Continuing Education Activity

Many healthcare practitioners insert central lines. Central line placement is essential in caring for many critically ill and hospitalized patients. Like any procedure, it has its complications, some of which can be life-threatening. Complications of central line placement include pneumothorax, hematoma, bleeding, infection, and extravasation. Understanding this procedure's proper technique and potential complications can help minimize central line-associated complications and improve clinical outcomes. This activity reviews the indications, techniques, possible complications, and ways to reduce the risk of complications associated with central line placement to increase healthcare provider knowledge and ability of the procedure and improve clinical outcomes.

Objectives:

• Describe the anatomy that is relevant to central line placement.
• Outline the complications associated with central line placement.
• Summarize the equipment required for central line placement.
• Explain a structured, interprofessional team approach to provide effective care and appropriate surveillance of patients undergoing central line placement.

Introduction

A central venous line (CVL) is a large-bore central venous catheter placed using a sterile technique (unless an urgent clinical scenario prevents sterile technique placement) in specific clinical procedures.[1] Sven-Ivar Seldinger, in 1953 introduced the method to facilitate catheter placement into the central veins lumens.[2] Now referred to as the Seldinger technique, this procedure allows the safe and reliable insertion of a central venous catheter in the large lumen central veins. Central line placement is an essential skill, especially in critical care units. According to epidemiologic data, 8% of hospitalized patients require central venous access, and more than 5 million central venous catheters are inserted in the United States annually.[3][4] 

Over the past decade, there has been tremendous improvement and reduced complications associated with central line placement procedures. With ultrasound guidance, standardized techniques, new catheter designs, and central line care bundle, this procedure has become ubiquitous in the intensive care unit. This article will detail the anatomy of the site placement, indications and contraindications, equipment and personnel involved, technique, preparation, and associated complications. 

Anatomy and Physiology

There are three possible sites for CVL placement in adult patients: namely, the internal jugular, femoral, and subclavian. The right internal jugular and subclavian valves are the most direct paths to the right atrium via the superior vena cava. The femoral veins are compressible sites and, as such, may be more appropriate for patients who are at high risk of bleeding. The subclavian vein approach is at higher risk for pneumothorax than the internal jugular vein approach. Ultrasound guidance can benefit all approaches and is recommended for every CVL placement. However, when ultrasound guidance is not feasible, CVLs may be placed using anatomical landmarks without ultrasound.

Internal Jugular Vein Access

The internal jugular vein exits the skull base from the jugular foramen collecting blood from the sigmoid sinus. It is contained within the carotid sheath and travels with the carotid artery and the vagus nerve. As it travels towards the chest, it assumes an anterolateral position to the common carotid artery beneath the sternocleidomastoid muscle.[5] Caudal to the cricoid cartilage, the internal jugular vein can be found between the two heads of the sternocleidomastoid muscle at the base of the neck.[6] Here the vein is most superficial, located only 1 to 1.5 cm below the skin surface in most patients.[6] As it courses forward, it joins the subclavian vein to form the brachiocephalic (innominate) vein.[6]

Right internal jugular venous access allows a straight and direct path to the superior vena cava and has a low rate of catheter malposition during placement.[7] It is often the preferred site of access for CVL placement. Contraindications to internal jugular venous access include severe coagulopathy, the presence of another device at the site, and altered local anatomy, especially if there is a concern for thrombosis from initial catheter placement.[7]

Subclavian Vein Access

Lateral to the suprasternal notch, the clavicle has an anterior convexity in the medial two-thirds of the bone and an anterior concavity in the lateral third. The center of this anterior convexity is known as the "bend" of the clavicle and is an essential landmark in the infraclavicular approach to subclavian vein access. The subclavian vein can be found by inserting the needle 2 to 3 cm inferior to the midpoint of the clavicle, which is 1 to 2 cm lateral to the "bend" of the clavicle.[8] The subclavian vein forms from the axillary vein, arching cephalad behind the medial clavicle, and slopes caudally. Here it joins the internal jugular vein to form the brachiocephalic (innominate) vein, just posterior to the sternoclavicular joint. The subclavian artery is superior and posterior to the subclavian vein, separated by the anterior scalene muscle. The lung is deep and inferior to the access point of the subclavian vein using the infraclavicular approach. The phrenic nerve is located inferiorly, and the brachial plexus is superior. The left-sided thoracic and right-sided lymphatic ducts can be found posterior to the subclavian vein.

The subclavian vein access site is incompressible and, as such, should be avoided in patients with severe coagulopathy and an increased risk of bleeding.[9] However, a retrospective analysis of patients with bleeding disorders who required central line placement revealed that CVLs could be safely performed in these patients when performed by expert hands.[9]

Femoral Vein Access

The common femoral vein is located superficially at the femoral triangle, just distal to the inguinal ligament. It is located within the femoral sheath and lies medial to the femoral artery within the femoral triangle. The femoral artery pulsation is used as an anatomic landmark to find the common femoral vein. The mid-inguinal point between the anterior superior iliac spine and the pubic tubercle is lateral to this pulsation. This landmark can be used when the femoral artery is not palpable. 

The femoral vein access site is more prone to catheter-related deep vein thrombosis when compared with jugular or subclavian access sites.[10] This access site was considered at higher risk of catheter-related infections; however, recent studies have shown that catheter-related infections are similar at all three sites when optimal insertion points are selected, and the procedure is performed using strict sterile techniques by expert hands.[11][12] Still, current Centers for Disease Control and Prevention (CDC) guidelines recommend avoiding femoral site access unless the internal jugular and subclavian sites are unavailable.

Indications

Indications for placing a CVL include the following:

• Drug infusions that could otherwise cause phlebitis or sclerosis (e.g., vasopressors and hyperosmolar solutions)
• Monitoring
  • Central venous pressure
  • Central venous oxyhemoglobin saturation (ScvO2)
  • Pulmonary artery pressure
• Emergency venous access (due to difficult peripheral intravenous access)
• Transvenous pacing wire placement
• High-volume/flow procedures requiring large-bore access (hemodialysis and plasmapheresis)
• Vena cava filter placement
• Venous thrombolytic therapy[13][14]

Contraindications

Contraindications for central venous access are always relative and dependent on the urgency and alternative venous access. Site-specific contraindications include distorted local anatomy, skin infection overlying the insertion site, thrombus within the intended vein, or the presence of other indwelling intravascular hardware within the intended vessel. Coagulopathy and bleeding disorders are considered relative contraindications even when they are severe. A systematic review studying the risk of complications following CVL placement in patients with moderate-to-severe coagulopathy and thrombocytopenia revealed that the incidence of major bleeding complications is low, and evidence supporting the correction of coagulopathy before CVL placement is lacking. [15] Ultrasound-guided placement of CVL is the method of choice in patients at high risk of bleeding due to underlying disorders of hemostasis, as it allows for safe and reliable access to central veins with low rates of complications and lesser attempts in patients with these disorders.[16]

It still needs to be determined what thresholds of platelet count, international normalized ratio (INR), and partial thromboplastin time central venous catheterization can safely be performed. According to recent data, thrombocytopenia appears to pose a greater risk when compared with prolonged clotting times.[17][18] Despite common concerns and practice, there is limited evidence supporting routine correction of coagulopathy before central venous cannulation.[10][15][19][20] Retrospective studies suggest that no pre-procedure reversal warrants platelet count > 20 x 10/L and INR < 3.[10] For severe coagulopathy (e.g., platelet count <20 x 10/L and INR >3), administration of a pre-procedure blood product (e.g., platelets, fresh frozen plasma) should be considered when time allows. Based on the clinical decision, it should be that the benefit of pre-procedure replacement outweighs the risk. 

Equipment

Most central line kits include:

• Syringe and needle for local anesthetic
• A small vial of 1% lidocaine
• Syringe and introducer needle
• Scalpel
• Guidewire
• Tissue dilator
• Sterile dressing
• Suture and needle
• Central line catheter (of which there are several types and sizes, including triple-lumen, double-lumen, and large bore single-lumen)

In addition, the operator will require a sterile gown, cap, gloves, sterile gauze, sterile saline, face mask, and a sterile cleansing solution such as chlorhexidine. The operator should also ensure that ultrasound, sterile ultrasound gel, and a sterile ultrasound probe are part of the setup.[13] A 16- cm CVL should prevent intracardiac placement and arrhythmias when attempting to cannulate the subclavian or internal jugular veins.[7]

Personnel

The personnel required for passing central venous catheter is the proceduralist, technician, and nurse. 

Preparation

Nontunneled central venous catheters are usually placed at the bedside. Informed consent needs to be obtained before the procedure in most cases. In an emergency, however, consent is implied. The proceduralist should convey the procedure indication, plan, benefits, and potential complications (e.g., pneumothorax) to the patient and legal guardian. The need to perform another procedure, such as placing a chest tube for pneumothorax, should also be conveyed while taking consent for the procedure. An appropriate position of the patient for the selected site is necessary. In the case of the internal jugular and subclavian access, a 15-degree Trendelenburg position should be obtained if feasible according to the clinical situation. This position also minimizes the risk of venous air embolism during the procedure.[17] In the femoral approach, the patient should be lying supine. Continuous cardiac rhythm monitoring and pulse oximetry of the patient's telemetry are necessary during the procedure.

Precannulation vein assessment via bedside ultrasonography is recommended to help identify relevant anatomy before the procedure and to help select the most appropriate site for the patient.[18]

A strict aseptic technique for site preparation and the operator is required. Surgical antiseptic hand wash, long-sleeved sterile gown, surgical mask, gloves, and head covering are required for the operator.[13] An antiseptic skin preparation solution should be used to clean the access site. Chlorhexidine-alcohol-based solutions with more than 0.5% chlorhexidine are preferred over povidone-iodine solutions due to their superior performance.[19] Systemic antimicrobial prophylaxis before this procedure is not recommended as it does not decrease the rate of catheter-related bloodstream infections.[20]

The patient should be covered in a sterile drape large enough to cover the entire patient, exposing only the cleaned access site. The ultrasound probe and gel should be placed in a sterile sheath with the help of a bedside assistant in a sterile fashion. By the end of the procedure, a timeout should be called with the assistant to confirm the patient, procedure, and site of the procedure.

SICSAG and HPS first published the central venous catheter placement insertion bundle and associated tools in May 2007. This bundle has five key aspects that minimize the risk of catheter-related bloodstream infection if addressed.[21]

Technique

• Infiltrate the skin with 1% lidocaine for local anesthesia around the needle insertion site.
• Using a sterile ultrasound conduction medium, use the bedside ultrasound to identify the target vein. The vein will appear round with a black center that is easily collapsable under pressure applied to the probe. The adjacent artery (carotid or femoral) will have apparent pulsations and minimal collapsibility. 
• If using landmarks, then follow the site-specific guidelines described below:
  • For internal jugular vein CVL (central approach), the needle should be inserted at the triangle's apex formed by the sternocleidomastoid muscle's two heads above the medial clavicle and is usually 5 cm superior to the clavicle. The needle should be inserted at 30 to 45 degrees into the skin. This should be lateral to the carotid pulsation, and the needle should be directed laterally in the sagittal plane towards the ipsilateral nipple.[22] Turning the patient's head to the contralateral side accentuates landmarks and facilitates CVL placement. 
  • For the subclavian vein CVL (infraclavicular approach), the needle should be inserted approximately 2 to 3 cm inferior to the midpoint of the clavicle, which is 1 to 2 cm lateral to the "bend." The needle should be directed posterior to the suprasternal notch.[8] An insertion that is lateral to the midclavicular line is preferred.[8] The needle should be advanced under the clavicle and kept parallel to the clavicle in the coronal plane. The vein will be accessed as the needle passes beneath the junction of the middle and medial thirds of the clavicle.
  • For femoral line CVL, the needle insertion site should be located approximately 1 to 3 cm below the inguinal ligament and 0.5 to 1 cm medial where the femoral artery pulsates.  
• Insert the introducer needle with negative pressure until venous blood is aspirated. For the subclavian CVL, insert the needle at an angle as close to parallel to the skin as possible until making contact with the clavicle, then advance the needle under and along the inferior aspect of the clavicle. Next, direct the tip of the needle towards the suprasternal notch until venous blood is aspirated. Whenever possible, the introducer needle should be advanced under ultrasound guidance to ensure the tip does not enter the incorrect vessel or puncture through the distal edge of the vein.
• Once venous blood is aspirated, stop advancing the needle. Carefully remove the syringe and thread the guidewire through the introducer needle hub. The guidewire should only be inserted beyond the anticipated catheter length, avoiding intracardiac advancement. The telemetry monitor should be carefully watched to identify any arrhythmias induced by the guidewire. If an arrhythmia does occur, the guidewire should be pulled back until it resolves.[2] 
  • The average distance from a right internal jugular access site to the cavoatrial junction is 16 cm.[23] The average distance to the cavoatrial junction from the right subclavian access site, the left subclavian access site, and the left internal jugular access site are 18.4 cm, 21.2 cm, and 19.1 cm, respectively.[23] In most cases, 18 cm should be considered the upper limit of normal for guidewire length insertion regardless of the access site in subclavian and internal jugular cannulation. The guidewire should be advanced 25 cm for femoral access sites to ensure catheter placement within the inferior vena cava. 
  • Care is necessary to properly orient the J-tip guidewire when placing a subclavian venous catheter. In an infraclavicular approach, the bevel of the needle should be directed caudally to ensure adequate placement in the superior vena cava as opposed to internal jugular placement.[3]
• While holding the guidewire in place, remove the introducer needle hub.
• If possible, use the ultrasound to confirm the guidewire is in the target vessel in two different views.
• Next, use the scalpel tip to stab the skin against the wire, just large enough to accommodate the dilator. Insert the dilator with a twisting motion. The dilator need only be advanced to the anticipated depth of the targeted vein without dilating the vein itself. In an internal jugular venous access, this is usually 3 to 4 cm, and for subclavian access, this is usually 3 to 5 cm.[24]
• Advance the CVL over the guidewire. Ensure the distal lumen of the central line is uncapped to facilitate the passage of the guidewire. As discussed above, insertion length should be considered when placing the catheter. For most adults, 16 to 18 cm for right-sided and 20 cm for left-sided jugular catheters is sufficient.[25] Right-side subclavian venous catheters are generally placed at 16 cm, and left-sided catheters are placed at a depth of 20 cm.[25] Femoral venous catheters are placed at a length of 15 to 30 cm.
• Once the CVL is in place, remove the guidewire. Next, flush and aspirate all ports with sterile saline.
• Secure the CVL with sutures and place a sterile dressing over the site.
• The sterile dressing is placed over the exit site of the catheter.
• Confirmation of the catheter tip position with chest radiography is required before use when internal jugular and subclavian access is obtained.[26] 

Complications

The overall rate of complications in central venous line placements is reportedly around 15%.[4] Mechanical difficulties are often operator-dependent and occur at a reported rate of 33%.[27]

Complications of CVL placements include arterial puncture, catheter malposition, pneumothorax, subcutaneous hematoma, hemothorax, and cardiac arrest (exceedingly rare). The use of real-time ultrasound guidance can significantly decrease the complication rates of this procedure.[28]

Periprocedural Complications

Pneumothorax is a severe complication of subclavian and internal jugular vein catheter placements. However, the internal jugular approach is associated with a lower rate of pneumothorax.[29] Venous air embolism, though potentially fatal, is an infrequent complication of this procedure and can be minimized by correctly positioning the patient and using diaphragms that prevent significant air embolism.[30] Arterial puncture and injury are severe complications of this procedure, and every effort should be made to avoid their occurrence. As stated above, consistent use of real-time ultrasonography can prevent this complication. If arterial trauma and cannulation occur, endovascular treatment is the best approach to minimize hematoma, airway obstruction, stroke, and false aneurysm.[31] 

If inadvertent arterial cannulation with a catheter occurs, it is better to leave the catheter in place and attempt treatment with a percutaneous closure device.[32] Ventricular arrhythmias are known complications of this procedure and are related to the placement of the guidewire and catheter tip beyond the cavoatrial junction.[33] Careful monitoring of the guidewire length as it is advanced into the vessel and determining adequate catheter length before securing it can avoid this potentially lethal complication. 

Late Complications

Catheter-related bloodstream infections (CR-BSI) are well-recognized complications of this procedure and are associated with increased morbidity and mortality for the patient.[34] The most critical risk factor for these infections is a longer duration of use, especially in dialysis patients.[35] Sequalae of CR-BSI include metastatic infections to vertebral bone or disc space, endocarditis, and endovascular infections. [34] 

Central vein stenosis is another late complication of this procedure and is most prominent in chronic hemodialysis patients who often undergo repeated cannulations of the central veins. The highest risk of this complication occurs in the left-sided internal jugular or subclavian vein cannulations.[36] Other risk factors include using hemodialysis catheters instead of flexible triple-lumen catheters and a longer duration of catheter-dwelling time.[36] In addition to central venous stenosis, catheter-related deep vein thrombosis (DVT) can also occur. Catheter-related DVT is most common in patients with underlying malignancy and using peripherally inserted multi-lumen catheters.[37] The below-mentioned table summarizes the early and late complications associated with central venous line placement.

Clinical Significance

Clinical pearls for consideration:

• A chest X-ray should be performed immediately for the internal jugular and subclavian lines to ensure proper placement and the absence of an iatrogenic pneumothorax. 
• Be sure you withdraw venous blood before dilation and cannulation of the vessel.  
• If the internal jugular CVL attempt is unsuccessful, move to the ipsilateral subclavian vein. Never attempt the opposite side without a chest X-ray or ultrasound first to avoid bilateral pneumothoraces. 
• Never force the guidewire on insertion because it may cause damage to the vessel or surrounding structures. Forcing the wire could also cause it to kink, making removal difficult and causing damage to the vessel wall. It may also lead to an inaccurate position of the catheter. 
• Always place your finger over the open hub of the needle to prevent an air embolism.
• Always confirm placement with ultrasound, looking for reverberation artifact of the needle and tenting of the vessel wall. Needles cannot be visualized on ultrasound. Wires can be visualized so the operator can also confirm at that step.
• A venous blood gas can be aspirated off a femoral line to ensure it is not arterial.

Enhancing Healthcare Team Outcomes

Central line placement is a common, often bedside, procedure. Placement under strict sterile conditions and subsequent catheter management, as well as a daily review of the need for continuing the central catheter, can help minimize complications associated with this procedure. This requires an interprofessional team of clinicians and nurses. The critical care nurse must perform daily dressing inspections, periodically change the dressing following strict aseptic technique to prevent catheter-related infections, and report back to the clinician managing the case if any concerns arise, so corrective action(s) can be taken. An aseptic technique is also required when accessing the ports of the CVL. 

Depending on the line's location, complications like pneumothorax, hematoma, bleeding, or extravasation can occur and should be monitored. Healthcare workers should generally avoid lines in the groin for more than 24 to 48 hours as they are prone to infections and make it difficult for the patient to ambulate or get out of bed. To ensure good practice and limit complications, most hospitals now have an interprofessional team of healthcare professionals in charge of central line insertion and monitoring, each checking and communicating any issues noted to the rest of the team so corrective action can occur if necessary. This universal practice has been shown to limit complications and optimize clinical outcomes for patients undergoing this procedure.[38][39] [Level 5] In the event of an infection, an infectious disease specialty pharmacist may be consulted to best target antimicrobial therapy.