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Continuing Education Activity

Doxylamine is a medication used to manage and treat nausea and vomiting of pregnancy (NVP), allergic rhinitis, and insomnia. It is in the first-generation histamine receptor H1 antagonist class of medications. This activity reviews the indications, action, and contraindications for doxylamine as a valuable agent in managing nausea and vomiting of pregnancy (NVP), allergic rhinitis, and insomnia.


  • Identify the mechanism of action of doxylamine.
  • Describe the potential adverse effects of doxylamine.
  • Summarize the toxicity of doxylamine.
  • Review interprofessional team strategies for improving care coordination and communication to advance doxylamine and improve outcomes.


Doxylamine succinate with pyridoxine has approval from the U.S. Food and Drug Administration for the first-line treatment of nausea and vomiting of pregnancy (NVP).[1]  NVP affects up to 85% of women during pregnancy—it is the most prevalent medical condition during pregnancy.[2] Most patients with NVP are manageable by making alterations to diet and lifestyle factors; however, more than 30% might need fluids, vitamin supplementation, and additional treatment with an antiemetic such as doxylamine.[3]

Like other antihistamines, it also has utility for the management of allergic rhinitis.[4] Allergic rhinitis is the most prevalent atopic disorder, and symptoms consist of nasal congestion, sneezing, rhinorrhea, and nasal itching.[5] Doxylamine tablets are also available over-the-counter as an approved sleep aid for insomnia.[6] Insomnia is among the most commonly encountered patient concerns, and it can have significant adverse effects on mental and physical health.[7]

Mechanism of Action

As a member of the first-generation class of antihistamines, doxylamine exerts its effects by competitively antagonizing the binding of free histamine at the H1-receptor binding sites. It antagonizes the effects of histamine in the uterus, GI tract, large blood vessels, and bronchial muscles. Doxylamine binds non-selectively to H1-receptors, both centrally and peripherally, contributing to the sedative effects that also make it an effective sleeping aid. However, due to their interactions with receptor residues that remain highly conserved across the aminergic receptors, H1 receptor antagonists can produce several off-target effects; these are anticholinergic. This activity also depresses labyrinthine function, blocks the chemoreceptor trigger zone, and diminishes vestibular stimulation.[8] Furthermore, doxylamine reduces nausea and vomiting by inhibiting histaminergic signaling to the vomiting center in the medulla.[9] The mechanism of action of pyridoxine while treating NVP is unknown.


Doxylamine is often co-administered with pyridoxine (vitamin B6) as an extended-release oral tablet (doxylamine succinate 10 mg/ pyridoxine-HCl 10 mg). The tablets should not be crushed, chewed, or split to maintain the extended-release effects.[10] For NVP, the recommended dose is two tablets before bed with water on an empty stomach. If symptoms continue on the second day, the patient can take one tablet after waking in the morning and two at night. If symptoms are still inadequately controlled with a three tablet regimen on the third day, the dose could increase to four tablets per day: one in the morning, one mid-afternoon, and two before bed. The maximum daily limit is four tablets.

Patients should not take doxylamine/pyridoxine as needed while treating NVP. The need for continued therapy requires reassessment throughout the pregnancy.[11][12][13] Doxylamine as a standalone medication is also available as doxylamine succinate 25 mg oral tablets under both brand and generic forms. These serve as a sleep aid, so the medication should be administered 30 minutes before bedtime.[14]

Adverse Effects

Because doxylamine is available over the counter, the risk of overdose is a concern.[4] Adverse effects due to hypersensitivity to the drug include hypotension, urticaria, and decreased oxygen saturation.[15] Common adverse effects include impaired vigilance, atropine-like effects, and drowsiness during the day—all of which could pose problems for high-risk fall patients and those operating heavy machinery.[16] 

Doxylamine and other first-generation histamine H1 receptor antagonists can bind to and inhibit muscarinic receptor signaling in other organ systems, resulting in systemic anticholinergic effects. This non-selective receptor binding can lead to various adverse effects such as flushing of the skin, anhidrosis, hyperthermia, hallucinations, mydriasis, delirium, and urinary retention.[17] Doxylamine is safe for use in breastfeeding in small, occasional doses. In longer-term or higher doses, doxylamine might decrease lactation, and it could cause drowsiness or other adverse effects on the breastfed infant.[18] Doxylamine is safe for use in pregnancy, as it is not teratogenic.[3]


One contraindication to treatment with doxylamine includes concurrent use of a monoamine oxidase inhibitor (MAOI).[13] Hypersensitivity to doxylamine is a contraindication to its use.[15] Concomitant alcohol use is contraindicated due to its effect of causing pronounced somnolence when combined with doxylamine. Doxylamine contraindications also include patients with the following conditions: elevated intraocular pressure, narrow-angle glaucoma, asthma, stenosing peptic ulcer disease, urinary bladder neck obstruction, gastric outlet obstruction.[11]


Researchers have mostly studied the pharmacokinetics of doxylamine in healthy nonpregnant women. Doxylamine is absorbed in the gastrointestinal tract, mainly the jejunum. With extended-release formulation, peak plasma concentrations occur within 7.5 hours.[13] Doxylamine is highly lipophilic; therefore, it circulates as 98% protein-bound. The volume of distribution is between 0.5 and 30 L/kg. Doxylamine undergoes hepatic metabolism via a dealkylation reaction, so the clinician should consider the patient's liver function.[17] Additionally, doxylamine and its respective metabolites get excreted by the kidneys, so clinicians should consider the patient's renal function when administering this drug. The half-life of doxylamine is 11.9 hours, and the half-life of coadministered pyridoxine is 0.4 hours.[11]


Toxicity associated with antihistamine use is due to overdose following oral ingestion, either unintentional or intentional suicide attempt—most commonly in young and elderly populations. Toxicity from intravenous, intramuscular, or topical routes of administration rarely occurs in the household setting. Toxicity presents as antimuscarinic and hallucinogenic effects. The mnemonic 'dry as a bone, hot as a hare, red as a beet, blind as a bat, full as a flask, and mad as a hatter' has been used to remember the presentation of acute anticholinergic toxicity. This mnemonic represents the findings of anhidrosis, hyperthermia, reddening of the skin, mydriasis, hallucinations, urinary retention, and delirium, respectively.

Major complications of doxylamine toxicity include arrhythmias, respiratory failure, seizures, hyperthermia, rhabdomyolysis, and coma. If the patient experiences toxicity, the healthcare team should constantly monitor cardiac activity, and IV access is necessary. Patients who only recently ingested the toxic dose can receive activated charcoal.[17][19]

Enhancing Healthcare Team Outcomes

Doxylamine is available both over-the-counter and through a consultation with a physician. It is a first-generation histamine H1 receptor antagonist that can lead to various adverse outcomes if consumed inappropriately. Over-the-counter availability of doxylamine to consumers demands the need to educate patients and the general public on appropriate antihistamine consumption and how to recognize signs of toxicity. Individuals taking doxylamine should understand the potential adverse effects, and they should receive instruction to store this medication in a secure location where children or other individuals at risk of ingesting a toxic dose (intentionally or unintentionally) cannot access it. Patients should also be counseled on the potential drug interactions with doxylamine, such as increased somnolence and sedation when consumed with alcohol or other central nervous system depressants. 

An interprofessional healthcare team should be well-versed in recognizing the symptoms of doxylamine toxicity. They should be aware of the potential complications that can manifest, such as multiorgan failure and coma. Although most patients experience a full recovery following doxylamine toxicity, it is still vital that healthcare teams are knowledgeable and up to date on the presentation of doxylamine toxicity.[17] The prescribing clinician, along with a pharmacist, should educate about dosing and interactions. The pharmacist (as well as nursing) can counsel the patient on administration and potential adverse effects. Nursing can also perform follow-up monitoring and also act as a bridge between the prescriber and the patient. These examples of interprofessional collaboration show how to optimize doxylamine therapy for the best clinical results. [Level 5]

Historically, there has been significant debate around a reported correlation between using a combination product containing doxylamine and pyridoxine in the 1970s and congenital disabilities. Media and law firms launched publicity campaigns against the older formulation, which eventually resulted in the discontinuation of the drug for decades until the newer formulation received approval in 2013 for treating NVP refractory to other nonpharmacological management. Approval of the newer formulation was based on randomized, placebo-controlled clinical trials supporting its efficacy and safety. It also considered extensive data concluding that combined treatment with doxylamine succinate and pyridoxine hydrochloride in pregnancy is not teratogenic. This decades-long debate and evidence reinforce the importance of evidence-based medicine. 

Article Details

Article Author

Nathan Brott

Article Editor:

Anil Kumar Reddy Reddivari


6/11/2021 10:06:33 AM

PubMed Link:




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