Saphenous Nerve Block

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Continuing Education Activity

The saphenous nerve block is widely used in both emergency and perioperative settings for procedural anesthesia and post-procedural pain management. This regional anesthesia procedure is often used to block pain in the medial leg and ankle and can be performed under ultrasound guidance. This activity describes the contraindications, complications, indications, and techniques involved in performing a saphenous nerve block and highlights the role of a well-informed interprofessional team in caring for patients undergoing this procedure.


  • Identify the anatomical structures involved in a saphenous nerve block.
  • Outline the indications for a saphenous nerve block.
  • Review the complications of a saphenous nerve block.
  • Explain interprofessional team strategies for enhancing care coordination and communication to advance the safe performance of the saphenous nerve block and improve patient outcomes.


The saphenous nerve block has wide use in both the emergency department and perioperative settings for procedural anesthesia and post-procedural pain management. This regional anesthesia procedure is often used to block pain from the medial leg and ankle and can be performed with ultrasound guidance.

Anatomy and Physiology

The saphenous nerve originates from the L3-L4 nerve roots and is a terminal branch of the femoral nerve. This purely sensory nerve innervates the medial, anteromedial, and posteromedial lower leg, ankle, and foot (Figure 1 and Figure 2).[1] It separates from the femoral nerve in the proximal third of the thigh, descends lateral to the femoral sheath in the adductor canal (a.k.a. subsartorial canal, Hunter canal), and crosses anteromedial to the femoral artery to emerge from the canal with the saphenous branch of the descending genicular artery.

After the saphenous nerve leaves the adductor canal, it pierces the fascia lata between the tendons of the gracilis and sartorius muscles to become subcutaneous. During this course, the nerve divides into the infrapatellar branch and the sartorial branch before dividing into multiple small subcutaneous branches. It travels laterally to the great saphenous vein as it descends the medial aspect of the lower leg, dividing into multiple small subcutaneous branches that provide sensory innervation to the medial aspect of the lower leg, ankle, and forefoot[2][3][4][5]


The saphenous nerve block is indicated whenever the need exists for anesthesia of the lower leg or foot along its neural distribution. It is most commonly used in conjunction with a popliteal sciatic nerve block to provide complete anesthesia of the lower leg for various surgical and nonsurgical procedures. These include saphenous vein stripping or harvesting, wound repair or exploration, ankle fracture or dislocation reduction, abscess drainage, and foreign body removal.


Absolute contraindications to the saphenous nerve block include allergy to anesthetic solution or additives, infection at the injection site, and patient refusal. Relative contraindications include coagulopathy, systemic infection, and pre-existing neurologic deficit in the distribution of the block.


The necessary equipment includes the following:

  • Antiseptic solution (povidone iodine or chlorhexidine gluconate)
  • Sterile gloves
  • Sterile drape
  • Face mask with eye shield
  • A linear ultrasound transducer (8-14 MHz) with sterile probe cover and gel
  • Local anesthetic, lidocaine 1%, for superficial numbing
  • Regional block local anesthetic, bupivacaine 0.5% or ropivacaine 0.5%
  • 10 mL syringe
  • 50-mm, 22-gauge short-bevel block needle


A medical professional with training in ultrasound guidance for regional anesthesia should perform the block.


The provider obtains informed consent in accordance with hospital policy. The patient should also undergo neurovascular and musculoskeletal examinations prior to the procedure.


The saphenous nerve block can be performed at the mid-thigh in the adductor canal or just below the knee depending upon the desired area of anesthesia. Although these locations are identifiable anatomically, ultrasound visualization has become the standard of practice.

The adductor canal approach to saphenous nerve blockade provides anesthesia at the level of the mid-thigh. Patient placement is in the supine position with the leg abducted and externally rotated to allow access to the medial thigh. The patient is prepared in a standard sterile fashion. A linear ultrasound transducer is placed perpendicular to the long axis of the lower limb, approximately 5 to 7 cm proximal to the popliteal crease, and slid proximally until the hyperechoic appearance of the vastoadductor membrane fades, and the femoral artery is identified. The saphenous nerve is identified as a hyperechoic circle anterolateral to the femoral artery. After negative aspiration, an in-plane approach is used to inject 5 to 10 mL of local anesthetic deep to the sartorius muscle and lateral to the artery.[3][6][7]

The saphenous nerve can be blocked below the knee for anesthesia of the lower leg and foot. The patient is positioned supine with the leg straight. After standard sterile preparation, a linear ultrasound transducer is placed at the level of the tibial tuberosity. A short-axis view of the saphenous vein and fascia lata is obtained, and local anesthetic is infiltrated between these two landmarks[8]

Saphenous nerve blockade may also be achieved more distally at the ankle, although the nerve is often not visible with ultrasound at this level. For this reason, a landmark based approach is more reliable but may require higher volumes of local anesthetic. After palpating the medial malleolus and great saphenous vein, local anesthetic is infiltrated approximately 2 cm anterior and posterior to the saphenous vein just superior to the medial malleolus. Ultrasound guidance is helpful if the saphenous vein cannot be visualized or palpated on exam. However, the saphenous nerve usually is not visible on ultrasound at this level[9]


Complications related to saphenous nerve block may include pain on injection, infection at injection site, bleeding, nerve injury, allergic reaction, and local anesthetic systemic toxicity. There is some controversy as to whether or not adductor canal blocks may result in quadriceps muscle weakness as a result of secondary blockade of the vastus medialis nerve.[10] However, several studies have reported that the adductor canal block results in little or no quadriceps muscle weakness, particularly when compared with the femoral nerve block.[7][11][12][13][14] Ultrasound visualization minimizes the likelihood of nerve injury, local toxicity, and vessel puncture.

Complications must be recognized and treated early to avoid long-term morbidity. Patients with suspected systemic toxicity should immediately receive intravenous lipid emulsion (Intralipid) therapy. The dose is 20% lipid emulsion as a 1.5 mL/kg bolus over 2 to 3 minutes, followed by a 0.25 mL/kg/min infusion. Consider consulting your poison control center for guidance.

Clinical Significance

The saphenous nerve provides pure sensory innervation to the anteromedial aspect of the lower leg. Blockade of the saphenous nerve, particularly when performed under ultrasound guidance, offers a safe and reliable option for anesthesia of the lower extremity and may help reduce utilization of systemic therapy, such as opioids.

Enhancing Healthcare Team Outcomes

Performance of the saphenous nerve block requires interprofessional collaboration between the proceduralist, nursing staff, and clinical pharmacist. The patient should be on continuous hemodynamic monitoring and emergency airway equipment, supplemental oxygen, and resuscitation drugs (including lipid emulsion) kept immediately available. All team members should know the early symptoms of local anesthetic systemic toxicity (i.e., tinnitus, circumoral numbness, and metallic taste) and awake patients advised to report them. Early recognition and treatment are vital to avoid more severe complications including seizures and cardiovascular collapse. Providers should calculate the maximum weight-based dose of local before the start of the procedure and should use the lowest effective dosing to minimize the risk of systemic toxicity; this should include the clinician pharmacist in a collaborative effort. Nursing will assist in the procedure and provide patient monitoring, informing the clinician of any concerns that may arise. With an interprofessional approach to a saphenous nerve block, outcomes will be optimized.

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Saphenous Nerve Block Image
Saphenous Nerve Block Image
Contributed by Mark Brady, MD
Article Details

Article Author

Cosby Arnold

Article Author

Andrea C. Alvarado

Article Editor:

Mark F. Brady


5/29/2022 11:56:45 PM



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