Coronary Sinus Thrombosis

Earn CME/CE in your profession:

Continuing Education Activity

The coronary venous system generally receives minimal attention in the medical literature. Even though the coronary sinus is a major access site for many invasive cardiology procedures, healthcare professionals rarely encounter diseases related to the coronary venous system. The exception is congenital malformations. Coronary sinus thrombosis is a rare and severe condition that is usually a post-procedural complication following invasive right heart instrumentation. Sometimes the condition occurs spontaneously. This activity reviews the pathophysiology of coronary sinus thrombosis and highlights the role of the interprofessional team in its management.


  • Identify the etiology of coronary sinus thrombosis
  • Review the presentation of coronary sinus thrombosis.
  • Describe the treatment and management options available for coronary sinus thrombosis.
  • Explain interprofessional team strategies for improving care coordination and communication to advance the treatment of coronary sinus thrombosis and improve outcomes.


The coronary venous system generally receives minimal attention in the medical literature. Even though the coronary sinus is major access site for many invasive cardiology procedures, healthcare professionals rarely encounter diseases related to the coronary venous system. The exception is congenital malformations. Coronary sinus thrombosis is a rare and severe condition that is usually a post-procedural complication following invasive right heart instrumentation[1]. Sometimes the condition occurs spontaneously.


Similar to thrombosis at any other sites, coronary sinus thrombosis results from a combination of venous stasis, alteration of the coagulation profile, and vessel wall injury, for example, endothelial damage.

The following invasive right heart procedures have all been implicated in the etiology and pathogenesis of coronary sinus thrombosis[1][2][3][4][5][6][7][8][9].

  • Central venous catheter placement
  • Coronary sinus instrumentation for ventricular lead placement during cardiac resynchronization
  • Coronary sinus cannulation for retrograde cardioplegia during cardiopulmonary bypass for cardiac surgery (such as heart transplantation, mitral valve replacement)
  • Bi-ventricular defibrillator placement in severe cardiomyopathy, 
  • Electrophysiologic ablations for arrhythmias such as supraventricular tachycardias
  • Ventriculoatrial shunt insertion for hydrocephalus

The common factor in the etiopathogenesis of all of these cases has been endothelial injury leading to thrombosis.

Spontaneous non-iatrogenic coronary sinus thrombosis cases that do not involve endothelial injury, but rather involve either venous stasis or alteration in coagulation profile have been documented in association with preexisting disease processes including[10][11][12][13]:

  • Atrial fibrillation
  • Right heart failure
  • Tricuspid regurgitation
  • Chronic obstructive pulmonary disease
  • Chronic cor pulmonale due to pulmonary fibrosis
  • Kawasaki disease
  • Acute lymphoblastic leukemia

It has been documented as a complication of infective endocarditis as well, specifically fungal endocarditis. Sepsis and disseminated coagulopathy play an additional role in precipitating spontaneous coronary sinus thrombosis. Embolic sequela of an intra-abdominal infectious process and recently, Crohn’s disease[11] is also reported to be associated with spontaneous coronary sinus thrombosis. Prior cases of coronary sinus thrombosis resulting from massive atrial thrombosis extending into the coronary sinus have also been reported.


The occurrence of coronary sinus thrombosis is rare, or at least rarely reported. However, out of the published cases, acute ones are substantially more common (more than 80) than chronic ones. Considering the high number of the patients who undergo ventricular pacing via the coronary sinus with ventricular pacemakers, the lack of reports of coronary sinus thrombosis is often surprising. Because ventricular pacemakers are usually implanted in reasonably sick patients with severe cardiomyopathy, sudden death is unlikely to be investigated with a postmortem study. In at least few of these, the possibility that thrombosis of the coronary sinus could be associated with cardiac death remains unanswered.

There is no clear male or female predominance reported. It is likely that coronary sinus thrombosis is under-recognized because of the rapid deterioration of these patients and limited overall clinical experience of cardiologists with this condition. Most acute cases are usually fatal and often diagnosed on autopsy, and this curtails the reported incidence and prevalence of this condition.


The venous drainage of the heart consists of 3 separate systems. See figure 1. The first major system is the coronary sinus which receives approximately 60% of the total cardiac venous return from posterior myocardium via several tributaries and opens into the right atrium. The second system consists of the anterior cardiac veins, which also opens into the right atrium and drains most of the remaining 40%. There are many anastomotic connections between these 2 systems.

Lastly, the heart is also drained by a third minor system the thebesian veins, consisting of many small veins, venae cordis minimae, that drain directly into all chambers of the heart. Sometimes the thebesian vessels can drain up to 50% of the total cardiac venous return. Therefore, considering these anastomotic connections between the coronary sinus and the anterior cardiac veins, and the drainage capability of the thebesian veins, coronary sinus thrombosis would, at least theoretically, appear to be a relatively benign entity, but it is not.

"Corona" means crown in Latin. Since this vessel forms a partial crown like circle around the heart, it is aptly named "Coronary." The length and diameter of the coronary sinus are variable. The overall size is affected by several factors such as volume status of the body, preload from the venous return, preexisting history of heart disease or heart surgery, amount of atrial myocardial tissue contributing to the vessel wall.

The coronary sinus is formed by a collection of veins joined together to form a large bore vessel, the coronary sinus, that collects blood from the heart muscle[14]. The coronary sinus has the following tributaries:

  • Great cardiac vein
  • Oblique vein of the left heart
  • Posterior vein of the left ventricle
  • Middle cardiac vein
  • Small cardiac vein

The mechanism involving coronary sinus thrombosis has been suspected to be similar to thrombosis at other sites, for example, endothelial damage, hypercoagulability, and venous stasis, a triad, proposed by Virchow in 1856. Previously described cases of coronary sinus thrombosis had involved each of these factors.

The most common mechanism for triggering thrombosis is endothelial damage during invasive cardiac procedures. In cases of spontaneous thrombosis, it is perhaps the chronic stasis, as in atrial fibrillation or hypercoagulable state, as in malignancy.

Acute coronary sinus occlusion causes abrupt elevation of the transcapillary pressure which, in turn, causes increased myocardial perfusion pressure even in the presence of normal healthy coronary arteries. In addition, the venous and capillary engorgement may directly result in direct myocardial injury. Both mechanisms may lead to a transudative effusion[15]. This rapid increase in myocardial perfusion pressure decreases coronary artery blood flow inducing ischemia, arrhythmia, progression to infarction, and sudden cardiac death.

Chronic nonocclusive coronary sinus thrombosis may not increase coronary venous pressures to the same degree but is at risk of embolization, extension into the right atrium, and fragmentation which may also embolize to the pulmonary artery, or to the systemic circulation in the presence of an atrial septal defect. Chronic progressive occlusion has also been described to be well tolerated, probably due to an efficient collateral circulation between the coronary sinus, anterior cardiac and Thebesian venous systems. On rare occasions, it could be asymptomatic without any signs of overt ischemia.

History and Physical

A high index of clinical suspicion is required to consider coronary sinus thrombosis in the diagnosis as the symptoms are not well characterized due to the shortage of published cases and relatively high mortality rate.

Early studies have shown that occlusion of the coronary sinus resulted in chest pain, shortness of breath, hypotension, ischemic electrocardiogram changes such as ST-segment elevations, pericardial effusion, cardiogenic shock, or even sudden cardiac death. Mortality is high due to the nonspecific clinical presentation, rapidity of clinical deterioration, and rarity of the condition[16][6].

Occasionally a few cases have an insidious onset and form a partial or incomplete thrombus. Such partial or incomplete occlusion of the coronary sinus by chronic thromboses may not cause immediate death due to the formation of adequate collateral circulation among coronary sinus, anterior cardiac vein, and Thebesain veins. Therefore chronic occlusion of the coronary sinus with thrombus remains silent without any signs of myocardial decompensation until further complications such as progression to complete occlusion or rupture and embolization of the thrombus develop causing potential pulmonary embolism or myocardial dysfunction or infarction.


The coronary sinus, if dilated, is seen on transthoracic echocardiography in parasternal long-axis view and apical 4-chamber view. It is even more reliably visualized on transesophageal echocardiography in a modified mid-esophageal 4-chamber view and the bi-caval view[17][14][18].

On the other hand, asymptomatic chronic coronary sinus thrombosis in patients is detected incidentally on a CT scan or angiography or routine echocardiography done for other purposes. In acute severe cases where sudden cardiac death results it is found on autopsy if one is done promptly. In the majority of deaths due to acute coronary sinus thrombosis, the antemortem diagnosis was not made due to lack of clinical suspicion, until autopsy findings of thrombosed coronary sinus were discovered.

Treatment / Management

Unfortunately, management of coronary sinus thrombosis is also poorly described. The role of aspirin is doubtful. Coronary sinus thrombectomy[13] in acutely ill patients followed by anticoagulation with heparin bridge to warfarin therapy has been utilized in both stable and unstable patients. Anticoagulation alone with low-molecular-weight heparin as a bridge to warfarin or novel oral anticoagulant therapy has also been employed in clinically stable patients.

Although healthcare professionals use the above treatment modalities with reasonable benefit, there is not enough literature to elucidate any mortality or morbidity benefit with such treatments. Clear, concise guidelines to facilitate management in the long run and the role of anticoagulation therapy especially novel oral anticoagulants require further clinical studies.

Differential Diagnosis

Due to non-specificity of the clinical presentation and limited experience with coronary sinus thrombosis, it is usually is not very high on the list of differentials. The following possible differential diagnoses need to be considered.

  1. Myocardial Infarction (MI): With a presentation of chest pain, dyspnea, hypotension, tachycardia, elevated troponins and ischemic changes on the ECG, MI due to coronary artery disease is high on the differential. Coronary sinus thrombosis can also present with a similar picture. However, a coronary angiogram can differentiate both conditions and diagnose coronary sinus thrombosis. Establishing a clear cause and diagnosis is critical as management of MI due to CAD is very different from MI due to Coronary sinus thrombosis.
  2. Pericardial effusion and tamponade: It is very pertinent to differentiate pericardial effusion due to coronary sinus thrombosis from pericardial effusion due to multiple other causes such as cancer, infection or autoimmune disorders, as again the management differs significantly according to the etiology.
  3. Septic shock: Acutely decompensated cases with coronary sinus thrombosis can present with a cardiogenic shock which has to be differentiated from septic shock. Clinical parameters like the source of infection, signs of sepsis, labs, and investigations pertaining to sepsis workup should help distinguish both conditions.
  4. An incidental dilated coronary sinus due to thrombosis has to be differentiated from other causes of coronary sinus dilation such as congenital disorders causing an abnormally increased venous return to the coronary sinus. These include patent left SVC, anomalous hepatic and pulmonary venous drainage, and coronary arteriovenous fistulae. A dilated coronary sinus can also be seen in right heart failure with ventricular dysfunction and conditions causing increased right atrial pressure such as pulmonary hypertension.


The prognosis is poor especially in acute presentations with more than 80% of patients developing devastating complications as mentioned earlier and resulting in cardiac death. However, asymptomatic patients with incidental diagnosis of chronic coronary sinus thrombosis are less reported than acute ones and prognosis is better on aggressive treatment with effective anticoagulation with or without thrombectomy.


As mentioned earlier coronary sinus thrombosis can have devastating fatal complications such as acute myocardial ischemia, myocardial infarction, pulmonary embolism, pericardial effusion, cardiac tamponade, cardiogenic shock, and even sudden cardiac death if early diagnosis and treatment is not initiated[7][9].


Due to the complex nature of the presentation of coronary sinus thrombosis, especially in acute presentations, critical care consultation is warranted. Also, cardiology and electrophysiology consultations would prove to be prudent if time and the patient's clinical presentations permit.

Pearls and Other Issues

Coronary sinus thrombosis is a rare but potentially deadly complication of many invasive cardiac procedures, many of which are performed on a daily basis such as central venous catheter placements or ventricular pacing. It may present with ST elevations on ECG, pericardial tamponade, and cardiogenic shock. Early recognition and immediate treatment of the thrombosed coronary sinus is critical if resuscitation is to be successful.

Enhancing Healthcare Team Outcomes

Coronary sinus thrombosis is best managed by an interprofessional team that includes pharmacists. Despite the known complications, there are no clear guidelines or recommendations to assist physicians in the long-term management of such patients. The role of anticoagulation remains unclear and warrants further investigation. A systematic study of the incidence and sequelae of coronary sinus thrombosis in patients who undergo manipulation of the coronary sinus is certainly warranted.

Case reports indicate poor outcomes in symptomatic patients.[19]

(Click Image to Enlarge)
Fig 1. Schematic diagram depicting coronary sinus of the heart and its tributaries.
Fig 1. Schematic diagram depicting coronary sinus of the heart and its tributaries.
Arunachalam K (2016) Coronary Sinus Anatomy and its Importance-evidence based Review. Anat Physiol 6:207. doi:10.4172/2161-0940.1000207 Source: Open access article. Coronary Sinus Anatomy and its Importance-evidence based Review. OMICS International. Author: Arunachalam K.
Article Details

Article Author

Wajeed Masood

Article Editor:

Kranthi K. Sitammagari


9/19/2022 12:00:53 PM



Coronary sinus thrombosis after cannulation during cardiopulmonary bypass., Bapat VN,Hardikar AA,Porwal MM,Agrawal NB,Tendolkar AG,, The Annals of thoracic surgery, 1996 Nov     [PubMed PMID: 8893593]


Management of catheter-related injuries to the coronary sinus., Economopoulos GC,Michalis A,Palatianos GM,Sarris GE,, The Annals of thoracic surgery, 2003 Jul     [PubMed PMID: 12842523]


Pericardial tamponade and coronary sinus thrombosis associated with central venus catheterization., Figuerola M,Tomás MT,Armengol J,Bejar A,Adrados M,Bonet A,, Chest, 1992 Apr     [PubMed PMID: 1555439]


Coronary sinus thrombus without spontaneous contrast., Floria M,Negru D,Antohe I,, Journal of thrombosis and thrombolysis, 2016 Oct     [PubMed PMID: 27116357]


Angiographic demonstration of coronary sinus thrombosis: a potential consequence of trauma to the coronary sinus., Hazan MB,Byrnes DA,Elmquist TH,Mazzara JT,, Catheterization and cardiovascular diagnosis, 1982     [PubMed PMID: 7127465]


Coronary sinus thrombosis., Parmar RC,Kulkarni S,Nayar S,Shivaraman A,, Journal of postgraduate medicine, 2002 Oct-Dec     [PubMed PMID: 12571393]


Sudden cardiac death due to primary coronary sinus thrombosis., Ramsaran EK,Sadigh M,Miller D,, Southern medical journal, 1996 May     [PubMed PMID: 8638186]


Unexpected sudden death from coronary sinus thrombosis. An unusual complication of central venous catheterization., Suárez-Peñaranda JM,Rico-Boquete R,Muñoz JI,Rodríguez-Núñez A,Martínez Soto MI,Rodríguez-Calvo M,Concheiro-Carro L,, Journal of forensic sciences, 2000 Jul     [PubMed PMID: 10914599]


Life-threatening coronary sinus thrombosis following catheter ablation: case report and review of literature., Yeo KK,Davenport J,Raff G,Laird JR,, Cardiovascular revascularization medicine : including molecular interventions, 2010 Oct-Dec     [PubMed PMID: 20934660]


Fatal cardiac tamponade due to coronary sinus thrombosis in acute lymphoblastic leukaemia: a case report., Kitazawa S,Kitazawa R,Kondo T,Mori K,Matsui T,Watanabe H,Watanabe M,, Cases journal, 2009 Nov 27     [PubMed PMID: 20062732]


Fatal coronary sinus thrombosis due to hypercoagulability in Crohn's disease., Martin J,Nair V,Edgecombe A,, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 2017 Jan - Feb     [PubMed PMID: 27776257]


Coronary sinus thrombosis: Echocardiographic visualization in a patient with known risk factors., Milligan G,Moscona JC,, Journal of clinical ultrasound : JCU, 2018 Feb 12     [PubMed PMID: 29430659]


Dramatic improvement of LV function after coronary sinus thromboembolectomy., Neri E,Tripodi A,Tucci E,Capannini G,Sassi C,, The Annals of thoracic surgery, 2000 Sep     [PubMed PMID: 11016343]


Pylephlebitis presenting as spontaneous coronary sinus thrombosis: a case report., Hart MA,Simegn MA,, Journal of medical case reports, 2017 Nov 2     [PubMed PMID: 29092714]


Basic determinants of epicardial transudation., Stewart RH,Rohn DA,Allen SJ,Laine GA,, The American journal of physiology, 1997 Sep     [PubMed PMID: 9321832]


Extreme clinical presentations of venous stasis: coronary sinus thrombosis., Kachalia A,Sideras P,Javaid M,Muralidharan S,Stevens-Cohen P,, The Journal of the Association of Physicians of India, 2013 Nov     [PubMed PMID: 24974504]


Transesophageal echocardiography diagnosis of coronary sinus thrombosis., Frogel JK,Weiss SJ,Kohl BA,, Anesthesia and analgesia, 2009 Feb     [PubMed PMID: 19151269]


Giant coronary sinus., Nathani S,Parakh N,Chaturvedi V,Tyagi S,, Texas Heart Institute journal, 2011     [PubMed PMID: 21720482]


Valente AM,Lock JE,Gauvreau K,Rodriguez-Huertas E,Joyce C,Armsby L,Bacha EA,Landzberg MJ, Predictors of long-term adverse outcomes in patients with congenital coronary artery fistulae. Circulation. Cardiovascular interventions. 2010 Apr;     [PubMed PMID: 20332380]