Lens Induced Glaucoma

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Continuing Education Activity

Lens-induced glaucoma (LIG) is a common entity presenting to the outpatient department as an acute painful diminution of vision with red-eye. The presentation varies from children with ectopia lentis to elderly cases with mature cataracts. This activity describes the evaluation and management of LIG and reviews the role of the interprofessional team in adequately evaluating and managing patients with this condition.

Objectives:

  • Describe the various types of lens-induced glaucoma (LIG).
  • Review the differential diagnosis for the common clinical presentations of lens-induced glaucoma (LIG).
  • Identify the characteristic signs that can help a clinician arrive at an early diagnosis of lens-induced glaucoma (LIG).
  • SUmmarize how to manage lens-induced glaucoma (LIG) cases and provide satisfactory visual rehabilitation.

Introduction

Lens-induced glaucoma (LIG) was originally described by Gifford in 1900 as glaucoma associated with hyper-mature senile cataracts (HMSC). Von Ruess independently described LIG as glaucoma with spontaneous absorption of lens matter through an intact capsule.[1] The literature has a multitude of similar entities described over the decades. LIG is secondary glaucoma mimicking acute angle-closure glaucoma (ACG), with normal intraocular pressure (IOP) and open-angles in the contralateral eye, and prompt relief of symptoms following cataract extraction. 

Based on the pathogenesis, LIG is further classified as:

1. Lens protein-related: Leakage of lens protein across an intact or a breached lens capsule. This form includes:

  • Phacolytic glaucoma (PLG)
  • Lens-particle induced glaucoma (LPIG)
  • Phacoanaphylactic glaucoma (PAG)

2. Aqueous flow obstruction: Anatomical obstruction of aqueous flow from the posterior to the anterior chamber. This type includes:

  • Phacomorphic glaucoma (PMG)
  • Pupillary block glaucoma (PBG)

Some causes like pseudo-exfoliation glaucoma and ciliary block glaucoma are debatable entities under LIG.

Etiology

Congenital Ectopia Lentis (EL) can result in aqueous flow obstruction. Various forms include the following:

  • Marfan syndrome - Bilateral supero-temporal subluxation of the lens with occasional acute dislocation and PBG in early childhood[2]
  • Homocystinuria - Bilateral inferonasal lenticular subluxation with acute anterior chamber dislocation and PBG are common.[3]
  • Weill-Marchesani syndrome - Microspherophakia, ciliary body hypoplasia, PBG, and inverse glaucoma are associated.
  • Others: Ehler-Danlos syndrome, sulfite oxidase deficiency, hyperlysinemia, aniridia, Alport syndrome, Axenfeld-Rieger syndrome, and Peter anomaly type 3

Acquired includes the following:

  • Trauma - Can cause anterior dislocation of lens and PBG. Traumatic rupture of the lens causes immediate LPIG or a delayed PAG.
  • Post-surgery - Retained loose lenticular matter can precipitate an acute attack of LPIG or a chronic PAG.
  • Intumescent cataract - Can cause PMG.
  • HMSC - Micro-ruptures in the lens capsule cause PLG.

Epidemiology

The epidemiology varies across developed and developing countries. The congenital varieties form a greater proportion in the developed countries with easy access to healthcare. The estimated prevalence of congenital ectopia lentis is 6.4/ 100,000 population.[4] 

In developing and countries with more limited resources, acquired LIG from advanced senile cataracts are the more prevalent subtype. The incidence of LIG is up to 2.4% at the time of the presentation of senile cataracts with a female preponderance.[1]

Pathophysiology

PLG: Flocks coined the term - Phacolytic glaucoma.[5] Epstein described the role of high-molecular-weight lens protein (HMW-LP) in the pathogenesis of PLG.[6][7] Microdefects in the cataractous lens capsule lead to a progressive leak of the soluble lens proteins into the aqueous humor. The macrophages phagocytose these proteins and block the trabecular meshwork (TM), causing acute open-angle glaucoma[6]. The recent theory states HMW-LP directly obstructs the TM to impede the aqueous outflow and precipitates PLG. The increase in the content of HMW-LP in the human lens with increasing age supports this theory.

LPIG: Lens-particle-induced glaucoma was previously mislabeled as 'phacotoxic uveitis.' There is a release of lens particles after extra-capsular cataract extraction (ECCE) or a traumatic rupture of the lens capsule. The lens particles deposit directly into the TM, obstructing the aqueous outflow and leading to open-angle glaucoma. There is minimal-to-nil inflammation in LPIG.

PAG: Verhoeff and Lemoine described this entity as 'endophthalmitis phacoanaphylactica.'[8] The release of lens particles is similar to LPIG. There is a sensitization period of one to 14 days between the release and the onset of glaucoma.[9] The inflammation of TM is mediated by type III hypersensitivity - Arthus type reaction mediated by IgG and the complement system.[10]

PBG: The mechanism of classic pupillary block glaucoma is obstruction of aqueous flow in the mid-dilated pupil. An anteriorly positioned lens may worsen this condition. The presence of ectopia lentis with an anteriorly dislocated lens also blocks the aqueous flow similarly. 

PMG: Phacomorphic glaucoma is precipitated by a sudden increase in the volume of the cataractous lens. The presence of an intumescent cataractous lens leads to pupillary block. Acute angle-closure with a shallow anterior chamber, with an open angle in the contralateral eye, suggests PMG.

Histopathology

For the acute inflammatory entities - PLG and PAG, a cytopathology examination of the aqueous humor suggest two distinct inflammatory patterns. PLG shows a chronic inflammatory reaction and macrophages with engulfed lens proteins.[11] PAG has a granulomatous zone of reaction with polymorphonuclear leukocytes, giant cells, epithelioid cells, and a cuff of lymphocytes and plasma cells.[12] 

History and Physical

The common ocular complaints in patients of LIG are:

  • Redness of the eye- sudden onset
  • Unilateral eye pain - sudden onset, may be accompanied by headache, nausea, and vomiting
  • Diminution of vision - gradually progressive in cases of cataracts
  • Colored halos, photophobia, and epiphora 

A detailed history regarding the onset, duration, and progression of the presenting symptoms is essential. The clinician must note any history of similar episodes or ocular surgery.

Any clinical history suggestive of a contraindication to systemic steroid use like osteoporosis, peptic ulcer disease, psychiatric illness, or tuberculosis should be elicited.

Evaluation

  • Measure the best-corrected visual acuity and any improvement with the pinhole. For EL cases, cycloplegic refraction may be performed. 
  • Facial symmetry and head posture
  • Binocular alignment: The eyes with advanced cataracts and poor vision can have sensory exotropia. The presence of a comitant squint since childhood suggests poor visual prognosis in unilateral EL cases. 

Clinical Examination

  • Ocular adnexa: Possible swelling and redness of the eyelids
  • Conjunctiva: Congestion and chemosis 
  • Sclera: Dilated episcleral vessels
  • Cornea: The raised IOP causes stromal edema, sub-epithelial bullae, and Descemet membrane folds. PAG and PLG cases show fresh keratitic precipitates on the posterior surface of the cornea. Lens proteins deposit on the posterior surface of the cornea in LPIG. 
  • Anterior chamber (AC): AC depth decreases in PMG and PBG. The aqueous humor shows lens particles in LPIG. PAG and PLG show AC reaction due to the presence of inflammatory cells and AC flare due to leakage of inflammatory proteins. PLG shows hyper-refringent particles composed of calcium oxalate or cholesterol crystals.[13]
  • Iris: PBG and PMG show anterior bowing of the iris. Prolonged inflammation in PAG or PLG may present with posterior synechiae and peripheral anterior synechiae (PAS). Inflammatory pseudo-hypopyon is rarely seen in PAG.
  • Pupil: The cases with a prolonged rise of IOP have a vertically oval pupil due to ischemia of the sphincter pupillae muscle. PBG has a classical mid-dilated pupil. Chronic PAG and PLG cases can exhibit a festooned pupil. A brisk consensual light reflex in the contralateral eye suggests an excellent visual prognosis. 
  • Lens: PMG shows an intumescent mature senile cataract (MSC). In LPIG, a rupture of the lens capsule with a cataractous lens may be visible. PLG shows MSC or HMSC. PAG can have a ruptured lens capsule or an anterior capsulorhexis with residual lens matter. PBG due to EL demonstrates an anteriorly positioned lens. 
  • Posterior segment: Cases of total cataracts obstruct the view of the fundus. 

Investigations

  • Applanation tonometry (AT): Goldmann AT is the gold standard for IOP measurement.
  • Gonioscopy: Angle examination is mandatory in cases with a clear cornea. PMG shows a closed or an occludable angle in the involved eye, with a narrow or open-angle in the contralateral eye depending on the stage of cataract in that eye. An occludable angle in the contralateral eye suggests a PBG mechanism. LPIG shows open-angle with lens particle deposition. Chronic PLG and PAG may have synechial angle closure with PAS formation. EL often has a 'volcano configuration' of the iris, with the pupil forming the central crater.
  • Ocular ultrasonography: It provides an image of the posterior segment in cases with no view of the fundus. 
  • Anterior segment ocular coherence tomography (AS-OCT): A reduced AC depth and angle opening distance, increased lens vault, and the axial length correlate with the occurrence of PMG.[14]
  • Aqueous humor cytology is rarely required to help elucidate the pathology in uveitis of unknown etiology. It helps differentiate PAG or PLG from infective conditions.     

Treatment / Management

The primary goal is adequate intraocular pressure (IOP) control. The definitive management is the removal of inciting lenticular matter. 

IOP Management

  • Laser peripheral iridotomy (LPI): For PBG and PMG, it may relieve any component of the pupillary block but may be insufficient to control the IOP.
  • Topical antiglaucoma medication (AGM): The first-line management includes beta-blockers, alpha-agonists, and carbonic anhydrase inhibitors. Prostaglandin analogs and miotics can be used but may increase intraocular inflammation. 
  • Systemic IOP lowering agents: Hyperosmotic agents (i.e., mannitol) and carbonic anhydrase inhibitors (acetazolamide) augment the effect of topical agents. Vigilant monitoring of kidney function and serum electrolytes is essential.
  • Corticosteroids: Topical and systemic corticosteroids lower the inflammation in PAG and PLG before the definitive cataract surgery.
  • Pars plana vitrectomy is sometimes required before cataract surgery if there is inadequate anterior chamber space to safely perform cataract surgery in cases of hyper mature or intumescent cataracts.

Lens Extraction - ideally performed after adequate IOP control

  • Cataract extraction. As per the surgeons' experience, conventional ECCE, small incision cataract surgery (SICS), or phacoemulsification techniques are employed to remove the lens.
  • The traumatic lens rupture and residual lenticular matter after cataract surgery do well with a total lens aspiration in cases of LPIG and PAG. 
  • For gross lens subluxation or anterior dislocation in EL, various techniques may be employed depending on the degree of subluxation.  Phacoemulsification combined with sutured capsular segments may be preferred for mild to moderate subluxation.  For severe or posterior subluxation, vitrectomy combined with pars plana lensectomy or intracapsular cataract extraction may be required.
  • For patients denying the perception of light and thus unlikely to improve vision, cataract surgery can still be performed to control inflammation and pain.

Visual Rehabilitation

  • The cases with an intact posterior capsule and adequate bag stability can have primary implantation of a posterior chamber intraocular lens (IOL).  
  • For subluxated cataracts, devices like capsule tension rings or Cionne rings stabilize the bag and facilitate implantation of a posterior chamber IOL.  
  • For ICCE and lensectomy cases, a primary or secondary scleral-fixated IOL or an anterior chamber IOL have variable success rates. In the post-surgery period, topical AGMs control the IOP.
  • Gonio-synechialysis, in conjunction with cataract surgery, is a management option for PAS formation in chronic LIG.
  • PLG - An immediate lens extraction alone results in a well-controlled IOP if the preceding history is less than a week. For a history of more than two weeks, combined cataract surgery with trabeculectomy shows a better IOP control.[15]
  • PMG - Cataract surgery alone is useful for IOP control and visual rehabilitation for patients presenting within four weeks. A combined surgery - lens extraction and trabeculectomy, is planned for chronic PMG.[16]
  • For painful blind eyes, cataract surgery or cyclodiode laser treatment may be considered to lower the IOP.

Differential Diagnosis

Acute angle-closure glaucoma (ACG): This entity can be confused with PMG or PLG. Eliciting a positive family history for glaucoma and history of past similar episodes helps differentiate them. Gonioscopy of the contralateral eye helps distinguish the exact mechanism.

Ciliary block glaucoma (CBG): Malignant glaucoma or aqueous misdirection syndrome occurs due to anterior rotation of the ciliary body and accumulation of aqueous behind the anterior hyaloid. PBG is a commonly confused entity. Laser peripheral iridotomy (LPI) is diagnostic as it provides relief of the PBG attack, while no lowering of the IOP occurs in CBG. 

Supra-choroidal hemorrhage: It can mimic PBG with a flat AC and raised IOP. A detailed fundus evaluation shows a classic dark red elevation or, in cases of poor view of the fundus, B-scan ultrasound can be performed to aid in the diagnosis. 

Choroidal effusion: This condition classically presents with a low IOP. If the effusion involves a ciliary body and secondary cyclodialysis, it can present with raised IOP and a flat AC, mimicking PBG.

Post-traumatic endophthalmitis: The presence of a hypopyon, elevated IOP, corneal edema, or AC flare with a ruptured lens can mimic or coexist with PAG. A microbiological evaluation of the anterior chamber or vitreous tap helps exclude endophthalmitis.

Prognosis

An early presentation and prompt management may allow a good visual prognosis. Early lens extraction under adequate IOP control is the cornerstone of management. Delayed and chronic presentations have a poorer prognosis. The development of PAS is a poor prognostic indicator and requires regular IOP monitoring with medical and/or surgical management.

The combined cataract extraction with trabeculectomy has good IOP control in the immediate post-surgical period. However, the trabeculectomy failure rates of combined surgery are high in the long term.

Complications

  • Persistent inflammation
  • Pigment and/or proteinaceous deposits on the IOL 
  • PAS formation - synechial ACG
  • Persistent elevation of IOP with failure of glaucoma filtration surgery
  • Poor gain of vision
  • Glaucomatous optic atrophy
  • Endophthalmitis
  • Expulsive choroidal hemorrhage
  • Loss of vision
  • Painful atrophic bulbi
  • Phthisis bulbi

Postoperative and Rehabilitation Care

Stringent IOP monitoring and tapering of pressure-lowering medications are the cornerstones of glaucoma management. Regular fundus evaluation with perimetry is recommended. Visual rehabilitation includes refraction at four to six weeks with appropriate distance and near prescription.

Deterrence and Patient Education

The children suffering from syndromes linked with EL should be screened early for potential lenticular subluxation. Regular IOP monitoring and refraction are needed for these patients. 

The elderly population must have easy access to health facilities. They should be screened regularly for the development and progression of senile cataracts, with treatment being offered to them before the development of MSC and corresponding LIG.

Enhancing Healthcare Team Outcomes

Cases of an acute red eye with painful diminution of vision must be thoroughly investigated.  These cases may initially present to general practitioners or optometrists. Cases of LIG should be referred to an ophthalmologist as surgery is usually required for definitive management. An aggressive IOP control strategy is needed before the lenticular extraction surgery and often requires topical and systemic medications. Post-surgery follow-up and visual rehabilitation are necessary, as intraocular inflammation and IOP elevation may require ongoing monitoring and management.



(Click Image to Enlarge)
Phacomorphic Glaucoma
Phacomorphic Glaucoma
Contributed by Shalin Shah, MBBS, MRCS

(Click Image to Enlarge)
Phaco-anaphylactic glaucoma
Phaco-anaphylactic glaucoma
Contributed by Shalin Shah, MBBS, MRCS

(Click Image to Enlarge)
Phacolytic Glaucoma
Phacolytic Glaucoma
Contibuted by Shalin Shah, MBBS, MRCSEd

(Click Image to Enlarge)
Lens particle glaucoma
Lens particle glaucoma
Contributed by Shalin Shah, MBBS, MRCSEd
Article Details

Article Author

Shalin S. Shah

Article Editor:

Jay J. Meyer

Updated:

9/26/2022 5:59:42 PM

PubMed Link:

Lens Induced Glaucoma

References

[1]

Kothari R,Tathe S,Gogri P,Bhandari A, Lens-Induced Glaucoma: The Need to Spread Awareness about Early Management of Cataract among Rural Population. ISRN ophthalmology. 2013;     [PubMed PMID: 24555131]

[2]

Challa P,Hauser MA,Luna CC,Freedman SF,Pericak-Vance M,Yang J,McDonald MT,Allingham RR, Juvenile bilateral lens dislocation and glaucoma associated with a novel mutation in the fibrillin 1 gene. Molecular vision. 2006 Aug 28;     [PubMed PMID: 16971892]

[3]

Harrison DA,Mullaney PB,Mesfer SA,Awad AH,Dhindsa H, Management of ophthalmic complications of homocystinuria. Ophthalmology. 1998 Oct;     [PubMed PMID: 9787359]

[4]

Fuchs J,Rosenberg T, Congenital ectopia lentis. A Danish national survey. Acta ophthalmologica Scandinavica. 1998 Feb;     [PubMed PMID: 9541430]

[5]

FLOCKS M,LITTWIN CS,ZIMMERMAN LE, Phacolytic glaucoma; a clinicopathologic study of one hundred thirty-eight cases of glaucoma associated with hypermature cataract. A.M.A. archives of ophthalmology. 1955 Jul;     [PubMed PMID: 14375459]

[6]

Epstein DL,Jedziniak JA,Grant WM, Obstruction of aqueous outflow by lens particles and by heavy-molecular-weight soluble lens proteins. Investigative ophthalmology     [PubMed PMID: 627464]

[7]

Epstein DL,Jedziniak JA,Grant WM, Identification of heavy-molecular-weight soluble protein in aqueous humor in human phacolytic glaucoma. Investigative ophthalmology     [PubMed PMID: 640786]

[8]

Ellant JP,Obstbaum SA, Lens-induced glaucoma. Documenta ophthalmologica. Advances in ophthalmology. 1992;     [PubMed PMID: 1483374]

[9]

Perlman EM,Albert DM, Clinically unsuspected phacoanaphylaxis after ocular trauma. Archives of ophthalmology (Chicago, Ill. : 1960). 1977 Feb;     [PubMed PMID: 836209]

[10]

Thach AB,Marak GE Jr,McLean IW,Green WR, Phacoanaphylactic endophthalmitis: a clinicopathologic review. International ophthalmology. 1991 Jul     [PubMed PMID: 1917323]

[11]

Rosenbaum JT,Samples JR,Seymour B,Langlois L,David L, Chemotactic activity of lens proteins and the pathogenesis of phacolytic glaucoma. Archives of ophthalmology (Chicago, Ill. : 1960). 1987 Nov;     [PubMed PMID: 3675292]

[12]

Mavrakanas N,Axmann S,Issum CV,Schutz JS,Shaarawy T, Phacolytic glaucoma: are there 2 forms? Journal of glaucoma. 2012 Apr-May;     [PubMed PMID: 21423037]

[13]

Peracha-Riyaz MH,Peracha ZH,Spaulding J,Baciu P,Ahmed S,Imami NR,Darnley-Fisch D,Desai U, First Described Case of Anterior and Posterior Segment Crystals in Phacolytic Glaucoma. Journal of glaucoma. 2017 May;     [PubMed PMID: 28234682]

[14]

Moghimi S,Ramezani F,He M,Coleman AL,Lin SC, Comparison of Anterior Segment-Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Acute Angle Closure Eyes. Investigative ophthalmology     [PubMed PMID: 26624492]

[15]

Braganza A,Thomas R,George T,Mermoud A, Management of phacolytic glaucoma: experience of 135 cases. Indian journal of ophthalmology. 1998 Sep;     [PubMed PMID: 10085625]

[16]

Senthil S,Chinta S,Rao HL,Choudhari NS,Pathak-Ray V,Mandal AK,Garudadri CS, Comparison of Cataract Surgery Alone Versus Cataract Surgery Combined With Trabeculectomy in the Management of Phacomorphic Glaucoma. Journal of glaucoma. 2016 Mar;     [PubMed PMID: 25642811]