI Study Group. Combination antibiotic therapy improves survival in patients with community-acquired pneumonia and shock. Critical care medicine. 2007 Jun:35(6):1493-8     [PubMed PMID: 17452932]

[136]

Uranga A, España PP, Bilbao A, Quintana JM, Arriaga I, Intxausti M, Lobo JL, Tomás L, Camino J, Nuñez J, Capelastegui A. Duration of Antibiotic Treatment in Community-Acquired Pneumonia: A Multicenter Randomized Clinical Trial. JAMA internal medicine. 2016 Sep 1:176(9):1257-65. doi: 10.1001/jamainternmed.2016.3633. Epub     [PubMed PMID: 27455166]

[137]

Lee JH, Park YH, Kang DR, Lee SJ, Lee MK, Kim SH, Yong SJ, Lee WY. Risk of Pneumonia Associated with Inhaled Corticosteroid in Patients with Chronic Obstructive Pulmonary Disease: A Korean Population-Based Study. International journal of chronic obstructive pulmonary disease. 2020:15():3397-3406. doi: 10.2147/COPD.S286149. Epub 2020 Dec 29     [PubMed PMID: 33402820]

[138]

De Pascale G, Bello G, Antonelli M. Steroids in severe pneumonia: a literature review. Minerva anestesiologica. 2011 Sep:77(9):902-10     [PubMed PMID: 21878872]

[139]

Harris P, Bennett A. Waterhouse-Friderichsen syndrome. The New England journal of medicine. 2001 Sep 13:345(11):841     [PubMed PMID: 11556316]

[140]

Hamilton D, Harris MD, Foweraker J, Gresham GA. Waterhouse-Friderichsen syndrome as a result of non-meningococcal infection. Journal of clinical pathology. 2004 Feb:57(2):208-9     [PubMed PMID: 14747454]

[141]

Saleem N, Kulkarni A, Snow TAC, Ambler G, Singer M, Arulkumaran N. Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials. Chest. 2023 Mar:163(3):484-497. doi: 10.1016/j.chest.2022.08.2229. Epub 2022 Sep 7     [PubMed PMID: 36087797]

[142]

Dequin PF, Meziani F, Quenot JP, Kamel T, Ricard JD, Badie J, Reignier J, Heming N, Plantefève G, Souweine B, Voiriot G, Colin G, Frat JP, Mira JP, Barbarot N, François B, Louis G, Gibot S, Guitton C, Giacardi C, Hraiech S, Vimeux S, L'Her E, Faure H, Herbrecht JE, Bouisse C, Joret A, Terzi N, Gacouin A, Quentin C, Jourdain M, Leclerc M, Coffre C, Bourgoin H, Lengellé C, Caille-Fénérol C, Giraudeau B, Le Gouge A, CRICS-TriGGERSep Network. Hydrocortisone in Severe Community-Acquired Pneumonia. The New England journal of medicine. 2023 May 25:388(21):1931-1941. doi: 10.1056/NEJMoa2215145. Epub 2023 Mar 21     [PubMed PMID: 36942789]

[143]

Ferrer M, Cosentini R, Nava S. The use of non-invasive ventilation during acute respiratory failure due to pneumonia. European journal of internal medicine. 2012 Jul:23(5):420-8. doi: 10.1016/j.ejim.2012.02.011. Epub 2012 Mar 28     [PubMed PMID: 22726370]

[144]

Dransfield MT, Crim C, Criner GJ, Day NC, Halpin DMG, Han MK, Jones CE, Kilbride S, LaFon D, Lipson DA, Lomas DA, Martin N, Martinez FJ, Singh D, Wise RA, Lange P. Risk of Exacerbation and Pneumonia with Single-Inhaler Triple versus Dual Therapy in IMPACT. Annals of the American Thoracic Society. 2021 May:18(5):788-798. doi: 10.1513/AnnalsATS.202002-096OC. Epub     [PubMed PMID: 33108212]

[145]

Heo JY, Song JY, Noh JY, Choi MJ, Yoon JG, Lee SN, Cheong HJ, Kim WJ. Effects of influenza immunization on pneumonia in the elderly. Human vaccines & immunotherapeutics. 2018 Mar 4:14(3):744-749. doi: 10.1080/21645515.2017.1405200. Epub 2017 Dec 19     [PubMed PMID: 29135343]

[146]

Baskaran V, Murray RL, Hunter A, Lim WS, McKeever TM. Effect of tobacco smoking on the risk of developing community acquired pneumonia: A systematic review and meta-analysis. PloS one. 2019:14(7):e0220204. doi: 10.1371/journal.pone.0220204. Epub 2019 Jul 18     [PubMed PMID: 31318967]

[147]

Connor E, Rasiah K, Hillock N. Utilisation of antimicrobials used to treat bacterial pneumonia in principal referral hospitals during the COVID-19 pandemic, Australia, 2020. Communicable diseases intelligence (2018). 2022 Feb 16:46():. doi: 10.33321/cdi.2022.46.6. Epub 2022 Feb 16     [PubMed PMID: 35168505]

[148]

Hsiao A, Hansen J, Timbol J, Lewis N, Isturiz R, Alexander-Parrish R, McLaughlin JM, Gessner BD, Klein NP. Incidence and Estimated Vaccine Effectiveness Against Hospitalizations for All-Cause Pneumonia Among Older US Adults Who Were Vaccinated and Not Vaccinated With 13-Valent Pneumococcal Conjugate Vaccine. JAMA network open. 2022 Mar 1:5(3):e221111. doi: 10.1001/jamanetworkopen.2022.1111. Epub 2022 Mar 1     [PubMed PMID: 35302634]

[149]

Jones B, Waterer G. Advances in community-acquired pneumonia. Therapeutic advances in infectious disease. 2020 Jan-Dec:7():2049936120969607. doi: 10.1177/2049936120969607. Epub 2020 Nov 6     [PubMed PMID: 33224494]

[150]

Rose MA, Barker M, Liese J, Adams O, Ankermann T, Baumann U, Brinkmann F, Bruns R, Dahlheim M, Ewig S, Forster J, Hofmann G, Kemen C, Lück C, Nadal D, Nüßlein T, Regamey N, Riedler J, Schmidt S, Schwerk N, Seidenberg J, Tenenbaum T, Trapp S, van der Linden M. [Guidelines for the Management of Community Acquired Pneumonia in Children and Adolescents (Pediatric Community Acquired Pneumonia, pCAP) - Issued under the Responsibility of the German Society for Pediatric Infectious Diseases (DGPI) and the German Society for Pediatric Pulmonology (GPP)]. Pneumologie (Stuttgart, Germany). 2020 Aug:74(8):515-544. doi: 10.1055/a-1139-5132. Epub 2020 Aug 21     [PubMed PMID: 32823360]

[151]

Baskaran V, Pearce F, Harwood RH, McKeever TM, Lim WS. Primary care consultations after hospitalisation for pneumonia: a large population-based cohort study. The British journal of general practice : the journal of the Royal College of General Practitioners. 2021 Apr:71(705):e250-e257. doi: 10.3399/BJGP.2020.0890. Epub 2021 Mar 26     [PubMed PMID: 33753348]

[152]

Hooper L, Abdelhamid A, Ajabnoor SM, Esio-Bassey C, Brainard J, Brown TJ, Bunn D, Foster E, Hammer CC, Hanson S, Jimoh FO, Maimouni H, Sandhu M, Wang X, Winstanley L, Cross JL, Welch AA, Rees K, Philpott C. Effects of fluid and drinking on pneumonia mortality in older adults: A systematic review and meta-analysis. Clinical nutrition ESPEN. 2022 Feb:47():96-105. doi: 10.1016/j.clnesp.2021.11.021. Epub 2021 Nov 19     [PubMed PMID: 35063249]

[153]

Bott J, Blumenthal S, Buxton M, Ellum S, Falconer C, Garrod R, Harvey A, Hughes T, Lincoln M, Mikelsons C, Potter C, Pryor J, Rimington L, Sinfield F, Thompson C, Vaughn P, White J, British Thoracic Society Physiotherapy Guideline Development Group. Guidelines for the physiotherapy management of the adult, medical, spontaneously breathing patient. Thorax. 2009 May:64 Suppl 1():i1-51. doi: 10.1136/thx.2008.110726. Epub     [PubMed PMID: 19406863]

[154]

Meli A, Barbeta Viñas E, Battaglini D, Li Bassi G, Yang H, Yang M, Bobi J, Motos A, Fernández-Barat L, Chiumello D, Pelosi P, Torres A. Lateral position during severe mono-lateral pneumonia: an experimental study. Scientific reports. 2020 Nov 9:10(1):19372. doi: 10.1038/s41598-020-76216-w. Epub 2020 Nov 9     [PubMed PMID: 33168922]

[155]

Sud S, Friedrich JO, Taccone P, Polli F, Adhikari NK, Latini R, Pesenti A, Guérin C, Mancebo J, Curley MA, Fernandez R, Chan MC, Beuret P, Voggenreiter G, Sud M, Tognoni G, Gattinoni L. Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis. Intensive care medicine. 2010 Apr:36(4):585-99. doi: 10.1007/s00134-009-1748-1. Epub 2010 Feb 4     [PubMed PMID: 20130832]

[156]

Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogué S, Ferrer M. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet (London, England). 1999 Nov 27:354(9193):1851-8     [PubMed PMID: 10584721]

[157]

Kaye KS, Stalam M, Shershen WE, Kaye D. Utility of pulse oximetry in diagnosing pneumonia in nursing home residents. The American journal of the medical sciences. 2002 Nov:324(5):237-42     [PubMed PMID: 12449443]

[158]

Liaqat A, Mason M, Foster BJ, Kulkarni S, Barlas A, Farooq AM, Patak P, Liaqat H, Basso RG, Zaman MS, Pau D. Evidence-Based Mechanical Ventilatory Strategies in ARDS. Journal of clinical medicine. 2022 Jan 10:11(2):. doi: 10.3390/jcm11020319. Epub 2022 Jan 10     [PubMed PMID: 35054013]

[159]

Tang W, Shao X, Chen Q, Zhu L, He Y, Lu E. Nutritional status of protein intake in severe pneumonia patients based on dietary nutrition information system. Journal of infection and public health. 2021 Jan:14(1):66-70. doi: 10.1016/j.jiph.2019.07.016. Epub 2019 Aug 14     [PubMed PMID: 31422039]

[160]

Ito A, Ishida T, Tokumasu H, Washio Y, Yamazaki A, Ito Y, Tachibana H. Prognostic factors in hospitalized community-acquired pneumonia: a retrospective study of a prospective observational cohort. BMC pulmonary medicine. 2017 May 2:17(1):78. doi: 10.1186/s12890-017-0424-4. Epub 2017 May 2     [PubMed PMID: 28464807]

[161]

Mbata G, Chukwuka C, Onyedum C, Onwubere B, Aguwa E. The role of complications of community acquired pneumonia on the outcome of the illness: a prospective observational study in a tertiary institution in eastern Nigeria. Annals of medical and health sciences research. 2013 Jul:3(3):365-9. doi: 10.4103/2141-9248.117952. Epub     [PubMed PMID: 24116315]

[162]

Hespanhol V, Bárbara C. Pneumonia mortality, comorbidities matter? Pulmonology. 2020 May-Jun:26(3):123-129. doi: 10.1016/j.pulmoe.2019.10.003. Epub 2019 Nov 29     [PubMed PMID: 31787563]

[163]

Ruiz LA, España PP, Gómez A, Bilbao A, Jaca C, Arámburu A, Capelastegui A, Restrepo MI, Zalacain R. Age-related differences in management and outcomes in hospitalized healthy and well-functioning bacteremic pneumococcal pneumonia patients: a cohort study. BMC geriatrics. 2017 Jun 20:17(1):130. doi: 10.1186/s12877-017-0518-0. Epub 2017 Jun 20     [PubMed PMID: 28633626]

[164]

Cillóniz C, Ewig S, Polverino E, Marcos MA, Esquinas C, Gabarrús A, Mensa J, Torres A. Microbial aetiology of community-acquired pneumonia and its relation to severity. Thorax. 2011 Apr:66(4):340-6. doi: 10.1136/thx.2010.143982. Epub 2011 Jan 21     [PubMed PMID: 21257985]

[165]

Poovieng J, Sakboonyarat B, Nasomsong W. Bacterial etiology and mortality rate in community-acquired pneumonia, healthcare-associated pneumonia and hospital-acquired pneumonia in Thai university hospital. Scientific reports. 2022 May 30:12(1):9004. doi: 10.1038/s41598-022-12904-z. Epub 2022 May 30     [PubMed PMID: 35637232]

[166]

Vlaeminck J, Raafat D, Surmann K, Timbermont L, Normann N, Sellman B, van Wamel WJB, Malhotra-Kumar S. Exploring Virulence Factors and Alternative Therapies against Staphylococcus aureus Pneumonia. Toxins. 2020 Nov 18:12(11):. doi: 10.3390/toxins12110721. Epub 2020 Nov 18     [PubMed PMID: 33218049]

[167]

Liao C, Huang X, Wang Q, Yao D, Lu W. Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance. Frontiers in cellular and infection microbiology. 2022:12():926758. doi: 10.3389/fcimb.2022.926758. Epub 2022 Jul 6     [PubMed PMID: 35873152]

[168]

Fine MJ, Smith MA, Carson CA, Mutha SS, Sankey SS, Weissfeld LA, Kapoor WN. Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis. JAMA. 1996 Jan 10:275(2):134-41     [PubMed PMID: 8531309]

[169]

Li JS, Hou ZK, Yu XQ, Li SY, Sun ZK, Zhang W, Jia XH, Zheng SP, Wang MH, Wang HF. Prognostic factors for community-acquired pneumonia in middle-aged and elderly patients treated with integrated medicine. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2012 Jun:32(2):179-86     [PubMed PMID: 22876440]

[170]

Hoogewerf M, Oosterheert JJ, Hak E, Hoepelman IM, Bonten MJ. Prognostic factors for early clinical failure in patients with severe community-acquired pneumonia. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2006 Nov:12(11):1097-104     [PubMed PMID: 17002609]

[171]

Karakuzu Z, Iscimen R, Akalin H, Kelebek Girgin N, Kahveci F, Sinirtas M. Prognostic Risk Factors in Ventilator-Associated Pneumonia. Medical science monitor : international medical journal of experimental and clinical research. 2018 Mar 5:24():1321-1328     [PubMed PMID: 29503436]

[172]

Barnes CE, MacIntyre CR. Risk modelling the mortality impact of antimicrobial resistance in secondary pneumococcal pneumonia infections during the 2009 influenza pandemic. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2019 Aug:85():1-6. doi: 10.1016/j.ijid.2019.05.005. Epub 2019 May 13     [PubMed PMID: 31096052]

[173]

Scott H, Zahra A, Fernandes R, Fries BC, Thode HC Jr, Singer AJ. Bacterial infections and death among patients with Covid-19 versus non Covid-19 patients with pneumonia. The American journal of emergency medicine. 2022 Jan:51():1-5. doi: 10.1016/j.ajem.2021.09.040. Epub 2021 Sep 28     [PubMed PMID: 34637995]

[174]

Azuma Y. [Pharmacological studies on rat passive cutaneous anaphylaxis (PCA) (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1980 Nov:76(8):685-96     [PubMed PMID: 6168549]

[175]

Finch RG. Pneumonia: the impact of antibiotic resistance on its management. Microbial drug resistance (Larchmont, N.Y.). 1995 Summer:1(2):149-58     [PubMed PMID: 9158749]

[176]

Chen HH, Stringer A, Eguale T, Rao GG, Ozawa S. Impact of Antibiotic Resistance on Treatment of Pneumococcal Disease in Ethiopia: An Agent-Based Modeling Simulation. The American journal of tropical medicine and hygiene. 2019 Nov:101(5):1042-1053. doi: 10.4269/ajtmh.18-0930. Epub     [PubMed PMID: 31516111]

[177]

Hsu JL, Siroka AM, Smith MW, Holodniy M, Meduri GU. One-year outcomes of community-acquired and healthcare-associated pneumonia in the Veterans Affairs Healthcare System. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2011 Jun:15(6):e382-7. doi: 10.1016/j.ijid.2011.02.002. Epub 2011 Mar 9     [PubMed PMID: 21393043]

[178]

Mortensen EM, Kapoor WN, Chang CC, Fine MJ. Assessment of mortality after long-term follow-up of patients with community-acquired pneumonia. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2003 Dec 15:37(12):1617-24     [PubMed PMID: 14689342]

[179]

Garcia-Vidal C, Ardanuy C, Tubau F, Viasus D, Dorca J, Liñares J, Gudiol F, Carratalà J. Pneumococcal pneumonia presenting with septic shock: host- and pathogen-related factors and outcomes. Thorax. 2010 Jan:65(1):77-81. doi: 10.1136/thx.2009.123612. Epub 2009 Dec 8     [PubMed PMID: 19996337]

[180]

Kurahashi K, Kajikawa O, Sawa T, Ohara M, Gropper MA, Frank DW, Martin TR, Wiener-Kronish JP. Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia. The Journal of clinical investigation. 1999 Sep:104(6):743-50     [PubMed PMID: 10491409]

[181]

Bodmann KF. Current guidelines for the treatment of severe pneumonia and sepsis. Chemotherapy. 2005 Aug:51(5):227-33     [PubMed PMID: 16103664]

[182]

Tsai YF, Ku YH. Necrotizing pneumonia: a rare complication of pneumonia requiring special consideration. Current opinion in pulmonary medicine. 2012 May:18(3):246-52. doi: 10.1097/MCP.0b013e3283521022. Epub     [PubMed PMID: 22388585]

[183]

Wallace WA, Fitch PM, Simpson AJ, Howie SE. Inflammation-associated remodelling and fibrosis in the lung - a process and an end point. International journal of experimental pathology. 2007 Apr:88(2):103-10     [PubMed PMID: 17408453]

[184]

McCauley L, Dean N. Pneumonia and empyema: causal, casual or unknown. Journal of thoracic disease. 2015 Jun:7(6):992-8. doi: 10.3978/j.issn.2072-1439.2015.04.36. Epub     [PubMed PMID: 26150912]

[185]

Kastenbauer S, Pfister HW. Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases. Brain : a journal of neurology. 2003 May:126(Pt 5):1015-25     [PubMed PMID: 12690042]

[186]

de Roux A, Cavalcanti M, Marcos MA, Garcia E, Ewig S, Mensa J, Torres A. Impact of alcohol abuse in the etiology and severity of community-acquired pneumonia. Chest. 2006 May:129(5):1219-25     [PubMed PMID: 16685012]

[187]

Son M, Jo S, Lee JS, Lee DH. Association between oral health and incidence of pneumonia: a population-based cohort study from Korea. Scientific reports. 2020 Jun 12:10(1):9576. doi: 10.1038/s41598-020-66312-2. Epub 2020 Jun 12     [PubMed PMID: 32533077]

[188]

Rabie T, Curtis V. Handwashing and risk of respiratory infections: a quantitative systematic review. Tropical medicine & international health : TM & IH. 2006 Mar:11(3):258-67     [PubMed PMID: 16553905]

[189]

Tessmer A, Welte T, Schmidt-Ott R, Eberle S, Barten G, Suttorp N, Schaberg T, CAPNETZ study group. Influenza vaccination is associated with reduced severity of community-acquired pneumonia. The European respiratory journal. 2011 Jul:38(1):147-53. doi: 10.1183/09031936.00133510. Epub 2010 Dec 9     [PubMed PMID: 21148226]

[190]

Ramírez JA. Processes of care for community-acquired pneumonia. Infectious disease clinics of North America. 2004 Dec:18(4):843-59     [PubMed PMID: 15555828]

[191]

Bruns AH, Oosterheert JJ, El Moussaoui R, Opmeer BC, Hoepelman AI, Prins JM. Pneumonia recovery: discrepancies in perspectives of the radiologist, physician and patient. Journal of general internal medicine. 2010 Mar:25(3):203-6. doi: 10.1007/s11606-009-1182-7. Epub 2009 Dec 5     [PubMed PMID: 19967464]

[192]

Mittl RL Jr, Schwab RJ, Duchin JS, Goin JE, Albeida SM, Miller WT. Radiographic resolution of community-acquired pneumonia. American journal of respiratory and critical care medicine. 1994 Mar:149(3 Pt 1):630-5     [PubMed PMID: 8118630]

[193]

Kaye J, Ashline V, Erickson D, Zeiler K, Gavigan D, Gannon L, Wynne P, Cooper J, Kittle W, Sharma K, Morton J. Critical care bug team: a multidisciplinary team approach to reducing ventilator-associated pneumonia. American journal of infection control. 2000 Apr:28(2):197-201     [PubMed PMID: 10760228]

[194]

Botwright S, Sutawong J, Kingkaew P, Anothaisintawee T, Dabak SV, Suwanpanich C, Promchit N, Kampang R, Isaranuwatchai W. Which interventions for alcohol use should be included in a universal healthcare benefit package? An umbrella review of targeted interventions to address harmful drinking and dependence. BMC public health. 2023 Feb 23:23(1):382. doi: 10.1186/s12889-023-15152-6. Epub 2023 Feb 23     [PubMed PMID: 36823618]

[195]

Hama K, Iwasa Y, Ohara Y, Iwasaki M, Ito K, Nakajima J, Matsushita T, Tohara T, Sakamoto M, Itoda M, Inohara K, Ozaki Y, Sasaki R, Nishi Y, Tsuneishi M, Furuya J, Watanabe Y, Watanabe Y, Sato Y, Yoshida M. Pneumonia incidence and oral health management by dental hygienists in long-term care facilities: A 1-year prospective multicentre cohort study. Gerodontology. 2022 Dec:39(4):374-383. doi: 10.1111/ger.12604. Epub 2021 Nov 9     [PubMed PMID: 34750855]

[196]

Viasus D, Vecino-Moreno M, De La Hoz JM, Carratalà J. Antibiotic stewardship in community-acquired pneumonia. Expert review of anti-infective therapy. 2017 Apr:15(4):351-359. doi: 10.1080/14787210.2017.1274232. Epub 2016 Dec 27     [PubMed PMID: 28002979]

[197]

Leone R, Moretti U, D'Incau P, Conforti A, Magro L, Lora R, Velo G. Effect of pharmacist involvement on patient reporting of adverse drug reactions: first Italian study. Drug safety. 2013 Apr:36(4):267-76. doi: 10.1007/s40264-013-0028-8. Epub     [PubMed PMID: 23475583]

[198]

Firman P, Tan KS, Clavarino A, Taing MW, Whitfield K. Pharmacist-Managed Therapeutic Drug Monitoring Programs within Australian Hospital and Health Services-A National Survey of Current Practice. Pharmacy (Basel, Switzerland). 2022 Oct 18:10(5):. doi: 10.3390/pharmacy10050135. Epub 2022 Oct 18     [PubMed PMID: 36287457]

[199]

Osti C, Wosti D, Pandey B, Zhao Q. Ventilator-Associated Pneumonia and Role of Nurses in Its Prevention. JNMA; journal of the Nepal Medical Association. 2017 Oct-Dec:56(208):461-8     [PubMed PMID: 29453481]

[200]

Chan SS, Leung DY, Leung AY, Lam C, Hung I, Chu D, Chan CK, Johnston J, Liu SH, Liang R, Lam TH, Yuen KY. A nurse-delivered brief health education intervention to improve pneumococcal vaccination rate among older patients with chronic diseases: a cluster randomized controlled trial. International journal of nursing studies. 2015 Jan:52(1):317-24. doi: 10.1016/j.ijnurstu.2014.06.008. Epub 2014 Jun 19     [PubMed PMID: 25012957]