Knee Arthroplasty

Continuing Education Activity

Knee arthroplasty is the reconstruction of the knee joint. It is more commonly referred to as a total knee replacement and is a very reliable procedure with predictable results. Total knee arthroplasty (TKA) is an excellent treatment option for individuals with symptomatic osteoarthritis in at least 2 of the 3 compartments of the knee who have failed conservative treatment. This activity describes the indications, contraindications and complications of total knee arthroplasty and highlights the role of the interprofessional team in the management of patients with knee arthritis.


  • Describe the indications for total knee arthroplasty.
  • Outline the contraindications to total knee arthroplasty.
  • Summarize the complications of total knee arthroplasty.
  • Explain the importance of enhancing care coordination among interprofessional team members to improve outcomes for patients undergoing total knee arthroplasty.


Knee arthroplasty is a reconstruction of the knee joint. It is more commonly referred to as a total knee replacement and is a very reliable procedure with predictable results. Total knee arthroplasty (TKA) is an excellent treatment option for individuals with symptomatic osteoarthritis in at least 2 of the 3 compartments of the knee and who have failed conservative treatment.[1][2] Additionally, partial knee arthroplasty (PKA) is an excellent treatment option for individuals with symptomatic osteoarthritis localized to 1 compartment of the knee and who have failed conservative treatment.[3] The primary goal of either surgery is durable pain relief with the improvement of functional status. 

The history of TKA dates back to the mid to late 1800s when the first implants were made from ivory and fixed to the bone using a combination of colophony and plaster of Paris. This design did not produce favorable results and was eventually replaced with metal implants in the 1930s. In the 1950s, a hinged prosthesis was designed to replace the femur and tibia, as well as the stabilizing ligaments surrounding the knee. While this produced satisfactory results, there was a high rate of failure and poor long-term outcome due to the failure of reproducing the natural kinematics of the knee joint.  This was subsequently replaced with a prosthesis that replicated the shape of the distal femur, preserved the collateral and cruciate ligaments, and consisted of a plastic bearing on the tibia. Since this breakthrough in prosthesis in the 1970s, the design has evolved to focus on replicating the anatomy and normal function of the knee joint. Furthermore, advances have been made in fixation techniques and wear properties of the bearing surface which positively affects the longevity of the knee replacement.[4]

Anatomy and Physiology

The knee is a synovial hinge joint with minimal rotational motion. It is comprised of the distal femur, proximal tibia, and the patella. There are 3 separate articulations and compartments: medial femorotibial, lateral femorotibial, and patellofemoral. The stability of the knee joint is provided by the congruity of the joint as well as by the collateral ligaments. The capsule surrounds the entire joint and extends proximally into the suprapatellar pouch. Articular cartilage covers the femoral condyles, tibial plateaus, trochlear groove, and patellar facets. Menisci are interposed in the medial and lateral compartments between the femur and tibia which act to protect the articular cartilage and support the knee.

The mechanical axis of the femur, defined by a line drawn from the center of the femoral head to the center of the knee, is 3 degrees valgus to the vertical axis. The anatomic axis of the femur, defined by a line bisecting the femoral shaft, is 6 degrees valgus to the mechanical axis of the femur and 9 degrees valgus to the vertical axis.[5] The proximal tibia is oriented to 3 degrees of varus. The varus position of the proximal tibia, along with the offset of the hip center of rotation, results in the weight-bearing surface of the tibia being parallel to the ground. The sagittal alignment of the proximal tibia is sloped posteriorly approximately 5 to 7 degrees. The asymmetry of the natural bony anatomy maintains the alignment of the joint and ligamentous tension.


TKA is a well-described treatment option for patients suffering from knee pain secondary to osteoarthritis who have failed conservative treatment measures. It is a reliable procedure that provides pain relief and improves the patient’s functional status.[2] Furthermore, the need for correction of a significant or progressive deformity at the knee with evidence of osteoarthritis can also be an indication for a TKA. A patient with persistent knee pain without radiographic evidence of knee osteoarthritis should have further workup to exclude other possible sources of their pain.

Clinical symptoms of osteoarthritis include:

  • Knee pain
  • Pain with activity and improving with rest
  • Pain gradually worsens over time
  • Decreased ambulatory capacity

Clinical evaluation includes:

  • Full knee exam including range of motion and ligamentous testing
  • Knee radiographs include standing anteroposterior, lateral, 45-degree posteroanterior, and skyline view of the patella

Radiographic evidence of osteoarthritis include[6]:

  • Joint space narrowing
  • Subchondral sclerosis
  • Subchondral cysts
  • Osteophyte formation

Conservative treatment includes:

  • Non-steroidal anti-inflammatory medication
  • Weight loss
  • Activity modification
  • Bracing
  • Physical therapy
  • Viscosupplementation
  • Intra-articular steroid injection



  • Active or latent (less than 1 year) knee sepsis
  • Presence of active infection elsewhere in body
  • Extensor mechanism dysfunction
  • Medically unstable patient


  • Neuropathic joint
  • Poor overlying skin condition
  • Morbid obesity
  • Noncompliance due to major psychiatric disorder, alcohol, or drug abuse
  • Insufficient bone stock for reconstruction
  • Poor patient motivation or unrealistic expectation
  • Severe peripheral vascular disease


A TKA system will consist of instrumentation that helps the surgeon prepare the ends of the femur, tibia, and patella to receive an implant.  The instrumentation will be specific to the brand and type of implant being used with each company and model having specific intricacies.

In general, the instrumentation will consist of:

  • Intramedullary femoral guide to help establish the distal femoral alignment
  • Distal femoral cutting guide
  • Femoral sizing guide
  • 4-in-1 femoral cutting guide
  • Extramedullary or intramedullary tibial guide
  • Proximal tibial cutting guide
  • Patella sizing guide
  • Femoral component trial
  • Tibial baseplate trial
  • Patellar button trial
  • Trial plastic bearing

The final implants will come in individual sterile packages and will consist of:

  • Femoral component, typically made of cobalt-chrome
  • Tibial component, typically made of cobalt-chrome or titanium
  • Tibial polyethylene bearing, made of an ultra high molecular weight (UHMW) polyethylene
  • Patellar button, made of UHMW polyethylene


  • Anesthesia team
  • Operating room nurse
  • Surgical technician
  • Surgical assistant


  • Full medical and drug history before surgery
  • Appropriate pre-surgical workup, clearance, and optimization
  • Pre-operative radiographs of the affected knee
  • Pre-operative templating of the affected knee to estimate the component size
  • Primary TKA system of choice
  • Have various final implant sizes ready and available in the hospital
  • Have increasing prosthesis constraint options ready and available in the hospital
  • Have revision total knee replacement system of choice ready and available if needed
  • +/- antibiotic cement, surgeon preference


The goal of TKA is the same regardless of surgeon, implant, or technique. The variability in the procedure lies in the technique.  Some of the variations in operative technique for TKA are listed below.

  • General anesthesia versus regional anesthesia
  • Tourniquet versus tourniquet-less surgery
  • Standard versus patient-specific instrumentation
  • Standard versus patient-specific implants
  • Traditional versus robotic-assisted TKA
  • Traditional versus navigation-assisted TKA
  • Traditional versus sensor-assisted TKA
  • Measured resection versus gap balancing
  • Cruciate-retaining implant versus cruciate stabilized the implant
  • Resurfaced versus non-resurfaced patella
  • Cement versus cement-less (press fit) TKA


Potential complications include:[7][8]

  • Infection, superficial and deep
  • Blood clot
  • Pulmonary embolism
  • Fracture
  • Dislocation
  • Instability
  • Osteolysis resulting in component loosening
  • Pain
  • Stiffness             
  • Vascular injury
  • Nerve injury

Clinical Significance

The number of patients suffering from knee pain secondary to osteoarthritis will continue to rise, especially as the average life expectancy and obesity rates increase. These 2 factors contribute to the wear and tear of articular cartilage in the major weight-bearing joints seen in primary osteoarthritis.[9] Patients can also suffer from secondary osteoarthritis, or osteoarthritis caused by an abnormal concentration of force across the joint such as in rheumatoid or post-traumatic cases. In either case, a thorough history and physical and appropriate radiographs are essential to the appropriate diagnosis. Initial treatment is conservative and includes any and all combinations listed above. Once conservative treatment is no longer effective, surgical intervention may be considered. TKA is a reliable surgical procedure with a predictable outcome in the appropriate patient. Reported survival rates are upward of 85% with 10 to 25 years of follow-up.[10][11][10] Improvements in pain scores and functional scores are commonly recognized with the procedure as well.

Enhancing Healthcare Team Outcomes

While knee arthroplasty is done by the orthopedic surgeon, to ensure good outcomes an interprofessional team is required that includes a physical therapist, nurses, an internist, and the primary care provider. After surgery, the patients require physical therapy to regain muscle mass and joint function. In addition, for good outcomes, the patients need to exercise and maintain a healthy weight. Nurses should educate the patient on a healthy diet, avoidance of tobacco and taking part in regular exercise.

(Click Image to Enlarge)
Anteroposterior view of a periprosthetic distal femur fracture about a cemented cruciate retaining total knee arthroplasty
Anteroposterior view of a periprosthetic distal femur fracture about a cemented cruciate retaining total knee arthroplasty
Contributed by Daniel Mesko, DO

(Click Image to Enlarge)
Lateral view of a periprosthetic distal femur fracture about a cemented cruciate retaining total knee arthroplasty
Lateral view of a periprosthetic distal femur fracture about a cemented cruciate retaining total knee arthroplasty
Contributed by Daniel Mesko, DO
Article Details

Article Author

Hunter Hsu

Article Editor:

Ryan Siwiec


7/31/2020 3:20:52 PM

PubMed Link:

Knee Arthroplasty



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