Patient-Controlled Analgesia (PCA) has been utilized to optimize pain relief since 1971, with the first commercially available PCA pump appearing in 1976. The goal of PCA is to efficiently deliver pain relief at a patient's preferred dose and schedule by allowing them to administer a predetermined bolus dose of medication on-demand at the press of a button. Each bolus can be administered alone or coupled with a background infusion of medication. PCA is used to treat acute, chronic, postoperative, and labor pain. These medications can be administered intravenously, epidurally, through a peripheral nerve catheter, or transdermally. Drugs commonly administered are opioids and local anesthetics, but dissociatives or other analgesics are also options. PCA has proven to be more effective at pain control than non-patient opioid injections and results in higher patient satisfaction.
Anatomy and Physiology
Modalities for PCA administration include intravenous lines, central lines, epidural catheters, peripheral nerve catheters, or transdermal delivery systems. Any peripheral vein can be used to insert a catheter and begin the administration of PCA. Central lines placed in the internal jugular, subclavian, or femoral veins. Epidural catheters placement is in the epidural space between the dura and the ligamentum flavum, which lines the anterior portions of the vertebral lamina. Within the epidural space sits spinal nerves, blood vessels, and fat. Indwelling epidural catheter placement is at thoracic and lumbar spinal levels. Peripheral nerve catheters are placed adjacently to the nerve or plexus; they are intended to block continuously. These will run through the skin and potentially muscle depending on the desired target location. Transdermal PCA delivery is through a fentanyl iontophoretic transdermal system, which is placed on the epidermis and will provide a dose of fentanyl when the patient pushes a button on the patch.
PCA can be an option for acute, chronic, postoperative, and labor pain, especially in patients who are unable to tolerate oral medications. PCA can be used to reduce the stress on the nursing staff and the patient of having to adhere to a predetermined dosing schedule of as-needed analgesics that may not adequately align with the patient’s fluctuation of pain. PCA can be useful in the acute pain setting where there is inadequate pain control from the initial opioid administration in the emergency department, and continued opioid dosing has been proven to improve patient outcomes. Common examples are vaso-occlusive pain crisis, trauma, pancreatitis, or burns. PCA would be used as an adjunct therapy to treat the pain while the underlying cause gets diagnosed and treated. Patients with chronic illnesses who are suffering from lower levels of constant chronic pain would also be candidates for PCA. The most common examples are metastatic cancer, phantom limb syndrome, and complex regional pain syndrome. Post-surgical patients, especially those with indwelling nerve or epidural catheters, are also ideal candidates for PCA. The ability of a post-surgical patient to titrate and administer their own pain medication allows for superior pain control to scheduled nursing dosing. It also increases patient satisfaction and will result in less intervention by PACU and acute pain service staff. Patients in labor pain are also well-established candidates for epidural PCA. The pain associated with contractions, especially when exacerbated by induction agents such as oxytocin, can be adequately reduced and controlled by the patient.
Absolute contraindications to PCA include:
- The patient is unable to understand the concept behind PCA
- Systemic infection, or infections at the preferred site of PCA placement
- Allergic reactions to the selected medication
- Burns or trauma on the area of PCA placement
- Preexisting neural deficits in the area of a planned indwelling nerve catheter
- Increased ICP for epidural catheter placement
Relative contraindications to PCA include:
- Chronic renal failure
- The patient is on antithrombotic therapy
- The patient has a documented bleeding disorder
- Sleep apnea
The administration of PCA requires the selection of route, medication, and type of pump to in use.
The route for PCA administration can be through an intravenous catheter, epidural catheter, indwelling nerve catheter, or an iontophoretic transdermal system. The equipment and procedure for the placement of these devices appear in the articles for those specific modalities.
There are a variety of PCA pumps on the market, and all contain the essential components of a locking device, medication chamber, programming screen, and patient button. A provider will insert a syringe of medication into the pump and program the pump to the prescribed initial loading dose, PCA dose, lockout interval, continuous infusion rate, and one and four-hour limits. For intravenous PCA, the medication line then gets connected to a fluid infusion line. It is best to familiarize yourself with your specific institution's pump and protocols for PCA administration.
Medications commonly used are opioids and local anesthetics. Opioids are either used alone for intravenous PCA or in conjunction with local anesthetics for epidural catheter PCA.
Opioid medications include pure Mu opioid receptor agonists (morphine, fentanyl, hydromorphone, meperidine, sufentanil, alfentanil, and remifentanil) Mu opioid receptor agonist-antagonists (butorphanol, nalbuphine, pentazocine) and partial Mu opioid receptor agonists (buprenorphine, dezocine). Despite a variety of medication options, morphine remains the gold standard medication for intravenous PCA.
Local anesthetics are primarily used for epidural catheter and indwelling nerve catheter PCA. They include the sodium channel blockers (bupivacaine, levobupivacaine, and ropivacaine).
Other medications can be added to intravenous PCA in an attempt to reduce side effects and improve pain control. They include ketamine, naloxone, clonidine, magnesium, ketorolac, lidocaine, and droperidol. Experiments with these additional medications have had a variety of efficacy, but the mainstay of PCA remains opioids and local anesthetics.
Multiple staff members are necessary to effectively and safely administer PCA. Individual roles include the physician ordering the route, medication, and dosing, the pharmacist preparing the drug, and the nurse setting up the pump and explaining its use to the patient while periodically monitoring them throughout their use of the device. Lastly, the patient will be personally pressing the administration button.
Before the administration of intravenous PCA, the patient needs pre-procedure assessments across a variety of domains, including cognitive, opioid naivety, pain, sedation, and respiratory assessments. A pre-procedure cognitive assessment ensures the patient has the mental capacity to participate in PCA and can understand the concepts of dosing, interval, lockout, and expected pain relief. Whether the patient is opioid naïve will determine the initial dosing, titration, and expected pain relief and side effects. Periodic pain assessments using the numerical pain rating scale are necessary to create a baseline before PCA begins and to track its efficacy throughout treatment. A sedation assessment should also take place before the procedure begins and periodically throughout. Finally, a respiration assessment of the rate, depth, effort, and sound of breaths should be performed to establish a patient baseline and to monitor the effects of the medications during treatment. These assessments allow for adjustments to be made during administration to meet desired outcomes.
Before the administration of PCA through a peripheral nerve catheter or an epidural catheter, a neurological exam assessing for pain sensation, light touch sensation, and motor function over the targeted dermatomes and myotomes require assessment, allowing for the establishment of a baseline function and sensation to be tracked throughout PCA administration.
PCA dosing contains a variety of variables, including the initial loading dose, bolus or demand dose, lockout interval, continuous infusion rate, and one and four-hour limits. The initial loading dose can be titrated by a nurse to reach the minimum effective concentration (MEC) of the desired medication. The bolus or demand dose is the dose of medication delivered each time the patient presses the button. A lockout interval is the time after a demand dose in which a dose of medication will not get administered even if the patient presses the button; this is done to prevent overdosing. A continuous infusion rate can be used in the background of PCA dosing to maintain the MEC of the medication independent of patient demands. One and four-hour limits put a cap on the maximum allowed amount of medication to be administered within those time periods and are usually less than the dose given if the patient were to press the dosing button at every possible interval. This mechanism allows for an added safety benefit and can notify the nurse and provider that the patient’s pain is not under adequate control with the prescribed medication and dosing parameters.
There is a variety of debate and discussion about different dosing strategies regarding PCA such as how much of a loading dose to administer, which medications to use, the amount of drug in the demand dose, the duration of lockout interval, whether to add a continuous background infusion, and what one and four-hour maximums should be. It is best to review the specific literature on PCA dosing strategies for the pain condition you are attempting to treat with PCA.
The use of PCA has been proven to be more effective at pain control than non-patient controlled opioid injections and results in higher patient satisfaction. PCA has also been found to be preferred by nurses because it allows for a reduction in their workload. PCA will enable patients to be in more control over their pain and helps them shift toward a more internal locus of control over their care.
PCA has been found to be less cost-effective than traditional dosing and does not affect the average length of hospital stay. When comparing PCA to traditional dosing, it was documented to result in higher opioid consumption, but those same studies also found no significant difference between opioid-related side effects, potentially indicating that the amount of opioid consumption is irrelevant.
Enhancing Healthcare Team Outcomes
PCA can be an effective way to control acute, chronic, postoperative, and labor pain. However, it requires a competent interprofessional healthcare team consisting of a physician, pharmacist, nurse, and patient. It is essential to educate healthcare team members about the variety of routes, medications, dosing regimens, complications, pre-procedure, and post-procedure assessments, side effects, and expected outcomes involved. The pharmacist should double-check the dose and ensure that the delivery rate is safe. The nurses should double-check the order and ensure that the correct amount of drug is delivered. The team can inspect the records kept by the device and see if dosing has been optimal for patient pain control. While PCA can reduce the direct involvement of a physician and nurse in pain control, a supervisory role is still necessary to monitor the proper function and effectiveness of the PCA treatment along with the avoidance of undesired outcomes. The entire interprofessional team must communicate with each other to achieve optimal pain control results and avoid poor outcomes. [Level 5]
Nursing, Allied Health, and Interprofessional Team Interventions
The nurses should monitor the patient carefully and frequently to assess pain and sedation levels every one to two hours for the first 24-48 hours because the patient is at the highest risk of hypoventilation and nocturnal hypoxemia during this time. Other routine opioid medications ordered for the patient should be avoided when the patient is using an opioid PCA. Nurses should assess for comfort using standard numeric or behavior scales and evaluate the number of demands the patient has made for medication. Based on the patient's requirements, the dose of the PCA can be adjusted.
Nursing, Allied Health, and Interprofessional Team Monitoring
Nurses are responsible for the placement of peripheral intravenous lines, setup of PCA pumps, insertion of medication into the pumps, and monitoring of the patient’s pain, sedation, and respiration. They ensure that the pump is functioning correctly, and the medications are achieving their intended purpose while avoiding complications and reducing side effects.
While PCA can reduce the need to round and respond to patient calls to administer analgesics, it does not diminish their workload; this is because of the time and effort needed to educate the patient, set up the machine, and monitor its effectiveness and side effects. However, it has been shown to be a preferred method because nurses and patients have more control over their work and pain, respectively.