[1]
From S, Płusa T. [Today's threat of ricin toxin]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 2015 Sep:39(231):162-4
[PubMed PMID: 26449579]
[2]
Pita R, Romero A. Toxins as Weapons: A Historical Review. Forensic science review. 2014 Jul:26(2):85-96
[PubMed PMID: 26227025]
[3]
Tyagi N, Tyagi M, Pachauri M, Ghosh PC. Potential therapeutic applications of plant toxin-ricin in cancer: challenges and advances. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2015 Nov:36(11):8239-46. doi: 10.1007/s13277-015-4028-4. Epub 2015 Sep 9
[PubMed PMID: 26349746]
Level 3 (low-level) evidence
[4]
Pincus SH, Bhaskaran M, Brey RN 3rd, Didier PJ, Doyle-Meyers LA, Roy CJ. Clinical and Pathological Findings Associated with Aerosol Exposure of Macaques to Ricin Toxin. Toxins. 2015 Jun 9:7(6):2121-33. doi: 10.3390/toxins7062121. Epub 2015 Jun 9
[PubMed PMID: 26067369]
[5]
Acosta W, Ayala J, Dolan MC, Cramer CL. RTB Lectin: a novel receptor-independent delivery system for lysosomal enzyme replacement therapies. Scientific reports. 2015 Sep 18:5():14144. doi: 10.1038/srep14144. Epub 2015 Sep 18
[PubMed PMID: 26382970]
[6]
O'Hara JM, Mantis NJ. Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro. Journal of immunological methods. 2013 Sep 30:395(1-2):71-8. doi: 10.1016/j.jim.2013.06.004. Epub 2013 Jun 15
[PubMed PMID: 23774033]
[7]
Yermakova A, Klokk TI, O'Hara JM, Cole R, Sandvig K, Mantis NJ. Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin's Enzymatic Subunit Interfere with Intracellular Toxin Transport. Scientific reports. 2016 Mar 7:6():22721. doi: 10.1038/srep22721. Epub 2016 Mar 7
[PubMed PMID: 26949061]
[8]
Wesche J. Retrograde transport of ricin. International journal of medical microbiology : IJMM. 2002 Feb:291(6-7):517-21
[PubMed PMID: 11890552]
[9]
Day PJ, Owens SR, Wesche J, Olsnes S, Roberts LM, Lord JM. An interaction between ricin and calreticulin that may have implications for toxin trafficking. The Journal of biological chemistry. 2001 Mar 9:276(10):7202-8
[PubMed PMID: 11113144]
[10]
Pasetto M, Barison E, Castagna M, Della Cristina P, Anselmi C, Colombatti M. Reductive activation of type 2 ribosome-inactivating proteins is promoted by transmembrane thioredoxin-related protein. The Journal of biological chemistry. 2012 Mar 2:287(10):7367-73. doi: 10.1074/jbc.M111.316828. Epub 2012 Jan 6
[PubMed PMID: 22228764]
[11]
Spooner RA, Watson PD, Marsden CJ, Smith DC, Moore KA, Cook JP, Lord JM, Roberts LM. Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum. The Biochemical journal. 2004 Oct 15:383(Pt 2):285-93
[PubMed PMID: 15225124]
[12]
Bellisola G, Fracasso G, Ippoliti R, Menestrina G, Rosén A, Soldà S, Udali S, Tomazzolli R, Tridente G, Colombatti M. Reductive activation of ricin and ricin A-chain immunotoxins by protein disulfide isomerase and thioredoxin reductase. Biochemical pharmacology. 2004 May 1:67(9):1721-31
[PubMed PMID: 15081871]
[13]
Allen SC, Moore KA, Marsden CJ, Fülöp V, Moffat KG, Lord JM, Ladds G, Roberts LM. The isolation and characterization of temperature-dependent ricin A chain molecules in Saccharomyces cerevisiae. The FEBS journal. 2007 Nov:274(21):5586-99
[PubMed PMID: 17916187]
[14]
Jolliffe NA, Di Cola A, Marsden CJ, Lord JM, Ceriotti A, Frigerio L, Roberts LM. The N-terminal ricin propeptide influences the fate of ricin A-chain in tobacco protoplasts. The Journal of biological chemistry. 2006 Aug 18:281(33):23377-85
[PubMed PMID: 16774920]
[15]
Vago R, Marsden CJ, Lord JM, Ippoliti R, Flavell DJ, Flavell SU, Ceriotti A, Fabbrini MS. Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells. The FEBS journal. 2005 Oct:272(19):4983-95
[PubMed PMID: 16176271]
[16]
Lord MJ, Jolliffe NA, Marsden CJ, Pateman CS, Smith DC, Spooner RA, Watson PD, Roberts LM. Ricin. Mechanisms of cytotoxicity. Toxicological reviews. 2003:22(1):53-64
[PubMed PMID: 14579547]
[17]
Spooner RA, Lord JM. Ricin trafficking in cells. Toxins. 2015 Jan 9:7(1):49-65. doi: 10.3390/toxins7010049. Epub 2015 Jan 9
[PubMed PMID: 25584427]
[18]
Endo Y, Mitsui K, Motizuki M, Tsurugi K. The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins. The Journal of biological chemistry. 1987 Apr 25:262(12):5908-12
[PubMed PMID: 3571242]
[19]
Endo Y, Tsurugi K. The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA. The Journal of biological chemistry. 1988 Jun 25:263(18):8735-9
[PubMed PMID: 3288622]
[20]
Deeks ED, Cook JP, Day PJ, Smith DC, Roberts LM, Lord JM. The low lysine content of ricin A chain reduces the risk of proteolytic degradation after translocation from the endoplasmic reticulum to the cytosol. Biochemistry. 2002 Mar 12:41(10):3405-13
[PubMed PMID: 11876649]
[21]
Jetzt AE, Li XP, Tumer NE, Cohick WS. Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome. Toxicology and applied pharmacology. 2016 Nov 1:310():120-128. doi: 10.1016/j.taap.2016.09.004. Epub 2016 Sep 15
[PubMed PMID: 27639428]
[22]
Meneguelli de Souza LC, Carvalho LP, Araújo JS, Melo EJT, Machado OLT. Cell toxicity by ricin and elucidation of mechanism of Ricin inactivation. International journal of biological macromolecules. 2018 Jul 1:113():821-828. doi: 10.1016/j.ijbiomac.2018.03.024. Epub 2018 Mar 6
[PubMed PMID: 29522821]
[23]
Liu WY. Research on ribosome-inactivating proteins from angiospermae to gymnospermae and cryptogamia. American journal of translational research. 2017:9(12):5719-5742
[PubMed PMID: 29312524]
[24]
Simon S, Worbs S, Avondet MA, Tracz DM, Dano J, Schmidt L, Volland H, Dorner BG, Corbett CR. Recommended Immunological Assays to Screen for Ricin-Containing Samples. Toxins. 2015 Nov 26:7(12):4967-86. doi: 10.3390/toxins7124858. Epub 2015 Nov 26
[PubMed PMID: 26703725]
[25]
Worbs S, Skiba M, Söderström M, Rapinoja ML, Zeleny R, Russmann H, Schimmel H, Vanninen P, Fredriksson SÅ, Dorner BG. Characterization of Ricin and R. communis Agglutinin Reference Materials. Toxins. 2015 Nov 26:7(12):4906-34. doi: 10.3390/toxins7124856. Epub 2015 Nov 26
[PubMed PMID: 26703723]
[26]
Diakite ML, Rollin J, Jary D, Berthier J, Mourton-Gilles C, Sauvaire D, Philippe C, Delapierre G, Gidrol X. Point-of-care diagnostics for ricin exposure. Lab on a chip. 2015 May 21:15(10):2308-17. doi: 10.1039/c5lc00178a. Epub
[PubMed PMID: 25892365]
[27]
Bozza WP, Tolleson WH, Rivera Rosado LA, Zhang B. Ricin detection: tracking active toxin. Biotechnology advances. 2015 Jan-Feb:33(1):117-123. doi: 10.1016/j.biotechadv.2014.11.012. Epub 2014 Dec 4
[PubMed PMID: 25481398]
Level 3 (low-level) evidence
[28]
Slotved HC, Sparding N, Tanassi JT, Steenhard NR, Heegaard NH. Evaluating 6 ricin field detection assays. Biosecurity and bioterrorism : biodefense strategy, practice, and science. 2014 Jul-Aug:12(4):186-9. doi: 10.1089/bsp.2014.0015. Epub 2014 Jun 30
[PubMed PMID: 24978020]
[29]
Tevell Åberg A, Björnstad K, Hedeland M. Mass spectrometric detection of protein-based toxins. Biosecurity and bioterrorism : biodefense strategy, practice, and science. 2013 Sep:11 Suppl 1():S215-26. doi: 10.1089/bsp.2012.0072. Epub
[PubMed PMID: 23971809]
[30]
Becker B, Schnöder T, Schmitt MJ. Yeast Reporter Assay to Identify Cellular Components of Ricin Toxin A Chain Trafficking. Toxins. 2016 Dec 6:8(12):
[PubMed PMID: 27929418]
[31]
Ricin: current understanding and prospects for an antiricin vaccine., Marsden CJ,Smith DC,Roberts LM,Lord JM,, Expert review of vaccines, 2005 Apr
[PubMed PMID: 15889996]
Level 3 (low-level) evidence
[32]
Marsden CJ, Knight S, Smith DC, Day PJ, Roberts LM, Phillips GJ, Lord JM. Insertional mutagenesis of ricin A chain: a novel route to an anti-ricin vaccine. Vaccine. 2004 Jul 29:22(21-22):2800-5
[PubMed PMID: 15246614]
[33]
Coopman V, De Leeuw M, Cordonnier J, Jacobs W. Suicidal death after injection of a castor bean extract (Ricinus communis L.). Forensic science international. 2009 Aug 10:189(1-3):e13-20. doi: 10.1016/j.forsciint.2009.04.019. Epub 2009 May 23
[PubMed PMID: 19477090]
[34]
Schep LJ, Temple WA, Butt GA, Beasley MD. Ricin as a weapon of mass terror--separating fact from fiction. Environment international. 2009 Nov:35(8):1267-71. doi: 10.1016/j.envint.2009.08.004. Epub 2009 Sep 19
[PubMed PMID: 19767104]
[35]
Centers for Disease Control and Prevention (CDC). Investigation of a ricin-containing envelope at a postal facility--South Carolina, 2003. MMWR. Morbidity and mortality weekly report. 2003 Nov 21:52(46):1129-31
[PubMed PMID: 14627953]
[36]
Gaillard Y, Regenstreif P, Fanton L. Modern toxic antipersonnel projectiles. The American journal of forensic medicine and pathology. 2014 Dec:35(4):258-64. doi: 10.1097/PAF.0b013e318288abe8. Epub
[PubMed PMID: 25354227]