Sphenopalatine Ganglion Block

Earn CME/CE in your profession:

Continuing Education Activity

The sphenopalatine ganglion is an extracranial parasympathetic ganglion found within the pterygopalatine fossa of the skull. Since it was first described in the early 1900s, clinical studies have since further characterized the role of sphenopalatine ganglion blockade in the treatment of a number of chronic, painful conditions. This activity discusses the indications and techniques for performing sphenopalatine ganglion blockade as well as reviews the anatomy of the sphenopalatine ganglion.


  • Describe the anatomy of the sphenopalatine ganglion.
  • Summarize the indications for performing a sphenopalatine ganglion block.
  • Outline the techniques commonly utilized to perform a sphenopalatine ganglion block.
  • Explain the importance of collaboration and communication among the interprofessional team members to ensure appropriate selection of candidates for sphenopalatine ganglion block and to enhance patient outcomes.


The role of the sphenopalatine ganglion (SPG) in the pathogenesis of pain and its use was first described as sphenopalatine neuralgia by Sluder in 1908. He described sphenopalatine neuralgia as a unilateral facial pain symptom complex with associated neuralgic, motor, sensory, and gustatory manifestations. Today, blockade of the sphenopalatine ganglion is utilized to treat a number of painful conditions.[1]

Anatomy and Physiology

The sphenopalatine ganglion (SPG) is an extracranial parasympathetic ganglion located within the pterygopalatine fossa. The borders of the pterygopalatine fossa are as follows: (1) anterior border - posterior wall of the maxillary sinus, (2) posterior border - medial pterygoid plate, (3) superior border - sphenoid sinus, (4) medial border - a perpendicular plate of the palatine bone, and (5) lateral border - communicates with the infratemporal fossa. It lies posterior to the middle nasal turbinate and maxillary sinus, forming multiple autonomic, sensory, and motor neural connections.[2]

Sensory Innervation

The maxillary branch of the trigeminal nerve passes through the foramen rotundum, which is located along the superolateral aspect of the pterygopalatine fossa. The SPG is “suspended” from the maxillary nerve via the pterygopalatine nerves. Sensory fibers arising from the maxillary nerve travel through the SPG, providing sensory innervation to the nasal membranes, soft palate, and parts of the pharynx.[3] 

Autonomic Innervation

Sympathetic innervation through the SPG originates from preganglionic sympathetic fibers in the upper thoracic spine, which course through the sympathetic chain and synapse with postganglionic fibers in the superior cervical sympathetic ganglion. Postganglionic fibers join the carotid nerves, then branch off and travel through the deep petrosal and vidian nerves. These postganglionic fibers course through the SPG to the lacrimal gland, nasal mucosa, and palatine mucosa. Parasympathetic innervation through the SPG originates in the superior salivatory nucleus in the pons. Parasympathetic fibers run in the nervus intermedius, which is a branch of the facial nerve, through the geniculate ganglion to form the greater petrosal nerve (GPN). Parasympathetic fibers synapse in the SPG. Second-order neurons then provide a secretomotor function to the nasal, oral, and pharyngeal mucous membranes, the lacrimal glands, and branches to the meningeal and cerebral blood vessels.[4]

The postganglionic sympathetic fibers projecting from the superior cervical ganglion give rise to the deep petrosal nerve. The vidian nerve is formed when the deep petrosal nerve joins the GPN before passing through the pterygoid canal located near the inferomedial portion of the fossa. 

The SPG itself gives off efferent branches to form the superior posterior lateral nasal and pharyngeal nerves. The SPG has direct connections with the greater and lesser palatine nerves. 


The use of the sphenopalatine ganglion block has been proposed as a treatment option for a variety of pain syndromes. Ho et al. evaluated the level of evidence for the use of SPGB in various pain syndromes utilizing the Oxford Center for Evidence-based Medicine scale:

(1a) Systematic review/meta-analysis of randomized controlled studies (1b) Single, well designed, randomized controlled trials with a narrow confidence interval(2a) Systematic review/meta-analysis of cohort studies(2b) Single cohort studies or randomized control studies of low quality(3a) Systemic review/meta-analysis of case-control studies(3b) Single case-control studies(4) Case series, as well as cohort and case-control studies of poor quality (5) Expert opinion

Grades of recommendation are as follows: (A) Level 1 studies with consistent results(B) Deduction from level 1 studies, or level 2 or 3 studies with consistent results(C) Level 4 studies, or deduction from level 2 or 3 studies(D) Level 5 evidence, or inconclusive/inconsistent results in the literature[5]

Indications for SPGB based on the highest level of evidence and grade of recommendation are as follows:

  1. Cluster headache: 2b, B
  2. Second-division trigeminal neuralgia: 2b, B
  3. To help reduce the need for analgesics after endoscopic sinus surgery: 1b, B
  4. Migraine headache: 2b, B

Due to a lack of controlled studies, the following proposed indications received a level of evidence of 4, grade C: headache syndromes including hemicrania continua, trigeminal neuralgia, and dural puncture headache. SPGB has level 4, grade C evidence for additional conditions including intractable hiccups, complex regional pain syndrome (CRPS), intercostal neuralgia, and dysmenorrhea.[5]


Contraindications to sphenopalatine ganglion block include allergy to any of the medications used, anticoagulation, history of facial trauma, infection, and patient refusal.


The pharmacologic agents frequently used for sphenopalatine ganglion block are local anesthetics (4% cocaine, 2% to 4% lidocaine, or 0.5% bupivacaine), depot steroids, or 6% phenol.[2][5] 

For the intranasal approach, a cotton tip applicator or catheter is needed. There are 3 approved SPGB devices. There is a void in the literature regarding the efficacy and tolerability of the two of them. These catheters are both inserted along the anterior nasal passage and are placed superior to the middle nasal turbinate.[3] They are comprised of a flexible sheath with an inner, extendible catheter with a curved tip.[3] The Tx360 device is inserted and advanced inferior to the middle nasal turbinate.[3][6][7] The catheter tip is positioned medial, inferior, and posterior to the target mucosa.[8] The opening of the catheter tip is designed to direct anesthetic in a superior, lateral, and anterior direction.[8]

For the infra-zygomatic approach, a 10 cm curved blunt 20 or 22 gauge needle is preferred. Alternatively, a 22 or 25 gauge 3.5-inch short-bevel needle with the distal tip bent to a 15-degree angle may be used. Additionally, a C-arm and 0.5 to 1 mL of nonionic, water-soluble contrast are needed.

The transoral approach requires a curved dental needle.


Preoperatively, it is imperative to note if the patient is on anticoagulant or antiplatelet therapy. If the patient is on anticoagulants or antiplatelet therapy, it may be necessary to communicate with the patient’s primary care physician (PCP) or cardiologist to ensure patient safety. In accordance with the PCP’s or cardiologist’s recommendations, agents such as warfarin, heparin, and factor 10a inhibitors should be held. A prothrombin time (PT) should be obtained preoperatively in patients on warfarin. A partial thromboplastin time (PTT) should be obtained preoperatively for heparin use.

On the day of the procedure, blood pressure and heart rate should be checked pre-and post-procedure. The patient should be placed in the supine position with the cervical spine extended. The nare(s) should be inspected for potential causes of obstruction such as a deviated septum or neoplasm.[3]


Sphenopalatine ganglion block can be performed through transnasal, transoral, or transcutaneous approaches.

Transnasal Topical Approach

  1. The patient is placed in the supine position with the cervical spine extended.
  2. The measurement of the distance from the opening of the nares to the mandibular notch directly below the zygoma can be used to estimate the depth of cotton-tipped applicator advancement needed.
  3. The cotton-tipped applicator is soaked in local anesthetic (viscous lidocaine 4%)
  4. The cotton-tipped applicator is advanced into the nares parallel to the zygoma with the tip angled laterally until it lays on the nasopharyngeal mucosa posterior to the middle nasal turbinate.
  5. A second applicator may be placed slightly posterior and superior to the initial applicator.
  6. A response is typically seen in 5 to 10 minutes. However, the applicator(s) may be left in position for 30 minutes.

Transnasal Injection Approach

  1. The patient is placed in the supine position with the cervical spine extended.
  2. A cotton-tipped applicator soaked in local anesthetic is advanced along the superior border of the middle turbinate. It is stopped when the posterior wall of the nasopharynx is reached. Alternatively, a small about of viscous lidocaine can be instilled into the nare(s), after which the patient inhales briskly to draw the lidocaine toward the posterior nasopharynx.
  3. The chosen SPGB device (The SphenoCath, Allevio SPG Nerve Block Catheter, or Tx360 Nasal Injector) is then advanced into the ipsilateral nare.
  4. Contrast can be injected under fluoroscopy to visualize needle tip placement.
  5. Once the catheter tip is in place, the inner catheter is advanced to administer local anesthetic.
  6. The patient should be instructed to remain in the same position for 10 minutes.[5][9][10]

Advantages: Simplest technique, short procedure time, low risk with complications limited to epistaxis and infection

Disadvantages: It requires the diffusion of local anesthetic across mucous membranes.[2][11]

Transoral Approach

A curved dental needle passes through the greater palatine foramen (GPF) in the posterior portion of the hard palate. This should be just medial to the gum line opposite the third molar tooth to reach the superior aspect of the pterygopalatine fossa.

Advantages: Provides more direct access to the sphenopalatine ganglia.

Disadvantages: Needle-based invasive approach, technically challenging, exhibits the greatest complications, most patient discomfort, and unpredictable with regards to ensuring proper anesthetic placement.[11][2]

Infrazygomatic Approach

Fluoroscopy or computed tomography (CT) is recommended for patient safety and improved chance of direct delivery of local anesthetic to the SPG.

  1. The patient is placed in the supine position.
  2. Apply sterile prepping and drape to the appropriate side of the face
  3. Obtain a lateral fluoroscopic view of the face using a C-arm by superimposing the mandibular rami on top of one another
  4. Anesthetize the skin above the mandibular notch
  5. A 10 cm curved blunt 20 or 22 gauge needle is preferred. Alternatively, a 22 or 25 gauge 3.5-inch short-bevel needle with the distal tip bent to a 15-degree angle may be used.
  6. Advance the needle in a superior and medial direction toward the pterygopalatine fossa under fluoroscopy.
  7. An intermittent anteroposterior (AP) view should be obtained to assess needle depth.
  8. Needle tip advancement should terminate immediately adjacent to the ipsilateral nasal wall.
  9. 0.5-1 mL of nonionic, water-soluble contrast should be injected under continuous fluoroscopy to rule out intravascular uptake and intranasal spread.
  10. Once proper needle placement is confirmed, 1 to 2 mL of local anesthetics, such as 1 to 2% lidocaine or 0.25% bupivacaine with or without corticosteroids, is injected.

Advantages: Needle-based invasive approach and use of fluoroscopy allow for direct administration of a local anesthetic to the SPG

Disadvantages: CT guidance requires greater radiation exposure to the patient, more invasive.[11]


Minor adverse effects of sphenopalatine ganglion block are typically local and include epistaxis, transient anesthesia, or hypoesthesia of the root of the nose, pharynx, and palate and lacrimation of ipsilateral eye. Major adverse effects are uncommon but can include infection in the setting of improper aseptic technique, local or retroorbital hematoma.[2][5]

Clinical Significance

The sphenopalatine ganglion block is used for a variety of headache and facial pain syndromes and has variable efficacy depending on the disease process treated. Significant reduction in pain is meaningful when followed by an increase in functional capacity, reduction in health care use, and/or reduction in opioid use. If the SPGB works for a short duration of time, it can be followed by radiofrequency neurotomy or SPG stimulation to increase the duration of pain relief. Therefore, it can serve as a diagnostic block and is commonly used for this purpose.[12]

Enhancing Healthcare Team Outcomes

Chronic headache and facial pain syndromes can lead to significant disability, decreased functionality, and an increase in healthcare costs. An interprofessional approach to these patients is most effective and involves management by neurology, psychology, as well as pain management.

Diagnosis and appropriate patient selection for sphenopalatine ganglion blockade are essential. The role of identifying appropriate candidates for the procedure is generally fulfilled by neurologists and headache specialists. Additionally, the mental health implications of living with chronic pain must be considered, as well. In these patients, psychological screening is appropriate. When needed, a referral to a pain psychologist for additional support is prudent. Moreover, nursing providers play an important role during the performance of a sphenopalatine ganglion block by helping ensure patient comfort and aiding in monitoring for adverse events. Adverse events should be properly documented by the treating provider.

Article Details

Article Author

Christopher Alexander

Article Editor:

Anterpreet Dua


5/4/2021 2:56:41 PM



Ahamed SH,Jones NS, What is Sluder's neuralgia? The Journal of laryngology and otology. 2003 Jun;     [PubMed PMID: 12818050]


Piagkou M,Demesticha T,Troupis T,Vlasis K,Skandalakis P,Makri A,Mazarakis A,Lappas D,Piagkos G,Johnson EO, The pterygopalatine ganglion and its role in various pain syndromes: from anatomy to clinical practice. Pain practice : the official journal of World Institute of Pain. 2012 Jun;     [PubMed PMID: 21956040]


Robbins MS,Robertson CE,Kaplan E,Ailani J,Charleston L 4th,Kuruvilla D,Blumenfeld A,Berliner R,Rosen NL,Duarte R,Vidwan J,Halker RB,Gill N,Ashkenazi A, The Sphenopalatine Ganglion: Anatomy, Pathophysiology, and Therapeutic Targeting in Headache. Headache. 2016 Feb;     [PubMed PMID: 26615983]


Binfalah M,Alghawi E,Shosha E,Alhilly A,Bakhiet M, Sphenopalatine Ganglion Block for the Treatment of Acute Migraine Headache. Pain research and treatment. 2018;     [PubMed PMID: 29862074]


Ho KWD,Przkora R,Kumar S, Sphenopalatine ganglion: block, radiofrequency ablation and neurostimulation - a systematic review. The journal of headache and pain. 2017 Dec 28;     [PubMed PMID: 29285576]


Cady R,Saper J,Dexter K,Manley HR, A double-blind, placebo-controlled study of repetitive transnasal sphenopalatine ganglion blockade with tx360(®) as acute treatment for chronic migraine. Headache. 2015 Jan;     [PubMed PMID: 25338927]


Cady RK,Saper J,Dexter K,Cady RJ,Manley HR, Long-term efficacy of a double-blind, placebo-controlled, randomized study for repetitive sphenopalatine blockade with bupivacaine vs. saline with the Tx360 device for treatment of chronic migraine. Headache. 2015 Apr;     [PubMed PMID: 25828648]


Candido KD,Massey ST,Sauer R,Darabad RR,Knezevic NN, A novel revision to the classical transnasal topical sphenopalatine ganglion block for the treatment of headache and facial pain. Pain physician. 2013 Nov-Dec;     [PubMed PMID: 24284858]


Yang lY,Oraee S, A novel approach to transnasal sphenopalatine ganglion injection. Pain physician. 2006 Apr;     [PubMed PMID: 16703973]


Windsor RE,Jahnke S, Sphenopalatine ganglion blockade: a review and proposed modification of the transnasal technique. Pain physician. 2004 Apr;     [PubMed PMID: 16868606]


Tolba R,Weiss AL,Denis DJ, Sphenopalatine Ganglion Block and Radiofrequency Ablation: Technical Notes and Efficacy. The Ochsner journal. 2019 Spring;     [PubMed PMID: 30983899]


Kaye AD,Motejunas MW,Cornett EM,Ehrhardt KP,Novitch MB,Class J,Siddaiah H,Hart BM,Urman RD, Emerging Novel Pharmacological Non-opioid Therapies in Headache Management: a Comprehensive Review. Current pain and headache reports. 2019 Jul 8;     [PubMed PMID: 31286276]